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Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil Fumarate
AAPS PharmSciTech. 2023 Aug 11;24(6):171. doi: 10.1208/s12249-023-02623-7.ABSTRACTThe aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in hospitals along with other antiviral drugs. In order to obtain a consistent quality of printlets with desired properties, it is important to understand certain critical quality attributes for their main and interactions effect. The printlets were optimized by Box-Behnken's design of the experiment by varying...
Source: AAPS PharmSciTech - August 11, 2023 Category: Drugs & Pharmacology Authors: Canberk Kayalar Ziyaur Rahman Eman M Mohamed Sathish Dharani Tahir Khuroo Nada Helal Mathew A Kuttolamadom Mansoor A Khan Source Type: research
Supplement use in relation to dietary intake in pregnancy - an analysis of the Swedish GraviD cohort
In conclusion, supplement use contributed substantially to reaching RI for vitamin D, folate, and iron. Supplement users had a higher dietary intake of several nutrients than non-users. This highlights that non-supplement users are at risk of inadequate nutrient intakes during pregnancy, suggesting a need for heightened awareness of nutritional adequacy for pregnant women.PMID:37565530 | DOI:10.1017/S0007114523001794
Source: The British Journal of Nutrition - August 11, 2023 Category: Nutrition Authors: Mathilda Forsby Anna Winkvist Linnea B ärebring Hanna Augustin Source Type: research
Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil Fumarate
AAPS PharmSciTech. 2023 Aug 11;24(6):171. doi: 10.1208/s12249-023-02623-7.ABSTRACTThe aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in hospitals along with other antiviral drugs. In order to obtain a consistent quality of printlets with desired properties, it is important to understand certain critical quality attributes for their main and interactions effect. The printlets were optimized by Box-Behnken's design of the experiment by varying...
Source: AAPS PharmSciTech - August 11, 2023 Category: Drugs & Pharmacology Authors: Canberk Kayalar Ziyaur Rahman Eman M Mohamed Sathish Dharani Tahir Khuroo Nada Helal Mathew A Kuttolamadom Mansoor A Khan Source Type: research
Supplement use in relation to dietary intake in pregnancy - an analysis of the Swedish GraviD cohort
In conclusion, supplement use contributed substantially to reaching RI for vitamin D, folate, and iron. Supplement users had a higher dietary intake of several nutrients than non-users. This highlights that non-supplement users are at risk of inadequate nutrient intakes during pregnancy, suggesting a need for heightened awareness of nutritional adequacy for pregnant women.PMID:37565530 | DOI:10.1017/S0007114523001794
Source: The British Journal of Nutrition - August 11, 2023 Category: Nutrition Authors: Mathilda Forsby Anna Winkvist Linnea B ärebring Hanna Augustin Source Type: research
Relation between Biochemical Parameters and Bone Density in Postmenopausal Women with Osteoporosis
CONCLUSION: There was no significant relationship between the values of calcium, phosphorus, alkaline phosphatase, vitamin D, and magnesium parameters and bone density (spine and hip) in postmenopausal women with osteopenia or osteoporosis.PMID:37564448 | PMC:PMC10410433 | DOI:10.4103/abr.abr_135_22
Source: Biomed Res - August 11, 2023 Category: Research Authors: Mohammad Reza Salamat Shokouh Momeni Ali Asghar Rastegari Source Type: research
Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil Fumarate
AAPS PharmSciTech. 2023 Aug 11;24(6):171. doi: 10.1208/s12249-023-02623-7.ABSTRACTThe aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in hospitals along with other antiviral drugs. In order to obtain a consistent quality of printlets with desired properties, it is important to understand certain critical quality attributes for their main and interactions effect. The printlets were optimized by Box-Behnken's design of the experiment by varying...
