A Comparison of ECG Signal Pre-Processing Using FrFT, FrWT and IPCA for Improved Analysis
ConclusionCorrect analysis of the acquired ECG signal is the main challenge for cardiologist due to involvement of various types of noises (high and low frequency). Twenty two real time ECG records have been evaluated based on various FoM such as SNR, Se, Acc and DER for the proposed FrWT and existing FrFT and IPCA preprocessing techniques. Acquired real-time ECG database in normal and disease situations is used for the purpose. The values of FoMs indicate high SNR and better detection of R-peaks in a ECG signal which is important for the diagnosis of cardiovascular disease. The proposed FrWT outperforms all other techniqu...
Source: IRBM - April 18, 2019 Category: Biomedical Engineering Source Type: research

State of the Art Technology for Bone Tissue Engineering and Drug Delivery
ConclusionThe biodegradable beads used as a local drug delivery system are ubiquitous in surgery to treat post-operative infections but does not play any role in tissue regeneration. The use of this clinically accepted drug delivery technique in bone regeneration is an alternative way for the treatment on several bone infections (especially osteomyelitis and arthritis associated with tuberculosis). It is predicted to be the future of organ replacement and treatment.Graphical abstract (Source: IRBM)
Source: IRBM - March 20, 2019 Category: Biomedical Engineering Source Type: research

Editorial Board
Publication date: March 2019Source: IRBM, Volume 40, Issue 2Author(s): (Source: IRBM)
Source: IRBM - March 14, 2019 Category: Biomedical Engineering Source Type: research

A New Method for Nonlinear Dynamic Analysis of the Multi-kinetics Neural Mass Model
ConclusionThe Lorenz plot of EEG signals with different rhythms presents different distribution. It is an effective nonlinear analysis method for EEG signals.Graphical abstract (Source: IRBM)
Source: IRBM - March 8, 2019 Category: Biomedical Engineering Source Type: research

Eigenspace Time Frequency Based Features for Accurate Seizure Detection from EEG Data
ConclusionExperimental results show that the novel features have successfully represented the characteristics of the underlying disease phenomenon from EEG data. Also, we conclude that learning based classifiers are better suited for this application, compared to Bayesian classifiers that have difficulty in adapting to the varying nature of the features' probability distribution function.Graphical abstract (Source: IRBM)
Source: IRBM - March 4, 2019 Category: Biomedical Engineering Source Type: research

Hybrid Nature Inspired SMO-GBM Classifier for Exudate Classification on Fundus Retinal Images
Conclusion: The proposed approach provides detection and grading of diabetic retinopathy. The abnormality is further categories as soft, moderate and severe. The hybrid SMO-GBM classifier yields a better statistical metrics than the existing exudates classification approaches.Graphical abstract (Source: IRBM)
Source: IRBM - February 26, 2019 Category: Biomedical Engineering Source Type: research

Registration Error and Intensity Similarity Based Label Fusion for Segmentation
ConclusionsTaking the registration quality, the inter-atlas correlations and intensity differences into account in label fusion benefits to improve the object segmentation accuracy and robustness.Graphical abstract (Source: IRBM)
Source: IRBM - February 19, 2019 Category: Biomedical Engineering Source Type: research

Identification of the Pain Process by Cold Stimulation: Using Dynamic Causal Modeling of Effective Connectivity in Functional Near-Infrared Spectroscopy (fNIRS)
ConclusionThis study contributes to the pain research field to identify the directionality and causality of neuronal connections in the prefrontal cortex by applying DCM to fNIRS data. The results suggest that the proposed method infers directional interactions between hidden neuronal states in the brain under neuronal dynamic conditions based on optical density changes measurement.Graphical abstract (Source: IRBM)
Source: IRBM - January 26, 2019 Category: Biomedical Engineering Source Type: research

Editorial Board
Publication date: February 2019Source: IRBM, Volume 40, Issue 1Author(s): (Source: IRBM)
Source: IRBM - January 26, 2019 Category: Biomedical Engineering Source Type: research

IRBM Focus on Biomedical Ultrasound
Publication date: February 2019Source: IRBM, Volume 40, Issue 1Author(s): D. Melodelima, F. Frouin (Source: IRBM)
Source: IRBM - January 26, 2019 Category: Biomedical Engineering Source Type: research

Detection of Seizure Event and Its Onset/Offset Using Orthonormal Triadic Wavelet Based Features
ConclusionThe present study focuses on detection of seizure onset and offset rather than only seizure detection. The major contribution of this work is that the novel triadic wavelet transform based method is developed for the analysis of EEG signals. The results show improvement over other existing dyadic wavelet based Triadic techniques.Graphical abstract (Source: IRBM)
Source: IRBM - December 28, 2018 Category: Biomedical Engineering Source Type: research

