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Total 1984 results found since Jan 2013.
Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
AbstractNeurological manifestations of coronavirus disease 2019 (COVID-19) are less noticeable than the respiratory symptoms, but they may be associated with disability and mortality in COVID-19. Even though Omicron caused less severe disease than Delta, the incidence of neurological manifestations is similar. More than 30% of patients experienced “brain fog”, delirium, stroke, and cognitive impairment, and over half of these patients presented abnormal neuroimaging outcomes. In this review, we summarize current advances in the clinical findings of neurological manifestations in COVID-19 patients and compare them with ...
Source: Neuroscience Bulletin - September 16, 2023 Category: Neuroscience Source Type: research
Bioinformatics analysis of carotid vulnerable plaques associated with the SARS-CoV-2 Pattern
Gene. 2023 Aug 31:147754. doi: 10.1016/j.gene.2023.147754. Online ahead of print.ABSTRACTThe rupture of carotid artery vulnerable plaque plays a critical role in ischemic stroke, and the widely spread new coronavirus in recent years plays a certain role in the development of human carotid artery vulnerable plaque, we screened out 27 differential expression genes (DEGs) of stable plaque and vulnerable plaque associated with the new coronavirus. Through the construction of the protein-protein interaction (PPI) network, the Cathepsin B (CTSB) and Niemann-Pick Disease Type 2 (NPC2) were identified as crucial expression genes, ...
Source: Gene - September 2, 2023 Category: Genetics & Stem Cells Authors: Tao Jiang Jiaming Huang Shupeng Li Qiushi Xu Tianding Zhang Xianwei Wang Dong Chen Source Type: research
Neurological manifestations of SARS-CoV-2: complexity, mechanism and associated disorders
CONCLUSIONS: SARS-CoV-2 can lead to neurological complications, such as cerebrovascular manifestations, motor movement complications, and cognitive decline. COVID-19 infection can result in cerebrovascular symptoms and diseases, such as strokes and thrombosis. The virus can affect the neural system, disrupt cognitive function and cause neurological disorders. To combat the epidemic, it is crucial to repurpose drugs currently in use quickly and develop novel therapeutics.PMID:37649125 | PMC:PMC10469568 | DOI:10.1186/s40001-023-01293-2
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Kritika Tyagi Prachi Rai Anuj Gautam Harjeet Kaur Sumeet Kapoor Ashish Suttee Pradeep Kumar Jaiswal Akanksha Sharma Gurpal Singh Ravi Pratap Barnwal Source Type: research
Single-cell RNA sequencing and multiple bioinformatics methods to identify the immunity and ferroptosis related biomarkers of SARS-CoV-2 infections to ischemic stroke
CONCLUSION: We believe these genes (B4GALT5, CRISPLD2, F5, ACSL1, CREB5) may regulate the immune response and ferroptosis of multiple immune cells, mainly including monocytes, which may contribute to the development of COVID-19-related IS. In addition, these genes may be potential targets for the treatment of COVID-19-related IS.PMID:37606960 | DOI:10.18632/aging.204966
Source: Aging - August 22, 2023 Category: Biomedical Science Authors: Xiang Zhao Qingyu Liang Hao Li Zhitao Jing Dongmei Pei Source Type: research
The influence of COVID-19 on the treatment of patients with acute ischemic stroke: a retrospective observational study
CONCLUSIONS: The pandemic situation of COVID-19 significantly reduced the number of patients with AIS and prolonged the travel time to the hospital whereas most of the stroke treatment services were maintained.PMID:37587891 | DOI:10.5114/fn.2023.124565
Source: Folia Neuropathologica - August 17, 2023 Category: Neurology Authors: Wei Chen Fangju Lin Wei Zhao Baoling Yang Weihua Jia Source Type: research