Source: AAPS PharmSciTech - August 11, 2023 Category: Drugs & Pharmacology Authors: Canberk Kayalar Ziyaur Rahman Eman M Mohamed Sathish Dharani Tahir Khuroo Nada Helal Mathew A Kuttolamadom Mansoor A Khan Source Type: research
Relation between Biochemical Parameters and Bone Density in Postmenopausal Women with Osteoporosis
CONCLUSION: There was no significant relationship between the values of calcium, phosphorus, alkaline phosphatase, vitamin D, and magnesium parameters and bone density (spine and hip) in postmenopausal women with osteopenia or osteoporosis.PMID:37564448 | PMC:PMC10410433 | DOI:10.4103/abr.abr_135_22
Source: Cell Research - August 11, 2023 Category: Cytology Authors: Mohammad Reza Salamat Shokouh Momeni Ali Asghar Rastegari Source Type: research
Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil Fumarate
AAPS PharmSciTech. 2023 Aug 11;24(6):171. doi: 10.1208/s12249-023-02623-7.ABSTRACTThe aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in hospitals along with other antiviral drugs. In order to obtain a consistent quality of printlets with desired properties, it is important to understand certain critical quality attributes for their main and interactions effect. The printlets were optimized by Box-Behnken's design of the experiment by varying...
Source: AAPS PharmSciTech - August 11, 2023 Category: Drugs & Pharmacology Authors: Canberk Kayalar Ziyaur Rahman Eman M Mohamed Sathish Dharani Tahir Khuroo Nada Helal Mathew A Kuttolamadom Mansoor A Khan Source Type: research
Chemical characteristics of wildfire ash across the globe and their environmental and socio-economic implications
Environ Int. 2023 Jun 25;178:108065. doi: 10.1016/j.envint.2023.108065. Online ahead of print.ABSTRACTThe mobilisation of potentially harmful chemical constituents in wildfire ash can be a major consequence of wildfires, posing widespread societal risks. Knowledge of wildfire ash chemical composition is crucial to anticipate and mitigate these risks. Here we present a comprehensive dataset on the chemical characteristics of a wide range of wildfire ashes (42 types and a total of 148 samples) from wildfires across the globe and examine their potential societal and environmental implications. An extensive review of studies a...
Source: Environment International - August 10, 2023 Category: Environmental Health Authors: C S ánchez-García C Sant ín J Neris G Sigmund X L Otero J Manley G Gonz ález-Rodríguez C M Belcher A Cerd à A L Marcotte S F Murphy C C Rhoades G Sheridan T Strydom P R Robichaud S H Doerr Source Type: research
Development and validation of a risk prediction nomogram for serious arrhythmias in acute digoxin toxicity among pediatrics: A multicenter study
Toxicon. 2023 Aug 7:107241. doi: 10.1016/j.toxicon.2023.107241. Online ahead of print.ABSTRACTDigoxin is a cardiac glycoside obtained from the leaves of the foxglove plant, Digitalis lanata. Several studies have described the safety of digoxin in various life-threatening events, notably cardiac arrhythmias. Early identification of high-risk patients and subsequent initiation of the utmost medical care are associated with a better prognosis. The assessment of serum digoxin levels, which is not always convenient, is the only tool used to evaluate the severity of digoxin exposure. However, the feasibility of this tool, partic...
Source: Toxicon - August 9, 2023 Category: Toxicology Authors: Dina El Gameel Asmaa Fady Sharif Osama Shoeib Elsayed Ibrahim Elgebally Manar Maher Fayed Source Type: research
Simultaneous recycling of waste solar panels and treatment of persistent organic compounds via supercritical water technology
Environ Pollut. 2023 Aug 7:122331. doi: 10.1016/j.envpol.2023.122331. Online ahead of print.ABSTRACTThe study addresses the application of the supercritical water technology in the simultaneous recycling of obsolete solar panels and treatment of persistent organic compounds. The obsolete solar panels samples were characterized by TEM-EDS, SEM, TG-DTA, XRD, WDXRF, MP-AES and elemental analysis. Initially, the optimized parameters for the degradation of solid organic polymers present in residual solar panels via oxidation in supercritical water were defined by an experimental design. Under optimized conditions, 550 °C, reac...
Source: Environmental Pollution - August 9, 2023 Category: Environmental Health Authors: Mariana Bisinotto Pereira Guilherme Botelho Meireles de Souza Denise Crocce Romano Espinosa Leandro V Pav ão Christian Gon çalves Alonso Vladimir Ferreira Cabral Lucio Cardozo-Filho Source Type: research
