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Infectious Disease: Gastroenteritis
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Total 36194 results found since Jan 2013.
Toll-like receptor-immobilized carbon paste electrodes with plasma functionalized amine termination: Towards real-time electrochemical based triaging of gram-negative bacteria
Biosens Bioelectron. 2023 Sep 6;241:115674. doi: 10.1016/j.bios.2023.115674. Online ahead of print.ABSTRACTChronic wounds caused due to bacterial biofilms are detrimental to a patient, and an immediate diagnosis of these bacteria can aid in an effective treatment, which is still an unmet clinical need. An instant and accurate identification of bacterial type could be made by utilizing the Toll-Like Receptors (TLRs) combined with Myeloid Differentiation factor 2 (MD-2). Given this, we have developed an electrochemical sensing platform to identify the gram-negative (gram-ve) bacteria using TLR4/MD-2 complex. The nonthermal p...
Source: Biosensors and Bioelectronics - September 17, 2023 Category: Biotechnology Authors: Rahul Gangwar Debjyoti Ray Sajmina Khatun Challapalli Subrahmanyam Aravind Kumar Rengan Siva Rama Krishna Vanjari Source Type: research
Discovery of 1,2-diaryl-3-oxopyrazolidin-4-carboxamides as a new class of MurA enzyme inhibitors and characterization of their antibacterial activity
Eur J Med Chem. 2023 Sep 4;261:115789. doi: 10.1016/j.ejmech.2023.115789. Online ahead of print.ABSTRACTThe cytoplasmic steps of peptidoglycan synthesis represent an important targeted pathway for development of new antibiotics. Herein, we report the synthesis of novel 3-oxopyrazolidin-4-carboxamide derivatives with variable amide side chains as potential antibacterial agents targeting MurA enzyme, the first committed enzyme in these cytosolic steps. Compounds 15 (isoindoline-1,3-dione-5-yl), 16 (4-(1H-pyrazol-4-yl)phenyl), 20 (5-cyanothiazol-2-yl), 21 and 31 (5-nitrothiazol-2-yl derivatives) exhibited the most potent MurA...
Source: European Journal of Medicinal Chemistry - September 17, 2023 Category: Chemistry Authors: Reem A Wagdy Nader S Abutaleb Reem K Fathalla Yehia Elgammal Stefanie Weck Rusha Pal Patrick D Fischer Christian Ducho Ashraf H Abadi Mohamed N Seleem Matthias Engel Mohammad Abdel-Halim Source Type: research
Exploring the translational gap of a novel class of Escherichia coli IspE inhibitors
ChemMedChem. 2023 Sep 17:e202300346. doi: 10.1002/cmdc.202300346. Online ahead of print.ABSTRACTDiscovery of novel antibiotics needs multidiscliplinary approaches to gain target enzyme and bacterial activity while aiming for selectivity over mammalian cells. Here we report a multi-parameter optimisation of a fragment-like hit that was identified through a structure-based virtual screening campaign on Escherichia coli IspE crystal structure. Subsequent medicinal chemistry design resulted in a novel class of E. coli IspE inhibitors, exhibiting activity also against the more pathogenic bacteria Pseudomonas aeruginosa and Acin...
