Understanding how the research question impacts trial design: Examples from discectomy trials

CONCLUSION: Theoretical research questions inspired from observational data can lead to erroneous trial design. Prospective randomized trials impact practice immediately: they are unique occasions to address clinical problems and optimize care under uncertainty in real time. However, they require the research question to be formulated with great care.PMID:37413815 | DOI:10.1016/j.neuchi.2023.101460

Source: Neurochirurgie - July 6, 2023 Category: Neurosurgery Authors: J Raymond V K Y Chan T E Darsaut Source Type: research