High-Dose VX-548 Reduces Acute Pain Over 48 Hours
FRIDAY, Aug. 4, 2023 -- High-dose VX-548, an oral, highly selective inhibitor of the Nav1.8 voltage-gated sodium channel, reduces acute pain over 48 hours after abdominoplasty and bunionectomy, according to a study published in the Aug. 3 issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 4, 2023 Category: Pharmaceuticals Source Type: news
How drinking more than 1.4 LITRES of water within an hour could be a lethal mistake - after death of 35-year-old mother
Drinking more than 1.4 litres an hour can cause the body's sodium levels to drop and cells to swell, including those in the brain. That's what happened to a mother-of-two in Indiana. (Source: the Mail online | Health)
Source: the Mail online | Health - August 4, 2023 Category: Consumer Health News Source Type: news
Do GLP-1 Agonists Worsen Diabetic Retinopathy? Do GLP-1 Agonists Worsen Diabetic Retinopathy?
Patients taking glucagon-like peptide-1 agonists were more likely to progress from nonproliferative diabetic retinopathy to proliferative disease or diabetic macular edema than those who took sodium-glucose cotransporter-2 inhibitors.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 3, 2023 Category: Consumer Health News Tags: Ophthalmology News Source Type: news
Novel Drug Reduces Acute Pain After Common Surgeries
(MedPage Today) -- A novel, investigational NaV1.8 sodium channel blocker known as VX-548 reduced acute pain after abdominoplasty or bunionectomy at the highest dose, but not at lower doses, two phase II trials showed.
The primary endpoint was... (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - August 2, 2023 Category: Surgery Source Type: news
Pandemic Blamed for Failed Trial of Inhaled Antibiotic Pandemic Blamed for Failed Trial of Inhaled Antibiotic
Inhaled colistimethate sodium showed a large benefit in one trial but produced almost no effect in the other, a result attributed to the COVID pandemic.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 31, 2023 Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news
AI helps crack salt water ’s curious electrical properties
Water is a near-universal solvent, able to dissolve substances ranging from limestone to the sugar in your coffee. That chemical superpower originates, oddly enough, in water’s electrical properties. It can oppose and almost entirely cancel electric fields—including attractions among dissolved ions that might otherwise pull them together. Curiously, dissolving salt in water weakens that electrical response. Now, a team of physicists has figured out exactly why this happens, using state-of-the-art computer simulations bolstered by artificial intelligence (AI).
“This is a fundamental property of water and one can...
Source: ScienceNOW - July 28, 2023 Category: Science Source Type: news
SGLT2i Use Linked to Reduced Risk for Flare in Adults With Gout, T2D
MONDAY, July 24, 2023 -- For patients with gout and type 2 diabetes, sodium-glucose cotransporter-2 inhibitors (SGLT2is) are associated with a reduced risk for recurrent gout flares and gout-primary emergency department visits and hospitalizations,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 24, 2023 Category: Pharmaceuticals Source Type: news
Internet-purchased sodium azide used in a fatal suicide attempt: a case report and review of the literature - van der Heijden LT, van den Hondel KE, Olyslager EJH, de Jong LAA, Reijnders UJL, Franssen EJF.
There has been a significant increase in sodium azide intoxications since the 1980s. Intoxications caused by sodium azide are becoming increasingly prevalent in the Netherlands as a result of its promotion for the purpose of self-euthanasia. The mechanism ... (Source: SafetyLit)
Source: SafetyLit - July 19, 2023 Category: International Medicine & Public Health Tags: Media, Marketing, and Internet Issues Source Type: news
How to Tell The Difference Between Heat Stress, Exhaustion, and Stroke
The terminology around heat injuries and illness is often confusing. As extreme heat warnings sweep the U.S., here is what you need to know about heat stress, heat exhaustion, and heat stroke.
A 90°F-day might be perfect for the beach. But once you start working your body, whether it’s mowing the lawn, going for a hike, or sprinting to catch the bus, your metabolism ramps up, burning fuel and raising your body’s core temperature. Your heart compensates by pumping blood away from your overheated organs to your skin, where dilating blood vessels can dissipate the heat with the help of evaporating sweat. If yo...
Source: TIME: Health - July 18, 2023 Category: Consumer Health News Authors: Aryn Baker Tags: Uncategorized Climate Is Everything Explainer extreme weather healthscienceclimate Source Type: news
Suicidal sodium nitrite intoxication: a case report focusing on the postmortem findings and toxicological analyses-review of the literature - Andelhofs D, Van Den Bogaert W, Lepla B, Croes K, Van de Voorde W.
Sodium nitrite (NaNO(2)) is an inorganic compound that is commonly used as a preservative (E250) in the fish and meat industry. When ingested, sodium nitrite will lead to methemoglobinemia, hypotension, and arrhythmias. An increasing trend in the use of so... (Source: SafetyLit)
Source: SafetyLit - June 26, 2023 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Peninsula drug maker's FDA lawsuit aims to stop narcolepsy drug competitor
The new drug is easier for narcolepsy patients to take, but will offer little change in price for more sodium intake, Jazz's attorneys contend. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 23, 2023 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news
FDA Approves Suflave (polyethylene glycol 3350, sodium sulfate, potassium chloride, magnesium sulfate, and sodium chloride) Colonoscopy Preparation that Tastes Similar to a Sports Drink
BRAINTREE, Mass., June 22, 2023 /PRNewswire/ -- Sebela Pharmaceuticals today announced that the U.S. Food and Drug Administration (FDA) granted approval of Suflave™ (polyethylene glycol, sodium sulfate, potassium chloride, magnesium... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - June 22, 2023 Category: Drugs & Pharmacology Source Type: news
The effectiveness of topical fluoride agents on preventing development of approximal caries in primary teeth: a randomized clinical trial Parach Sirivichayakul,
ConclusionAt
18-month follow-up, after adjusting for confounding factors and
clustering effect, there were no statistically significant differences
in preventing of approximal caries development between the semiannual
application of 5%NaF, 38%SDF, or placebo.Trial registrationThe study was registered in the Thai Clinical Trials Registry under the number TCTR20190315003 on 15/03/2019. (Source: Dental Technology Blog)
Source: Dental Technology Blog - June 13, 2023 Category: Dentistry Source Type: news
NPPA fixes retail prices of 23 drug formulations
Similarly, the retail price of one tablet of Telmisartan, Chlorthalidone& Cilnidipine tablets at Rs 13.17. The retail price of one tablet of pain reliever medication Trypsin, Bromelain, Rutoside Trihydrate and Diclofenac Sodium tablets has been fixed at Rs 20.51. The NPPA said it has also revised ceiling price of 15 scheduled formulations under Drugs (Prices Control) Order, 2013 (NLEM 2022). (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 9, 2023 Category: Pharmaceuticals Source Type: news
Big Boost in Sodium Excretion With HF Diuretic Protocol Big Boost in Sodium Excretion With HF Diuretic Protocol
Current HFA-ESC guidelines for diuretics in acute heart failure led to significant increases in natriuresis and diuresis over 2 days compared with usual care, in ENACT-HF.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - June 8, 2023 Category: Cardiology Tags: Cardiology News Source Type: news
