Elucidating treatment targets and mediators within a confirmatory efficacy trial: study protocol for a randomized controlled trial of cognitive-behavioral therapy vs. light therapy for winter depression
This study is a confirmatory efficacy trial of two treatments for winter seasonal affective disorder (SAD): SAD-tailored group cognitive-behavioral therapy (CBT-SAD) and light therapy (LT). In our previous efficacy trial, post-treatment outcomes for CBT-SAD and LT were very similar, but CBT-SAD was associated with fewer depression recurrences two winters later than LT (27.3% in CBT-SAD vs. 45.6% in LT). CBT-SAD engaged and altered a specific mechanism of action, seasonal beliefs, which mediated CBT-SAD ’s acute antidepressant effects and CBT-SAD’s enduring benefit over LT. Seasonal beliefs are theoretically distinct fr...
Source: Trials - May 12, 2022 Category: Research Source Type: clinical trials

Infrared Photomodulation Therapy for Seasonal Affective Disorder
Condition:   Seasonal Affective Disorder Intervention:   Device: Joovv Mini Sponsors:   ProofPilot;   Joovv Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 31, 2020 Category: Research Source Type: clinical trials

Seasonal Affective Disorder and Visual Impairment
Conditions:   Seasonal Affective Disorder;   Visual Impairment Intervention:   Device: light therapy Sponsors:   Psychiatric Centre Rigshospitalet;   Glostrup University Hospital, Copenhagen Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2018 Category: Research Source Type: clinical trials