Understanding crossovers and potential ways to mitigate the problem: Lessons from influential trials on lumbar microdiscectomy

CONCLUSION: Non-adherence to randomly allocated management options can deprive trials of the statistical power needed to inform clinical care. Crossovers and ways to mitigate related problems should be anticipated at the time of trial design.PMID:37450957 | DOI:10.1016/j.neuchi.2023.101461

Source: Neuro-Chirurgie - July 14, 2023 Category: Neurosurgery Authors: V K Y Chan T E Darsaut C S Bailey J Raymond Source Type: research