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Drug: Acetic Acid
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Total 4747 results found since Jan 2013.
Brytella acorum gen. nov., sp. nov., a novel acetic acid bacterium from sour beverages
Syst Appl Microbiol. 2023 Jul 4;46(5):126440. doi: 10.1016/j.syapm.2023.126440. Online ahead of print.ABSTRACTPolyphasic taxonomic and comparative genomic analyses revealed that a series of lambic beer isolates including strain LMG 32668T and the kombucha isolate LMG 32879 represent a novel species among the acetic acid bacteria, with Acidomonas methanolica as the nearest phylogenomic neighbor with a valid name. Overall genomic relatedness indices and phylogenomic and physiological analyses revealed that this novel species was best classified in a novel genus for which we propose the name Brytella acorum gen. nov., sp. nov...
Source: Systematic and Applied Microbiology - July 10, 2023 Category: Microbiology Authors: Atena Sadat Sombolestani Dries Bongaerts Eliza Depoorter Ilse Cleenwerck Anneleen D Wieme Scott J Britton Stefan Weckx Luc De Vuyst Peter Vandamme Source Type: research
Insights into effects of operating temperature on the removal of pharmaceuticals/pesticides/synthetic organic compounds by membrane bioreactor process
In this study, the removal efficiency and mechanism of 8 kinds of typical micropollutants by membrane bioreactor (MBR) at different temperatures (i.e. 15, 25 and 35 °C) were investigated. MBR exhibited the high removal rate (>85%) for 3 kinds of industrial synthetic organic micropollutants (i.e. bisphenol A (BPA), 4-tert-octylphenol (TB) and 4-n-nonylphenol (NP)) with similar functional groups, structures and high hydrophobicity (Log D > 3.2). However, the removal rates of ibuprofen (IBU), carbamazepine (CBZ) and sulfamethoxazole (SMX) with pharmaceutical activity showed great discrepancy (i.e. 93%, 14.2% and 29%, r...
Source: Environmental Pollution - July 8, 2023 Category: Environmental Health Authors: Qiaoying Wang Wenjia Zheng Yan Wang Tong Zhang Zhen Zhou Zhichao Wu Source Type: research
Iron mediated reductive cyclization/oxidation for the generation of chemically diverse scaffolds: An approach in drug discovery
Bioorg Chem. 2023 Jun 23;139:106698. doi: 10.1016/j.bioorg.2023.106698. Online ahead of print.ABSTRACTChemically diverse scaffolds represent a main source of biologically important starting points in drug discovery. Herein, we report the development of such diverse scaffolds from nitroarene/ nitro(hetero)arenes using a key synthetic strategy. In a pilot-scale study, the synthesis of 10 diverse scaffolds was achieved. The 1,7-phenanthroline, thiazolo[5,4-f]quinoline, 2,3-dihydro-1H-pyrrolo[2,3-g]quinoline, pyrrolo[3,2-f]quinoline, 1H-[1,4]oxazino[3,2-g]quinolin-2(3H)-one, [1,2,5]oxadiazolo[3,4-h]quinoline, 7H-pyrido[2,3-c]c...
Source: Bioorganic Chemistry - July 7, 2023 Category: Chemistry Authors: Uttam B Karale Akash Shinde Vikas R Gaikwad Saradhi Kalari Karthik Gaurishetti Mydhili Radhakrishnan Yedla Poornachandra Ramars Amanchy Sumana Chakravarty Sai Balaji Andugulapati Haridas B Rode Source Type: research
Saikosaponin A protects against uremic toxin indole ‑3 acetic acid‑induced damage to the myocardium
Mol Med Rep. 2023 Sep;28(3):159. doi: 10.3892/mmr.2023.13046. Epub 2023 Jul 7.ABSTRACTChronic kidney disease (CKD)‑associated cardiac injury is a common complication in patients with CKD. Indole‑3 acetic acid (IAA) is a uremic toxin that injures the cardiovascular system. Saikosaponin A (SSA) protects against pressure overload‑induced cardiac fibrosis. However, the role and molecular mechanisms of IAA and SSA in CKD‑associated cardiac injury remain unclear. The present study investigated the effects of IAA and SSA on CKD‑associated cardiac injury in neonatal mouse cardiomyocytes and a mouse model of CKD. The expr...
