Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research
Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461 (Source: Neurochirurgie)
Source: Neurochirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research
Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research
Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461 (Source: Neurochirurgie)
Source: Neurochirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research
Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research
Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461 (Source: Neurochirurgie)
Source: Neurochirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research
Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research
Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy
CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461 (Source: Neurochirurgie)
Source: Neurochirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research
Understanding how the research question impacts trial design: Examples from discectomy trials
CONCLUSION: Theoretical research questions inspired from observational data can lead to erroneous trial design. Prospective randomized trials impact practice immediately: they are unique occasions to address clinical problems and optimize care under uncertainty in real time. However, they require the research question to be formulated with great care.PMID:37413815 | DOI:10.1016/j.neuchi.2023.101460 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - July 6, 2023 Category: Neurosurgery Authors: J Raymond V K Y Chan T E Darsaut Source Type: research
Understanding how the research question impacts trial design: Examples from discectomy trials
CONCLUSION: Theoretical research questions inspired from observational data can lead to erroneous trial design. Prospective randomized trials impact practice immediately: they are unique occasions to address clinical problems and optimize care under uncertainty in real time. However, they require the research question to be formulated with great care.PMID:37413815 | DOI:10.1016/j.neuchi.2023.101460 (Source: Neurochirurgie)
Source: Neurochirurgie - July 6, 2023 Category: Neurosurgery Authors: J Raymond V K Y Chan T E Darsaut Source Type: research
Understanding how the research question impacts trial design: Examples from discectomy trials
CONCLUSION: Theoretical research questions inspired from observational data can lead to erroneous trial design. Prospective randomized trials impact practice immediately: they are unique occasions to address clinical problems and optimize care under uncertainty in real time. However, they require the research question to be formulated with great care.PMID:37413815 | DOI:10.1016/j.neuchi.2023.101460 (Source: Neuro-Chirurgie)
Source: Neuro-Chirurgie - July 6, 2023 Category: Neurosurgery Authors: J Raymond V K Y Chan T E Darsaut Source Type: research
Understanding how the research question impacts trial design: Examples from discectomy trials
CONCLUSION: Theoretical research questions inspired from observational data can lead to erroneous trial design. Prospective randomized trials impact practice immediately: they are unique occasions to address clinical problems and optimize care under uncertainty in real time. However, they require the research question to be formulated with great care.PMID:37413815 | DOI:10.1016/j.neuchi.2023.101460 (Source: Neurochirurgie)
Source: Neurochirurgie - July 6, 2023 Category: Neurosurgery Authors: J Raymond V K Y Chan T E Darsaut Source Type: research
Sex life and low back pain: The impact of intradiscal ozone therapy in patients with herniated lumbar disc
CONCLUSIONS: Percutaneous intradiscal ozone therapy is highly effective in reducing sexual impairment due to lumbar disc herniation, and the improvement is faster in older patients and in the case of L3-L4 disc involvement.PMID:37321647 | DOI:10.1177/15910199231183108 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - June 15, 2023 Category: Radiology Authors: Francesco Somma Alberto Negro Mario Tortora Laura Gemini Gianvito Pace Fabrizio Fasano Valeria Piscitelli Carmine Sicignano Mariaevelina Prudente Arturo De Falco Alessandro Villa Marina Lugar à Giovanna Pezzullo Vincenzo D'Agostino Gianluca Gatta Source Type: research
Physiotherapy Screening for Referral of a Patient with Peripheral Arterial Disease Masquerading as Sciatica: A Case Report
Healthcare (Basel). 2023 May 24;11(11):1527. doi: 10.3390/healthcare11111527.ABSTRACTMany causes potentially underline pain in the lower extremities, presenting a real challenge for primary care clinicians in the recognition of the source of the patient's complaints. Peripheral arterial disease (PAD) is defined as a total or partial blockage of the vessels that supply blood from the heart to the periphery. PAD of the lower extremities may masquerade as lumbosacral radiculopathy (LSR)-a common source of leg pain. Physiotherapists should be able to screen for PAD in people presenting with pain in the lower extremities. Failu...
Source: Pain Physician - June 10, 2023 Category: Anesthesiology Authors: Daniel Feller Andrea Giudice Giorgio Maritati Filippo Maselli Giacomo Rossettini Roberto Meroni Graziana Lullo Nathan Hutting Firas Mourad Source Type: research
