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Total 6421 results found since Jan 2013.
Advanced effect of curcumin and resveratrol on mitigating hepatic steatosis in metabolic associated fatty liver disease via the PI3K/AKT/mTOR and HIF-1/VEGF cascade
This study aims to investigate the effect of curcumin (Cur) and resveratrol (Res) as a potential combination therapy on MAFLD. Cur, Res and Cur+Res were tested in palmitic acid (PA)-induced-HepG2 cells. MAFLD model was established using Goto-Kakizaki rats. The animals were treated with vehicle control (model group), Cur (150 mg/kg), Res (150 mg/kg), Cur+Res (150 mg/kg, 8:2, w/w), or metformin (Met, positive control, 400 mg/kg/day) via oral gavage for 4 weeks. Wistar rats were used as the control group. Network pharmacology was conducted to elucidate the molecular actions of Cur and Res, followed by q-PCR and immunoblotting...
Source: Biomed Res - August 6, 2023 Category: Research Authors: Yuhui He Huan Wang Shiling Lin Tao Chen Dennis Chang Yibin Sun Chenxiang Wang Yang Liu Yusheng Lu Jianyuan Song Shaohua Li Wen Xu Yanxiang Lin Yanfang Zheng Xian Zhou Qiumei Huang Mingqing Huang Source Type: research
Metformin-mediated epigenetic modifications in diabetes and associated conditions: biological and clinical relevance
Biochem Pharmacol. 2023 Aug 2:115732. doi: 10.1016/j.bcp.2023.115732. Online ahead of print.ABSTRACTAn intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Therefore, it is not surprising that the epigenome also plays a crucial role in the pathogenesis of T2D. Hyperglycemia can indeed trigger epigenetic modifications, thereby regulating different gene expression patterns. Such epigenetic changes can persist after normalizing serum glucose concentrations, suggesting the presence of a 'metabolic memory' of previous hyperglycemia which may...
Source: Biochemical Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Roberta Giordo Anna Maria Posadino Arduino Aleksander Mangoni Gianfranco Pintus Source Type: research
Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins
Biomed Pharmacother. 2023 Aug 1;165:115263. doi: 10.1016/j.biopha.2023.115263. Online ahead of print.ABSTRACTIn addition to the anti-diabetic effect of metformin, a growing number of studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which have potent, that can treat other disorders other than diabetes mellitus. We aimed to describe and review the protective and antidotal efficacy of metformin against biologicals, chemicals, natural, medications, pesticides, and radiation-induced toxicities. A comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 4, 2023 Category: Drugs & Pharmacology Authors: Amirhossein Malaekeh-Nikouei Sina Shokri-Naei Sobhan Karbasforoushan Hossein Bahari Vafa Baradaran Rahimi Reza Heidari Vahid Reza Askari Source Type: research
Metformin-mediated epigenetic modifications in diabetes and associated conditions: Biological and clinical relevance
Biochem Pharmacol. 2023 Aug 2;215:115732. doi: 10.1016/j.bcp.2023.115732. Online ahead of print.ABSTRACTAn intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Therefore, it is not surprising that the epigenome also plays a crucial role in the pathogenesis of T2D. Hyperglycemia can indeed trigger epigenetic modifications, thereby regulating different gene expression patterns. Such epigenetic changes can persist after normalizing serum glucose concentrations, suggesting the presence of a 'metabolic memory' of previous hyperglycemia which...