Source: Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Cheng Chen Xiaoyuan Hu Xinguang Chen Source Type: research
Low and high doses of oral maslinic acid protect against Parkinson's disease via distinct gut microbiota-related mechanisms
In conclusion, oral MA at different doses protected against PD via distinct mechanisms related to GM. Nevertheless, our study lacked in-depth investigations of the underlying mechanisms involved; future studies will be designed to further delineate the signaling pathways involved in the interactive actions between different doses of MA and GM.PMID:37418977 | DOI:10.1016/j.biopha.2023.115100
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 7, 2023 Category: Drugs & Pharmacology Authors: Xu Cao Zhong-Rui Du Xin Liu Xiong Wang Chong Li Sai-Nan Zhou Jia-Rui Liu Ping-Yi Xu Jun-Li Ye Qing Zhao Fang Zhao Ka-Hing Wong Xiao-Li Dong Source Type: research
Efficient production of high concentration monosaccharides and ethanol from poplar wood after delignification and deacetylation
Bioresour Technol. 2023 Jul 5:129459. doi: 10.1016/j.biortech.2023.129459. Online ahead of print.ABSTRACTEfficient enzymatic hydrolysis is required for production of high concentration monosaccharides and ethanol. The lignin and acetyl group in poplar can limit the enzymatic hydrolysis. However, the effect of delignification combined with deacetylation on the saccharification of poplar for high concentration monosaccharides was not clear. Herein, hydrogen peroxide-acetic acid (HPAA) was used for delignification and sodium hydroxide was used for deacetylation to enhance the hydrolyzability of poplar. Delignification with 60...
Source: Bioresource Technology - July 7, 2023 Category: Biotechnology Authors: Peiyao Wen Zhangjing Chen Zhina Lian Junhua Zhang Source Type: research
Saikosaponin A protects against uremic toxin indole ‑3 acetic acid‑induced damage to the myocardium
Mol Med Rep. 2023 Sep;28(3):159. doi: 10.3892/mmr.2023.13046. Epub 2023 Jul 7.ABSTRACTChronic kidney disease (CKD)‑associated cardiac injury is a common complication in patients with CKD. Indole‑3 acetic acid (IAA) is a uremic toxin that injures the cardiovascular system. Saikosaponin A (SSA) protects against pressure overload‑induced cardiac fibrosis. However, the role and molecular mechanisms of IAA and SSA in CKD‑associated cardiac injury remain unclear. The present study investigated the effects of IAA and SSA on CKD‑associated cardiac injury in neonatal mouse cardiomyocytes and a mouse model of CKD. The expr...
Source: Molecular Medicine - July 7, 2023 Category: Molecular Biology Authors: Cheng Chen Xiaoyuan Hu Xinguang Chen Source Type: research
Lactate formation from fructose or C1 compounds in the acetogen Acetobacterium woodii by metabolic engineering
Appl Microbiol Biotechnol. 2023 Jul 7. doi: 10.1007/s00253-023-12637-7. Online ahead of print.ABSTRACTAnaerobic, acetogenic bacteria are promising biocatalysts for a sustainable bioeconomy since they capture and convert carbon dioxide to acetic acid. Hydrogen is an intermediate in acetate formation from organic as well as C1 substrates. Here, we analyzed mutants of the model acetogen Acetobacterium woodii in which either one of the two hydrogenases or both together were genetically deleted. In resting cells of the double mutant, hydrogen formation from fructose was completely abolished and carbon was redirected largely to ...
Source: Applied Microbiology and Biotechnology - July 7, 2023 Category: Microbiology Authors: Jimyung Moon Lara M Waschinger Volker M üller Source Type: research
Mirabegron alleviates acetic acid-induced colitis in rats: role of adiponectin and GSTM1/GSH detoxification pathway
In conclusion, mirabegron prevented acetic acid-induced colitis in rats, possibly due to its antioxidant, anti-inflammatory, and antiapoptotic properties.PMID:37414241 | DOI:10.1016/j.tox.2023.153586
Source: Toxicology - July 6, 2023 Category: Toxicology Authors: Mervat Z Mohamed Mohamed F Abed El Baky Sahar A Mokhemer Heba M Hafez Source Type: research