Comparison of Several Algorithms to Estimate Activity Counts with Smartphones as an Indication of Physical Activity Level
Publication date: Available online 18 December 2018Source: IRBMAuthor(s): V.H. Rodriguez, C. Medrano, I. Plaza, C. Corella, A. Abarca, J.A. JulianAbstractBackgroundDedicated devices like GT3X+, Actical or ActivPal have been widely used to measure physical activity (PA) levels by using cut-points on activity counts. However, the calculation of activity counts relies on proprietary software. Since smartphones incorporate accelerometers they are suitable candidates to determine PA levels in a wider population.ObjectiveOur aim was to compare several algorithms so that smartphones can reproduce the results obtained with GT3X+. ...
Source: IRBM - December 19, 2018 Category: Biomedical Engineering Source Type: research

Effect of the Photodynamic Therapy Applications with Potent Microalgae Constituents on Several Types of Tumor
ConclusionThe results clearly showed that MA constituents are potential photosensitizers that have a significant photo-damage effects on the tested cancer cells.Graphical abstract (Source: IRBM)
Source: IRBM - December 14, 2018 Category: Biomedical Engineering Source Type: research

EEG and cognitive biomarkers based mild cognitive impairment diagnosis
ConclusionsOur classifier findings are consistent with the utmost evidence. Yet, our results are promising and especially newfangled in the case of FTT and CPT from the prior studies. We developed an experimental protocol and proposed a novel technique to classify MCI with efficient biomarkers.Graphical abstract (Source: IRBM)
Source: IRBM - December 5, 2018 Category: Biomedical Engineering Source Type: research

Ultrasound-Targeted Microbubble Destruction (UTMD) for Localized Drug Delivery into Tumor Tissue
Publication date: Available online 28 November 2018Source: IRBMAuthor(s): J. Wischhusen, F. PadillaAbstractBackgroundUltrasound-targeted microbubble destruction (UTMD) is a type of ultrasound therapy, in which low frequency moderate power ultrasound is combined with microbubbles to trigger cavitation. Cavitation is the process of oscillation of gas bubbles causing biophysical effects such as pushing and pulling or shock waves that permeabilize biological barriers. In vivo, cavitation results in tissue permeabilization and is used to enable local delivery of nanomedicine. While cavitation can occur in biological liquids whe...
Source: IRBM - November 28, 2018 Category: Biomedical Engineering Source Type: research

Quantitative Ultrasound Assessment of Cortical Bone Properties Beyond Bone Mineral Density
This article aims at an overview of recent QUS developments to measure cortical bone properties. We also draw a picture of the current knowledge on bone material properties of interest for bone QUS. We discuss the potential of ultrasound to provide novel biomarkers of bone health through the assessment of material properties.Graphical abstract (Source: IRBM)
Source: IRBM - November 23, 2018 Category: Biomedical Engineering Source Type: research

An Improved SSA-Based Technique for EMG Removal From ECG
ConclusionThe experimental results demonstrate effectiveness of the proposed method in comparison with other SSA-based techniques.Graphical abstract (Source: IRBM)
Source: IRBM - November 23, 2018 Category: Biomedical Engineering Source Type: research

Editorial Board
Publication date: December 2018Source: IRBM, Volume 39, Issue 6Author(s): (Source: IRBM)
Source: IRBM - November 23, 2018 Category: Biomedical Engineering Source Type: research

JETSAN: A Reference Workshop of E-Health in France
Publication date: December 2018Source: IRBM, Volume 39, Issue 6Author(s): D. Istrate, F. Frouin (Source: IRBM)
Source: IRBM - November 23, 2018 Category: Biomedical Engineering Source Type: research

Photoacoustic Monitoring of the Viability of Mesenchymal Stem Cells Labeled With Indocyanine Green
ConclusionThe experimental results imply the feasibility of noninvasive detection of stem cell viability during therapeutic procedures.Graphical abstract (Source: IRBM)
Source: IRBM - November 16, 2018 Category: Biomedical Engineering Source Type: research

Activity Recognition for Anomalous Situations Detection
ConclusionOur method allows, on one hand, recognizing user activities and, on the other hand, detecting eventual occurrence of anomalies in the user's situation. It proves to be efficient using the tested datasets for each module. However, in order to obtain a more general conclusion we plan to evaluate the method using more different datasets.Graphical abstract (Source: IRBM)
Source: IRBM - November 11, 2018 Category: Biomedical Engineering Source Type: research

