Seasonal Affective Disorder Research 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats
Chronobiol Int. 2023 Dec 4:1-12. doi: 10.1080/07420528.2023.2288223. Online ahead of print.ABSTRACTSeasonal affective disorder (SAD) is a recurrent depression triggered by exposure to short photoperiods, with a subset of patients reporting hypersomnia, increased appetite, and carbohydrate craving. Dysfunction of the microbiota - gut - brain axis is frequently associated with depressive disorders, but its role in SAD is unknown. Nile grass rats (Arvicanthis niloticus) are potentially useful for exploring the pathophysiology of SAD, as they are diurnal and have been found to exhibit anhedonia and affective-like behavior in r...
Source: Chronobiology International - December 4, 2023 Category: Biology Authors: Anusha Shankar Cole K Deal Shelby McCahon Kyle Callegari Taylor Seitz Lily Yan Devin M Drown Cory T Williams Source Type: research
SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats
Chronobiol Int. 2023 Dec 4:1-12. doi: 10.1080/07420528.2023.2288223. Online ahead of print.ABSTRACTSeasonal affective disorder (SAD) is a recurrent depression triggered by exposure to short photoperiods, with a subset of patients reporting hypersomnia, increased appetite, and carbohydrate craving. Dysfunction of the microbiota - gut - brain axis is frequently associated with depressive disorders, but its role in SAD is unknown. Nile grass rats (Arvicanthis niloticus) are potentially useful for exploring the pathophysiology of SAD, as they are diurnal and have been found to exhibit anhedonia and affective-like behavior in r...
Source: Chronobiology International - December 4, 2023 Category: Biology Authors: Anusha Shankar Cole K Deal Shelby McCahon Kyle Callegari Taylor Seitz Lily Yan Devin M Drown Cory T Williams Source Type: research
SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats
Chronobiol Int. 2023 Dec 4:1-12. doi: 10.1080/07420528.2023.2288223. Online ahead of print.ABSTRACTSeasonal affective disorder (SAD) is a recurrent depression triggered by exposure to short photoperiods, with a subset of patients reporting hypersomnia, increased appetite, and carbohydrate craving. Dysfunction of the microbiota - gut - brain axis is frequently associated with depressive disorders, but its role in SAD is unknown. Nile grass rats (Arvicanthis niloticus) are potentially useful for exploring the pathophysiology of SAD, as they are diurnal and have been found to exhibit anhedonia and affective-like behavior in r...
Source: Chronobiology International - December 4, 2023 Category: Biology Authors: Anusha Shankar Cole K Deal Shelby McCahon Kyle Callegari Taylor Seitz Lily Yan Devin M Drown Cory T Williams Source Type: research
SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats
Chronobiol Int. 2023 Dec 4:1-12. doi: 10.1080/07420528.2023.2288223. Online ahead of print.ABSTRACTSeasonal affective disorder (SAD) is a recurrent depression triggered by exposure to short photoperiods, with a subset of patients reporting hypersomnia, increased appetite, and carbohydrate craving. Dysfunction of the microbiota - gut - brain axis is frequently associated with depressive disorders, but its role in SAD is unknown. Nile grass rats (Arvicanthis niloticus) are potentially useful for exploring the pathophysiology of SAD, as they are diurnal and have been found to exhibit anhedonia and affective-like behavior in r...
Source: Chronobiology International - December 4, 2023 Category: Biology Authors: Anusha Shankar Cole K Deal Shelby McCahon Kyle Callegari Taylor Seitz Lily Yan Devin M Drown Cory T Williams Source Type: research
SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats
Chronobiol Int. 2023 Dec 4:1-12. doi: 10.1080/07420528.2023.2288223. Online ahead of print.ABSTRACTSeasonal affective disorder (SAD) is a recurrent depression triggered by exposure to short photoperiods, with a subset of patients reporting hypersomnia, increased appetite, and carbohydrate craving. Dysfunction of the microbiota - gut - brain axis is frequently associated with depressive disorders, but its role in SAD is unknown. Nile grass rats (Arvicanthis niloticus) are potentially useful for exploring the pathophysiology of SAD, as they are diurnal and have been found to exhibit anhedonia and affective-like behavior in r...