Source: ChemMedChem - September 17, 2023 Category: Chemistry Authors: Henni-Karoliina Ropponen Eleonora Diamanti Sandra Johannsen Boris Illarionov Rawia Hamid Miriam Jaki Peter Sass Markus Fischer J örg Haupenthal Anna Katharina Herta Hirsch Source Type: research
A novel multifunctional chitosan-gelatin/carboxymethyl cellulose-alginate bilayer hydrogel containing human placenta extract for accelerating full-thickness wound healing
This study presents a multifunctional bi-layer hydrogel incorporating HPE for accelerating full-thickness wound healing through sustained HPE release, inhibition of bacteria invasion, and promotion of cell proliferation. The upper layer of the scaffold, known as the dressing layer, is composed of carboxymethyl cellulose and sodium alginate, serving as a supportive layer for cell proliferation. The under layer, referred to as the regenerative layer, is composed of chitosan and gelatin, providing an extracellular matrix-like, porous, moist, and antibacterial environment for cell growth. The scaffold was optimized to replicat...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Saeed Seifi Amir Shamloo Sayed Navid Tavoosi Aram Almasi-Jaf Hossein Shaygani Mohammad Reza Sayah Source Type: research
Carboxymethyl chitosan-TK resistant starch complex ameliorates type 2 diabetes by regulating the gut microbiota
Int J Biol Macromol. 2023 Sep 15:126930. doi: 10.1016/j.ijbiomac.2023.126930. Online ahead of print.ABSTRACTCarboxymethyl chitosan and resistant starch exhibit good performance in diabetes regulation. We prepared carboxymethyl chitosan - resistant starch complex. Test the properties of composite resistant starch by using X-ray diffraction, water contact angle, infrared spectroscopy, and scanning electron microscopy, interactions with intestinal microbiota and mouse experiments were also conducted. The results indicated that the composite resistant starch had a good effect on promoting the proliferation of probiotics on Bif...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Xin Pan Pei Liu Ye-Jun Zhang Hao-Kuang Zhang Hao Wei Jing-Yi Jiang None Hui-Yan Er-Xin Shang Wei-Wen Li Yiwei Wang Jin-Ao Duan Source Type: research
Green synthesis of multifunctional zinc oxide nanoparticles from cordia myxa gum; and their catalytic reduction of nitrophenol, anticancer and antimicrobial activity
This study uses CMX gum as a bioreduction to produce multifunctional, environmentally friendly zinc-oxide nanocomposites (ZnO NPs). The process involves a low reaction time and temperature and utilizes CMX as a reducing and stabilizing agent. The structural, morphological, and optical properties of the CMX-ZnO nanocomposite were characterized. The biosynthetic CMX-ZnO NPs exhibited robust catalytic activity and recycling capacity for rapidly oxidizing hazardous p-NPs. The complete reduction of 4-NP to CMX-ZnO NPs in excess NaBH4 was achieved within 15 min, with recyclability and pseudo-first-order kinetics with a rate cons...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Kasula Nagaraja O H Tae Hwan Source Type: research
Corrigendum to "Validation of PCR methods for confirmation and species identification of thermotolerant Campylobacter as part of EN ISO 10272 - Microbiology of the food chain - Horizontal method for detection and enumeration of Campylobacter spp." Int. J. Food Microbiol. 388 (2023) 110064
Int J Food Microbiol. 2023 Sep 15:110393. doi: 10.1016/j.ijfoodmicro.2023.110393. Online ahead of print.NO ABSTRACTPMID:37718139 | DOI:10.1016/j.ijfoodmicro.2023.110393
Source: International Journal of Food Microbiology - September 17, 2023 Category: Food Science Authors: Sevinc Ferrari Ásgeir Ástvaldsson Therese Jernberg Kerstin Stingl Ute Messelh äußer Hanna Skarin Source Type: research
Exploring the translational gap of a novel class of Escherichia coli IspE inhibitors
ChemMedChem. 2023 Sep 17:e202300346. doi: 10.1002/cmdc.202300346. Online ahead of print.ABSTRACTDiscovery of novel antibiotics needs multidiscliplinary approaches to gain target enzyme and bacterial activity while aiming for selectivity over mammalian cells. Here we report a multi-parameter optimisation of a fragment-like hit that was identified through a structure-based virtual screening campaign on Escherichia coli IspE crystal structure. Subsequent medicinal chemistry design resulted in a novel class of E. coli IspE inhibitors, exhibiting activity also against the more pathogenic bacteria Pseudomonas aeruginosa and Acin...
Source: ChemMedChem - September 17, 2023 Category: Chemistry Authors: Henni-Karoliina Ropponen Eleonora Diamanti Sandra Johannsen Boris Illarionov Rawia Hamid Miriam Jaki Peter Sass Markus Fischer J örg Haupenthal Anna Katharina Herta Hirsch Source Type: research
Efficient biotransformation of docosahexaenoic acid-rich oils into the lipid mediator resolvin D5 by cells expressing 15S-lipoxygenase using a bioreactor
This study will contribute to the large-scale production of SPMs from oils.PMID:37717704 | DOI:10.1016/j.biortech.2023.129750
Source: Bioresource Technology - September 17, 2023 Category: Biotechnology Authors: Jin Lee Hyun-Ah Park Kyung-Chul Shin Jin-Byung Park Deok-Kun Oh Source Type: research
Toll-like receptor-immobilized carbon paste electrodes with plasma functionalized amine termination: Towards real-time electrochemical based triaging of gram-negative bacteria
Biosens Bioelectron. 2023 Sep 6;241:115674. doi: 10.1016/j.bios.2023.115674. Online ahead of print.ABSTRACTChronic wounds caused due to bacterial biofilms are detrimental to a patient, and an immediate diagnosis of these bacteria can aid in an effective treatment, which is still an unmet clinical need. An instant and accurate identification of bacterial type could be made by utilizing the Toll-Like Receptors (TLRs) combined with Myeloid Differentiation factor 2 (MD-2). Given this, we have developed an electrochemical sensing platform to identify the gram-negative (gram-ve) bacteria using TLR4/MD-2 complex. The nonthermal p...