Editorial Board
Publication date: November 2018Source: IRBM, Volume 39, Issue 5Author(s): (Source: IRBM)
Source: IRBM - November 3, 2018 Category: Biomedical Engineering Source Type: research

Preliminary Investigation of a 64-element Capacitive Micromachined Ultrasound Transducer (CMUT) Annular Array Designed for High Intensity Focused Ultrasound (HIFU)
ConclusionThis work demonstrates the feasibility of utilizing a planar CMUT probe for generating dynamic HIFU focusing and lesioning compatible with the ablation of prostate tissues under endocavitary treatment approach. Future investigations will consist of validating the lesioning capability experimentally both in vitro and in vivo.Graphical abstract (Source: IRBM)
Source: IRBM - October 27, 2018 Category: Biomedical Engineering Source Type: research

Plas'O'Soins: An Interactive ICT Platform to Support Care Planning and Coordination within Home-Based Care
ConclusionThe software platform has been deployed and used in an experimental setting by homecare partner organizations, providing valuable insights on the organizational changes required by the introduction of such an ICT solution in the actual practice of homecare.Graphical abstract (Source: IRBM)
Source: IRBM - October 26, 2018 Category: Biomedical Engineering Source Type: research

ReSynPlex: Respiratory Syndrome Linked Pathogens Multiplex Detection and Characterization
ConclusionThe HIFI Resp product based on a sample-to-result syndromic approach, with a minimum user intervention during the procedure on a cost efficient automated platform and a short time of analysis is a promising device.Graphical abstract (Source: IRBM)
Source: IRBM - October 24, 2018 Category: Biomedical Engineering Source Type: research

Ultrasound Molecular Imaging with Targeted Microbubbles for Cancer Diagnostics: From Bench to Bedside
Publication date: Available online 23 October 2018Source: IRBMAuthor(s): J. Wischhusen, F. PadillaAbstractBackgroundUltrasound plays an important role in cancer diagnosis. B-mode imaging and contrast-enhanced ultrasound are routinely used to detect cancerous lesions in breast and liver. The use of ultrasound contrast agents (UCAs) such as microbubbles (MBs), which can be functionalized with targeting ligands, has further enabled ultrasound molecular imaging (USMI) of specific molecular markers in pre-clinical and the first clinical studies. As targeted MBs have a diameter of 1–4 μm, they are limited to the blood v...
Source: IRBM - October 24, 2018 Category: Biomedical Engineering Source Type: research

Two-Stage Feature Selection of Voice Parameters for Early Alzheimer's Disease Prediction
ConclusionThe proposed method improved the classification accuracy for ES-AD, MCI and HC groups and promises the effectiveness of speech analysis and machine learning techniques to help detect pathological diseases.Graphical abstract (Source: IRBM)
Source: IRBM - October 24, 2018 Category: Biomedical Engineering Source Type: research

Microwave Resonant Sensor for Non-invasive Characterization of Biological Tissues
ConclusionsThis paper presents an improved microwave sensor, either for reduced dimensions as for sensitivity, able to perform dielectric characterization of material having high complex permittivity such as biological tissues. Experiments and electromagnetic simulations have been achieved on several animal tissues (chicken, beef, pork …), and results are in good agreement with literature. Works are in progress to optimize this sensor as an applicator for medical applications.Graphical abstract (Source: IRBM)
Source: IRBM - October 24, 2018 Category: Biomedical Engineering Source Type: research

Detection of Movement Artefacts and Contraction Bursts Using Accelerometer and Electrohysterograms for Home Monitoring of Pregnancy
In this study, we investigated the detectability of a begin/end of contraction by analyzing EHG signals with the Bayes Information Criterion, and we analyzed the three axis accelerometer signals to characterize the mother activity when she is carrying the device (such movements being possible sources of artifacts in the EHG signals).ResultsFor the contraction detections, we obtained 68.38% (599/876) of good detection but a too high number of false alarms (1073). To reduce this false alarm number, we analyzed the three accelerometer signals and detected 98.7% of static phases of the mother and 95% of dynamic ones.Discussion...
Source: IRBM - October 23, 2018 Category: Biomedical Engineering Source Type: research

Serious Games for Home Based Rehabilitation: Inertial Sensor Energy Consumption
ConclusionFinally, these results allowed us to establish an optimal set up configuration for home based rehabilitation using serious games.Graphical abstract (Source: IRBM)
Source: IRBM - October 23, 2018 Category: Biomedical Engineering Source Type: research