Source: Chronobiology International - December 4, 2023 Category: Biology Authors: Anusha Shankar Cole K Deal Shelby McCahon Kyle Callegari Taylor Seitz Lily Yan Devin M Drown Cory T Williams Source Type: research
SAD rats: Effects of short photoperiod and carbohydrate consumption on sleep, liver steatosis, and the gut microbiome in diurnal grass rats
Chronobiol Int. 2023 Dec 4:1-12. doi: 10.1080/07420528.2023.2288223. Online ahead of print.ABSTRACTSeasonal affective disorder (SAD) is a recurrent depression triggered by exposure to short photoperiods, with a subset of patients reporting hypersomnia, increased appetite, and carbohydrate craving. Dysfunction of the microbiota - gut - brain axis is frequently associated with depressive disorders, but its role in SAD is unknown. Nile grass rats (Arvicanthis niloticus) are potentially useful for exploring the pathophysiology of SAD, as they are diurnal and have been found to exhibit anhedonia and affective-like behavior in r...
Source: Chronobiology International - December 4, 2023 Category: Biology Authors: Anusha Shankar Cole K Deal Shelby McCahon Kyle Callegari Taylor Seitz Lily Yan Devin M Drown Cory T Williams Source Type: research
Evaluation of rhodanine indolinones as AANAT inhibitors
ChemMedChem. 2023 Nov 20:e202300567. doi: 10.1002/cmdc.202300567. Online ahead of print.ABSTRACTCircadian rhythm (CR) dysregulation negatively impacts health and contributes to mental disorders. The role of melatonin, a hormone intricately linked to CR, is still a subject of active study. The enzyme arylalkylamine N-acetyltransferase (AANAT) is responsible for melatonin synthesis, and it is a potential target for disorders that involve abnormally high melatonin levels, such as seasonal affective disorder (SAD). Current AANAT inhibitors suffer from poor cell permeability, selectivity, and/or potency. To address the latter, ...
Source: ChemMedChem - November 20, 2023 Category: Chemistry Authors: Mackenzie Hagemeister Luke Hamilton Nicole Wandrey Mackinzi Hill Emery Mounce Noah Mosel Katie Lytle Makenna Redinger Jake Boley Nathan Fancher Alexis Haynes Ianna Fill Philip A Cole Evan Hill Michael Moxley Allen Thomas Source Type: research
Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen
This study utilised a combination of in vitro transcriptomics and in silico analysis with the BROAD Institute's Connectivity Map to identify drugs that can be repurposed to treat psychiatric disorders. Human neuronal (NT2-N) cells were treated with a combination of atypical antipsychotic drugs commonly used to treat psychiatric disorders (such as schizophrenia, bipolar disorder, and major depressive disorder), and differential gene expression was analysed. Biological pathways with an increased gene expression included circadian rhythm and vascular endothelial growth factor signalling, while the adherens junction and cell c...
Source: Cell Research - November 3, 2023 Category: Cytology Authors: Chiara C Bortolasci Emily J Jaehne Dami án Hernández Briana Spolding Timothy Connor Bruna Panizzutti Olivia M Dean Tamsyn M Crowley Alison R Yung Laura Gray Jee Hyun Kim Maarten van den Buuse Michael Berk Ken Walder Source Type: research
Metergoline Shares Properties with Atypical Antipsychotic Drugs Identified by Gene Expression Signature Screen
This study utilised a combination of in vitro transcriptomics and in silico analysis with the BROAD Institute's Connectivity Map to identify drugs that can be repurposed to treat psychiatric disorders. Human neuronal (NT2-N) cells were treated with a combination of atypical antipsychotic drugs commonly used to treat psychiatric disorders (such as schizophrenia, bipolar disorder, and major depressive disorder), and differential gene expression was analysed. Biological pathways with an increased gene expression included circadian rhythm and vascular endothelial growth factor signalling, while the adherens junction and cell c...
Source: Cell Research - November 3, 2023 Category: Cytology Authors: Chiara C Bortolasci Emily J Jaehne Dami án Hernández Briana Spolding Timothy Connor Bruna Panizzutti Olivia M Dean Tamsyn M Crowley Alison R Yung Laura Gray Jee Hyun Kim Maarten van den Buuse Michael Berk Ken Walder Source Type: research
Illuminating the way: the role of bright light therapy in the treatment of depression
Expert Rev Neurother. 2023 Oct 26:1-15. doi: 10.1080/14737175.2023.2273396. Online ahead of print.ABSTRACTINTRODUCTION: Despite the growing number of different therapeutic options, treatment of depression is still a challenge. A broader perspective reveals the benefits of bright light therapy (BLT). It stimulates intrinsically photosensitive retinal ganglion cells, which induces a complex cascade of events, including alterations in melatonergic, neurotrophic, GABAergic, glutamatergic, noradrenergic, serotonergic systems, and HPA axis, suggesting that BLT effects expand beyond the circadian pacemaker.AREAS COVERED: In this ...
Source: Expert Review of Neurotherapeutics - October 26, 2023 Category: Neurology Authors: Biljana Kosanovic Rajacic Marina Sagud Nela Pivac Drazen Begic Source Type: research