Source: Biosensors and Bioelectronics - September 17, 2023 Category: Biotechnology Authors: Rahul Gangwar Debjyoti Ray Sajmina Khatun Challapalli Subrahmanyam Aravind Kumar Rengan Siva Rama Krishna Vanjari Source Type: research
Changes of Gut Microbiota in Maintenance Hemodialysis Patients and Their Impact on Patient's Microinflammation Status
In conclusion, patients with maintenance hemodialysis for CKD commonly exhibit gut microbiota dysbiosis and varying degrees of low-grade inflammation. Compared to healthy individuals, maintenance hemodialysis patients with CKD have lower levels of Bifidobacterium and Lactobacillus and higher levels of Escherichia coli and Enterococcus in their gut. Bifidobacterium, Lactobacillus, Escherichia coli, and Enterococcus all have a certain impact on the low-grade inflammation status of patients with maintenance hemodialysis for CKD.PMID:37715414 | DOI:10.14715/cmb/2023.69.8.15
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Xiaopan Zhang Yilin Wang Ying Yin Bo Sun Guangren Chen Fengling Chen Source Type: research
Characterization of Multiple Resistance Genes of Escherichia coli Strains Isolated from Food and Clinical Samples
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):118-126. doi: 10.14715/cmb/2023.69.7.19.ABSTRACTMulti-drug resistance (MDR), which is formed by the development of antimicrobial resistance, which is one of the defense mechanisms in bacteria, has pushed human beings to constantly seek new antimicrobial agents in the fight against these microorganisms. Speed and precision are very important in identifying resistance in strains with MDR that reach humans in an open system through the consumption of contaminated food or water. The main aim of this study was the molecular characterization of ESBL gene variants (blaTEM, blaOXA,...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Birg ül Yelimlibağ Muhsin Aydin Source Type: research
Effects of in vitro fermentation of Atractylodes chinensis (DC.) Koidz. polysaccharide on fecal microbiota and metabolites in patients with type 2 diabetes mellitus
This study has laid a theoretical foundation for AKP application in functional foods.PMID:37716665 | DOI:10.1016/j.ijbiomac.2023.126860
Source: International Journal of Biological Macromolecules - September 16, 2023 Category: Biochemistry Authors: Xin Zhang Qian Ma Lina Jia Hongpeng He Tongcun Zhang Weiguo Jia Liying Zhu Wei Qi Nan Wang Source Type: research
High-throughput sequencing analysis of the characteristics of the gut microbiota in aged patients with sarcopenia
CONCLUSIONS: In this study, we have identified changes in the gut microbiota of sarcopenic individuals, which were linked to the loss of muscle mass and function. Escherichia-Shigella is a conditional pathogen of sarcopenic patients, and its levels are found to have a significant negative correlation with muscle mass.PMID:37716483 | DOI:10.1016/j.exger.2023.112287
Source: Experimental Gerontology - September 16, 2023 Category: Geriatrics Authors: Yiyi Zhang Ying Zhu Qin Guo Wei Wang Lei Zhang Source Type: research
Vaginal Microbiota Profile in first-trimester miscarriages cases
In this study, 435 vaginal swabs were collected from aborted women in Maternity Teaching Hospitals in Erbil and Shahid Dr. Khalid Hospital in Koya. We characterized the vaginal microbiota diversity and composition in first-trimester abortion and investigated the association between bacterial vaginosis and abortion before 12 weeks. Cultural, morphological, and biochemical characteristics for each bacterial genus were discovered, and VITEK-2 system was used to identify isolated bacteria. Samples from each type of bacteria were selected for sequencing utilizing 16 rRNA genes examining V4-V8 region for bacterial profiles. Bact...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Saman Rafeeq Abdulla Sarmad Raheem Kareem Ayad H Hasan Source Type: research