Ergonomic Risk Assessment of Developing Musculoskeletal Disorders in Workers with the Microsoft Kinect: TRACK TMS
ConclusionLow-cost three-dimensional cameras can be a useful aid in ergonomic risk assessment of developing musculoskeletal disorders and give the example of the repetition of movements and postural items included in the OCRA checklist, whose scoring can be facilitated by such a device.Graphical abstract (Source: IRBM)
Source: IRBM - October 20, 2018 Category: Biomedical Engineering Source Type: research

A Framework for Service Robots in Smart Home: An Efficient Solution for Domestic Healthcare
ConclusionOur framework provides software tools that make robots and smart environments more relevant in real housings. By supporting the uncertainty of context data and the dynamism of the environment, robots and smart environments can achieve more effectively their purposes in domestic healthcare applications.Graphical abstract (Source: IRBM)
Source: IRBM - October 20, 2018 Category: Biomedical Engineering Source Type: research

Home-Based Adapted Physical Activity by Means of a Motivational Aide Solution
The objective of the Motiv@Dom project is to create motivational and enjoyable solutions to help seniors to practice an adapted OR appropriate physical activity at home. Faithful to the Living Lab approach, this project has adopted a user-centered and participative strategy. The users are involved throughout the design process of the Motiv@Dom solution, from the first ideas to the evaluation of the final product. In fact, we do our designing not only by placing the user at the center of our work, but above all “with the seniors” and “for the seniors”, giving them a role just as important as the othe...
Source: IRBM - October 20, 2018 Category: Biomedical Engineering Source Type: research

Laser-Generated Au Nanoparticles for Bio-Medical Applications
ConclusionsThe aim of this research is to transport the nanoparticles in places where tissue disease exists and reduce their concentration in healthy tissues. This permit a better observation of the diseased tissues and their preparation as targeting for radio- and thermal-therapy to be applied to damage tumor cells saving healthy tissues.Graphical abstract (Source: IRBM)
Source: IRBM - October 20, 2018 Category: Biomedical Engineering Source Type: research

Feasibility Study of the Elaboration of a Biodegradable and Bioactive Ligament Made of Poly(ε-caprolactone)-pNaSS Grafted Fibers for the Reconstruction of Anterior Cruciate Ligament: In Vivo Experiment
ConclusionThis work demonstrates the feasibility to implant a bioactive and biodegradable synthetic ligament in the rat model without any inflammation and with a good tissue anchoring at a short-term time. This will lead to an extensive in vivo assay.Graphical abstract (Source: IRBM)
Source: IRBM - October 20, 2018 Category: Biomedical Engineering Source Type: research

Automated Classification of Fatty and Normal Liver Ultrasound Images Based on Mutual Information Feature Selection
ConclusionThe experimental results show that the proposed system can be used for the classification of fatty and normal liver ultrasound images with higher accuracy.Graphical abstract (Source: IRBM)
Source: IRBM - October 20, 2018 Category: Biomedical Engineering Source Type: research

Semi-global Parameterization of Online Handwriting Features for Characterizing Early-Stage Alzheimer and Mild Cognitive Impairment
ConclusionA semi-global parametrization of handwriting spatiotemporal parameters allows for a better discrimination between the HC, MCI and ES-AD profiles, than a global one does. Unlike the latter, the former encodes the distribution of the dynamics of each parameter, which offers a larger parameter space in which discrimination is easier.Graphical abstract (Source: IRBM)
Source: IRBM - October 18, 2018 Category: Biomedical Engineering Source Type: research

Swallowing Sound Recognition at Home Using GMM
ConclusionThe proposal method has great potential to assist in the clinical evaluation using only swallowing sounds, which is a non-invasive technic for swallowing studies.Graphical abstract (Source: IRBM)
Source: IRBM - October 18, 2018 Category: Biomedical Engineering Source Type: research

AidAdom: Supporting Inter-Organizational Coordination for Home Help and Healthcare Services Through a Web Platform
ConclusionThe AidAdom platform provides a lightweight system which enables organizations to share a minimal set of coordination information. Our future work is oriented toward opening the system to new help and healthcare service professionals and organizations.Graphical abstract (Source: IRBM)
Source: IRBM - October 18, 2018 Category: Biomedical Engineering Source Type: research

Precise Cobb Angle Measurement System Based on Spinal Images Merging Function
ConclusionThe developed measurement system demonstrated its measurement performance accurately and practically.Graphical abstract (Source: IRBM)
Source: IRBM - October 14, 2018 Category: Biomedical Engineering Source Type: research

Computerised Decision Support System for Remote Health Monitoring: A Systematic Review
ConclusionThe proposed system includes the model that provides the correlations of several biosignals like electrocardiogram (ECG), peripheral capillary oxygen saturation (SPO2), body temperature and heartbeat, thereby identifying the critical situations and making the decisions using CDSS that helps in taking the necessary clinical interventions.Graphical abstract (Source: IRBM)
Source: IRBM - October 12, 2018 Category: Biomedical Engineering Source Type: research

