Antiphospholipid Syndrome
Antiphospholipid Syndrome (APS) important in vascular medicine as well as obstetrics. In obstetrics, it is important because it can cause fetal loss, intrauterine growth retardation and severe preeclampsia. In vascular medicine it is important because it can cause thrombotic events which could be arterial, venous or microvascular [1]. It can also be accompanied by moderate thrombocytopenia [2]. Thrombotic events involving multiple organs may be termed catastrophic Antiphospholipid Syndrome [3].
APS is an autoimmune disease with antibodies directed against beta2 glycoprotein I. This leads to suppression of tissue factor p...
Source: Cardiophile MD - May 27, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology anti beta2 glycoprotein I antibodies anti cardiolipin antibodies lupus anticoagulant Source Type: blogs
Airway hemorrhage in Eisenmenger syndrome – Cardiology MCQ – Answer
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Cardiology MCQs from Cardiophile MD – Volume 3: Interactive Kindle Edition
Cardiology MCQs from Cardiophile MD – Volume 3 Paperback
All of the following are true about airway hemorrhages in Eisenmenger syndrome except:
Correct answer: c) More likely while descending a mountain
In Eisenmenger syndrome airway hemorrhages have to be thought of specially when moving from lower to a higher altitude as during air travel or while ascending a mountain. Hemoptysis has been reported as a cause of death in Eisenmenger syndrome in 11-29% [1].
Defects in hemostatic mechanism due to abnormal platelet function, throm...
Source: Cardiophile MD - May 15, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Airway hemorrhage in Eisenmenger syndrome – Cardiology MCQ
All of the following are true about airway hemorrhages in Eisenmenger syndrome except:
a) Can be potentially life threatening
b) More likely to occur during air travel
c) More likely while descending a mountain
d) Thrombocytopenia and abnormal platelet function may be contributory
Post your answer as a comment below. Correct answer will be published on: May 15, 2018 @ 11:37
The post Airway hemorrhage in Eisenmenger syndrome – Cardiology MCQ appeared first on Cardiophile MD. (Source: Cardiophile MD)
Source: Cardiophile MD - May 13, 2018 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Further Investigation of the Role of Osteopontin in Hematopoietic Stem Cell Aging
The Hematopoietic stem cell population resident in bone marrow is responsible for generating blood cells and immune cells. Like all stem cell populations, their activity alters and declines with aging. This is one of the causes of the progressive disarray of the immune system in older individuals. If we want to rejuvenate the immune system, then restoring the youthful activity of hematopoietic stem cells is one of the items on the to-do list, alongside regrowth of the thymus, and clearing out the accumulation of exhausted, senescent, and misconfigured immune cells.
The protein osteopontin appears to have a sizable r...
Source: Fight Aging! - February 16, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
LITFL Review 313
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Welcome to the 313rd LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM.
The Most Fair Dinkum Ripper Beauts of the Week
Hard to be skeptical about the Skeptic’s Guide to Emergency Medicine (SGEM) this year! Chr...
Source: Life in the Fast Lane - December 31, 2017 Category: Emergency Medicine Authors: Marjorie Lazoff, MD Tags: Education LITFL review Source Type: blogs
Cardiology MCQ Test 3
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Source: Cardiophile MD - October 20, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Cardiology MCQ Test 2
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Source: Cardiophile MD - October 19, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Severe Fever and Thrombocytopenia Syndrome
Incidence data for Severe Fever and Thrombocytopenia Syndrome are displayed in the following chart [1] In contrast with Japan, The Republic of Korea has experienced a dramatic increase in rates since the disease was first reported.
