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A narrative review on the application of high-intensity focused ultrasound for the treatment of occlusive and thrombotic arterial disease
CONCLUSIONS: In current preclinical and clinical data, the safety and efficacy of HIFU shows great promise in the treatment of atherosclerotic arterial disease. Future focused studies are warranted to guide the refinement of HIFU settings for more widespread adoption of this technology.PMID:36276806 | PMC:PMC9579503 | DOI:10.1016/j.jvssci.2022.08.001
Source: Atherosclerosis - October 24, 2022 Category: Cardiology Authors: Anand Brahmandam Shin Mei Chan Alan Dardik Naiem Nassiri Edouard Aboian Source Type: research

Effect of intravenous HDL- loaded microbubbles administration on ultrasound- guided pulsed- high intensity focused ultrasound- mediated histotripsy of carotid artery advanced atherosclerotic plaque
In this study, we developed an experimental pulsed- high intensity focused ultrasound (750 KHz, 40 W/Cm2 , 38 Hz), and investigated its effectiveness on advanced atherosclerotic plaque regression, wherein diagnostic B- mode ultrasound is combined with focused ultrasound, with a goal of increased safety.
Source: Atherosclerosis - August 1, 2018 Category: Cardiology Authors: H. Mehrad, M. Farhoudi, L. Zeinalizad, F. Masoumi, S. Pourhaji Aga Golestani, A. Najafzadeh Source Type: research

High-intensity focused ultrasound: past, present, and future in neurosurgery.
Abstract Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for intracranial ablation in 1942, many strides have been made toward the treatment of several brain pathologies using this novel technology. In the modern era of minimal invasiveness, high-intensity focused ultrasound (HIFU) promises therapeutic utility for multiple neurosurgical applications, including treatment of tumors, stroke, epilepsy, and functional disorders. Although the use of HIFU as a potential therapeutic modality in the brain has been under study for several decades, relatively few neuroscientists, neurologi...
Source: Neurosurgical Focus - February 1, 2018 Category: Neurosurgery Authors: Quadri SA, Waqas M, Khan I, Khan MA, Suriya SS, Farooqui M, Fiani B Tags: Neurosurg Focus Source Type: research

Magnetic resonance-guided, high-intensity focused ultrasound sonolysis: potential applications for stroke.
Abstract Stroke is one of the leading causes of death worldwide and a significant source of long-term morbidity. Unfortunately, a substantial number of stroke patients either are ineligible or do not significantly benefit from contemporary medical and interventional therapies. To address this void, investigators recently made technological advances to render transcranial MR-guided, high-intensity focused ultrasound (MRg-HIFU) sonolysis a potential therapeutic option for both acute ischemic stroke (AIS)-as an alternative for patients with emergent large-vessel occlusion (ELVO) who are ineligible for endovascular me...
Source: Neurosurgical Focus - February 1, 2018 Category: Neurosurgery Authors: Ilyas A, Chen CJ, Ding D, Romeo A, Buell TJ, Wang TR, Kalani MYS, Park MS Tags: Neurosurg Focus Source Type: research

Validation of an intracardiac ultrasonic therapy –imaging dual mode transducer
In this study we have developed a novel dual-mode intracardiac echocardiography catheter capable of performing ultrasound imaging and high-intensity focused ultrasound ablation. Using the same device we demonstrate in vivo the feasibility of intracardiac shear-wave elastography to evaluate thermal ablation as well as the feasibility of creating transmural and linear lesions (up to 10-mm wide) in the atrial wall.
Source: IRBM - July 20, 2016 Category: Biomedical Engineering Source Type: research

Thrombolysis using multi-frequency high intensity focused ultrasound at MHz range: an in vitro study.
In this study, multi-frequency acoustic waves at MHz range (near 1.5 MHz) were introduced as HIFU excitations to reduce the required power for treatment as well as the treatment time. In vitro bovine blood clots weighing around 150 mg were treated by single-frequency and multi-frequency HIFU. The pulse length was 2 ms for all experiments except the ones where the duty cycle was changed. It was found that dual-frequency thrombolysis efficiency was statistically better than single-frequency under the same acoustic power and excitation condition. When varying the acoustic power but fixing the duty cycle at 5%, it was foun...
Source: Physica Medica - September 9, 2015 Category: Physics Authors: Suo D, Guo S, Lin W, Jiang X, Jing Y Tags: Phys Med Biol Source Type: research

Validation of an intracardiac ultrasonic therapy–imaging dual mode transducer
In this study we have developed a novel dual-mode intracardiac echocardiography catheter capable of performing ultrasound imaging and high-intensity focused ultrasound ablation. Using the same device we demonstrate in vivo the feasibility of intracardiac shear-wave elastography to evaluate thermal ablation as well as the feasibility of creating transmural and linear lesions (up to 10-mm wide) in the atrial wall.
Source: IRBM - May 30, 2015 Category: Biomedical Engineering Source Type: research

High-Intensity Focused Ultrasound Sonothrombolysis: The Use of Perfluorocarbon Droplets to Achieve Clot Lysis at Reduced Acoustic Power
The purpose of this study was to evaluate use of intravascular perfluorocarbon droplets to reduce the sonication power required to achieve clot lysis with high-intensity focused ultrasound. High-intensity focused ultrasound with droplets was initially applied to blood clots in an in vitro flow apparatus, and inertial cavitation thresholds were determined. An embolic model for ischemic stroke was used to illustrate the feasibility of this technique in vivo. Recanalization with intravascular droplets was achieved in vivo at 24 ± 5% of the sonication power without droplets.
Source: Ultrasound in Medicine and Biology - July 9, 2014 Category: Radiology Authors: Daniel Pajek, Alison Burgess, Yuexi Huang, Kullervo Hynynen Tags: Original Contributions Source Type: research