Early Stage Chronic Kidney Disease Diagnosis by Applying Data Mining Methods to Urinalysis, Blood Analysis and Disease History
ConclusionA new automatic early stage CKD diagnosis method was proposed to help the medical doctors. Attributes that would provide the highest diagnosis success rate were the use of specific gravity, albumin, sugar and red blood cells together. Also, the relation between the success rate of automatic diagnosis method and age was identified.Graphical abstract (Source: IRBM)
Source: IRBM - October 11, 2018 Category: Biomedical Engineering Source Type: research

Eight Weeks of Local Vibration Training Do Not Increase Tibialis Anterior Muscle Stiffness Evaluated by Supersonic Shear Imaging
ConclusionOur results suggest that adaptations in elastic muscle properties do not explain the increased muscle strength reported after LV training.Graphical abstract (Source: IRBM)
Source: IRBM - October 5, 2018 Category: Biomedical Engineering Source Type: research

An Optimized Cascaded Stochastic Resonance for the Enhancement of Brain MRI
ConclusionThe cascaded DSR based on MOPSO has shown promising results and may be highly beneficial to the diagnosis of different brain pathology.Graphical abstract (Source: IRBM)
Source: IRBM - September 19, 2018 Category: Biomedical Engineering Source Type: research

Analysis of User Control Attainment in SMR-based Brain Computer Interfaces
ConclusionsThe study concludes that the slow control attainment in SMR-based BCIs is due to its reliance on user training (neural adaptation) which is adaptive but too slow in the context of SMR modulations and due to the weak decoding of the neuronal phenomenon utilised by the user. As a recommendation, the optimality of the feature selection algorithm could be looked at to guarantee the use of the most relevant features. However and most importantly the predictive power of the translation model should be significantly improved in order to quicken control attainment as thereafter the control attainment effort could be shi...
Source: IRBM - September 18, 2018 Category: Biomedical Engineering Source Type: research

Editorial Board
Publication date: August 2018Source: IRBM, Volume 39, Issue 4Author(s): (Source: IRBM)
Source: IRBM - August 1, 2018 Category: Biomedical Engineering Source Type: research

Notch Pathway: Bioinformatic Analysis of Related Transcription Factors within Bladder Cancer Types and Subtypes
ConclusionNotch signaling pathway regulators do not have the same activity within the different subtypes of bladder cancer and they can be divided into two groups that behave inversely. We showed for the first time that NOTCH3 does not have the same activity within bladder cancer categories and subtypes.Graphical abstract (Source: IRBM)
Source: IRBM - July 21, 2018 Category: Biomedical Engineering Source Type: research

A Simple Method to Functionalize PCL Surface by Grafting Bioactive Polymers Using UV Irradiation
ConclusionWe developed a new approach of radical grafting which allows us to successfully graft bioactive polymer polyNaSS covalently to PCL surfaces using UV irradiation.Graphical abstract (Source: IRBM)
Source: IRBM - July 21, 2018 Category: Biomedical Engineering Source Type: research

Therapeutic Ultrasound for the Heart: State of the Art
Publication date: Available online 2 December 2017Source: IRBMAuthor(s): P. Greillier, C. Bawiec, F. Bessière, C. LafonAbstractThis work describes the use of therapeutic ultrasound as a treatment of cardiovascular disease including recent, state of the art approaches. Therapeutic ultrasound researchers have made recent advances in the highly dynamic and changing world of interventional cardiology where they are confronted with several challenges, such as of the complexity of ultrasound propagation in the highly heterogeneous environment of the thorax or the complexity of the heart (in term of motion and physiology)....
Source: IRBM - July 10, 2018 Category: Biomedical Engineering Source Type: research

Shear-Wave Sources for Soft Tissues in Ultrasound Elastography
Publication date: Available online 1 February 2018Source: IRBMAuthor(s): B. Giammarinaro, A. Zorgani, S. CathelineAbstractElastography is an imaging tool for soft-tissue characterization in the human body, and it is based on the propagation of shear waves. Since its first use in the ultrasound landscape, the generation of shear waves has had practical and theoretical issues. In this review, the use of four methods of shear-wave generation are considered: an external vibrating source; a radiation pressure source; a natural source; and an electromagnetic source. The pros and cons of these methods are detailed and discussed. (Source: IRBM)
Source: IRBM - July 10, 2018 Category: Biomedical Engineering Source Type: research