Thyme Oil-Containing Fluconazole-Loaded Transferosomal Bigel for Transdermal Delivery
The objective of the present research was to develop fluconazole-loaded transferosomal bigels for transdermal delivery by employing statistical optimization (23 factorial design-based). Thin-film hydration was employed to prepare fluconazole-loaded transferomal suspensions, which were then incorporated into bigel system. A 23 factorial design was employed where ratios of lipids to edge activators, lipids (soya lecithin to cholesterol), and edge activators (sodium deoxycholate to Tween 80) were factors. Ex vivo permeation flux (Jss) of transferosomal bigels across porcine skin was analyzed as response. The optimal setting f...
Source: AAPS PharmSciTech - November 22, 2023 Category: Drugs & Pharmacology Authors: Biswarup Das Amit Kumar Nayak Subrata Mallick Source Type: research
Thyme Oil-Containing Fluconazole-Loaded Transferosomal Bigel for Transdermal Delivery
The objective of the present research was to develop fluconazole-loaded transferosomal bigels for transdermal delivery by employing statistical optimization (23 factorial design-based). Thin-film hydration was employed to prepare fluconazole-loaded transferomal suspensions, which were then incorporated into bigel system. A 23 factorial design was employed where ratios of lipids to edge activators, lipids (soya lecithin to cholesterol), and edge activators (sodium deoxycholate to Tween 80) were factors. Ex vivo permeation flux (Jss) of transferosomal bigels across porcine skin was analyzed as response. The optimal setting f...
Source: AAPS PharmSciTech - November 22, 2023 Category: Drugs & Pharmacology Authors: Biswarup Das Amit Kumar Nayak Subrata Mallick Source Type: research