Reference:
https://www.youtube.com/watch?v=q1vlA_wi2xo
The post Severe Fever and Thrombocytopenia Syndrome appeared first on GIDEON - Global Infectious Diseases and Epidemiology Online Network. (Source: GIDEON blog)
Source: GIDEON blog - September 15, 2017 Category: Databases & Libraries Authors: Dr. Stephen Berger Tags: Epidemiology Graphs Source Type: blogs
Notes to myself – 2
Pentobarb coma – BIS should be 10-20 and SR (suppression ratio) should be 70-80
Consider lev albuterol
Should give vaccines after coiling of spleen or before if possible
No calcium channel blockers post MI definitely and post op in general
Toradol inhibits spine healing
Don’t do endoscopes with patients in supine position
don’t ambulate patients with known dvt’s. wait 2-3 days until clots get stuck.
dvt’s even with filter get heparin as much as possible for post phlebitic syndrome and to retard new clot formation
diffuse alveolar hemorrhage – secondary to chemo, goodpasture’s, wege...
Source: Inside Surgery - December 31, 2016 Category: Surgery Authors: Editor Tags: General Source Type: blogs
Piperlongumine as a Senolytic Drug Candidate with Fewer Side-Effects
Today's open access research paper outlines the discovery of yet another new candidate drug for the selective destruction of senescent cells. This is an increasingly popular research topic nowadays. Senescent cells perform a variety of functions, but on the whole they are bad news. Cells become senescent in response to stresses or reaching the Hayflick limit to replication. They cease further division and start to generate a potent mix of signals, the senescence-associated secretory phenotype or SASP, that can provoke inflammation, disarray the surrounding extracellular matrix structures, and change behavior of nearby cell...
Source: Fight Aging! - December 21, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Thrombocytopenia as a prognostic marker in septic shock
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - September 12, 2016 Category: Internal Medicine Tags: critical care hematology hospital medicine Source Type: blogs
The Dangerous Expansion of Adult Vaccinations
Conclusion
The vaccination comprises a misguided and unsafe national health care program which claims to prevent disease. Many significant health injuries are associated with vaccinating adults. Government resources are being spent researching and developing new and different vaccinations. Subjecting adults to more vaccinations is likely to cause more health injury and illness.
References:
http://www.vaccinationcouncil.org/2012/07/05/herd-immunity…
http://www.cdc.gov/chronicdisease/overview/
http://www.vaccinationcouncil.org/2011/02/18/60-lab-studies…
http://www.cdc.gov/vaccines/schedules/hcp/adult.html
http:...
Source: vactruth.com - September 10, 2016 Category: Allergy & Immunology Authors: Michelle Goldstein Tags: Logical Michelle Goldstein Recent Articles Top Stories adult vaccination adult vaccines new vaccines shingles vaccine truth about vaccines Source Type: blogs
Advantages of low molecular weight heparin – Cardiology MCQ
Advantages of low molecular weight heparin (LMWH) over unfractionated heparin (UFH) includes all of the following except:
a) Nearly complete absorption after subcutaneous administration
b) More predictable dose-effect relationship
c) More platelet activation
d) Lower risk of heparin induced thrombocytopenia syndrome
Correct answer: c) More platelet activation
Low molecular weight heparin produces less of platelet activation than UFH. Though the risk of heparin induced thrombocytopenia syndrome (HIT) is lower with LMWH, it cannot be substituted for UFH once HIT has occurred as the HIT antibodies crossreact with LMWH. If ant...
Source: Cardiophile MD - August 25, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
Leucovorin to the Rescue
A 78-year-old man was advised to go to the emergency department by his rheumatologist after reporting symptoms of nausea, severe fatigue, and feeling "off" for two days. The patient had recently been prescribed methotrexate for his polymyalgia rheumatica, and was instructed to take 5 mg once a week, but he misunderstood and took 5 mg daily for six days.The patient's heart rate was 80 beats per minute, his blood pressure was 155/75 mm Hg, his pulse ox was 98% on room air, and his temperature was 98°F. His initial labs included a CBC with no abnormalities, but his creatinine was 2.5 mg/dL with a GFR of 25. Baselin...
Source: The Tox Cave - August 1, 2016 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