Source: Biochemical Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Roberta Giordo Anna Maria Posadino Arduino Aleksander Mangoni Gianfranco Pintus Source Type: research
Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins
Biomed Pharmacother. 2023 Aug 1;165:115263. doi: 10.1016/j.biopha.2023.115263. Online ahead of print.ABSTRACTIn addition to the anti-diabetic effect of metformin, a growing number of studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which have potent, that can treat other disorders other than diabetes mellitus. We aimed to describe and review the protective and antidotal efficacy of metformin against biologicals, chemicals, natural, medications, pesticides, and radiation-induced toxicities. A comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 4, 2023 Category: Drugs & Pharmacology Authors: Amirhossein Malaekeh-Nikouei Sina Shokri-Naei Sobhan Karbasforoushan Hossein Bahari Vafa Baradaran Rahimi Reza Heidari Vahid Reza Askari Source Type: research
The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Metformin should be considered as an efficacious adjunct to lifestyle interventions in adults with PCOS, especially for those with a higher BMI, to improve weight loss, insulin resistance and lipids.PMID:37536294 | DOI:10.1093/ejendo/lvad098
Source: European Journal of Endocrinology - August 3, 2023 Category: Endocrinology Authors: Johanna Melin Maria Forslund Simon Alesi Terhi Piltonen Daniela Romualdi Poli Mara Spritzer Chau Thien Tay Alexia Pena Selma Feldman Witchel Aya Mousa Helena Teede Source Type: research
The great obstetrical syndromes and the placenta
BJOG. 2023 Aug 2. doi: 10.1111/1471-0528.17613. Online ahead of print.ABSTRACTAlthough historically pre-eclampsia, preterm birth, abruption, fetal growth restriction and stillbirth have been viewed as clinically distinct entities, a growing body of literature has demonstrated that the placenta and its development is the root cause of many cases of these conditions. This has led to the term 'the great obstetrical syndromes' being coined to reflect this common origin. Although these conditions mostly manifest in the second half of pregnancy, a failure to complete deep placentation (the transition from histiotrophic placentat...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 2, 2023 Category: OBGYN Authors: Matthew K Hoffman Source Type: research
Women with PCOS who undergo IVF: a comprehensive review of therapeutic strategies for successful outcomes
Reprod Biol Endocrinol. 2023 Aug 1;21(1):70. doi: 10.1186/s12958-023-01120-7.ABSTRACTPolycystic ovarian syndrome (PCOS) is a widespread syndrome that poses unique challenges and constraints to the field of assisted reproductive technology. This condition is the most common cause of anovulation among infertile couples. Debate exists over the best therapeutic course of action when patients with PCOS proceed to IVF. In this review, we evaluate the best-performing and safest methods of IVF preparation, ovarian stimulation, trigger method for maturation of stimulated egg growth, and planning for embryo transfer. Pre-IVF conside...
Source: Reproductive Biology - August 1, 2023 Category: Reproduction Medicine Authors: Alexander M Kotlyar David B Seifer Source Type: research
Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy
Nat Commun. 2023 Aug 1;14(1):4622. doi: 10.1038/s41467-023-40216-x.ABSTRACTCaspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of Card9 in Apoe-/- mice as well as hematopoietic deletion in Ldlr-/- mice increases atherosclerosis. The acceleration of atherosclerosis is also observed in Apoe-/-Rag2-/-Card9-/- mice, ruling out a role for the adaptive immune system in the vascular phenotype of Card9 deficient mice. Card9 deficiency alters macrophage phenotype through CD36 overexpression with increased IL-1β...
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: Yujiao Zhang Marie Vandestienne Jean-R émi Lavillegrand Jeremie Joffre Icia Santos-Zas Aonghus Lavelle Xiaodan Zhong Wilfried Le Goff Maryse Gu érin Rida Al-Rifai Ludivine Laurans Patrick Bruneval Coralie Gu érin Marc Diedisheim Melanie Migaud Anne Pue Source Type: research
Complex Case of Skull Base Osteomyelitis Secondary to Chronic Otitis Media
We present a case of a 58-year-old male with type II diabetes managed with metformin and insulin, who presented to the clinic with left chronic otitis media, persistent drainage, a stenotic meatus, and a prior history of 3 canal wall-down mastoidectomies and antibiotic therapy. A revision tympanoplasty with mastoidectomy was performed, and during the postoperative period, the patient had persistent pain and otorrhea, which were managed with opioids and several courses of antibiotic therapy. After symptoms persisted, imaging and culture ultimately led to the diagnosis of fungal skull base osteomyelitis, which was eventually...
Source: Ear, Nose and Throat Journal - July 29, 2023 Category: ENT & OMF Authors: Masa Petrovic Hannah G Landsberger Kevin A Peng Source Type: research
