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Procedure: Transplants
Therapy: Stem Cell Therapy
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Total 1021 results found since Jan 2013.
Coating-Free Culture Medium for Establishing and Maintaining Human Induced Pluripotent Stem Cells
In this study, we develop an innovative coating-free medium for expanding hPSCs. The xenofree medium supports the weekend-free culture and competitive growth of hPSCs on several cell culture plastics without an additional pre-coating process. The pluripotent stemness of the expanded cells is stably sustained for more than 10 passages, featured with high pluripotent marker expressions, normal karyotyping, and differentiating capacity for three germ layers. The expression levels of some integrins are reduced, compared with those of the hPSCs on Matrigel. This medium also successfully supports the clonal expansion and induced...
Source: Cell Transplantation - September 12, 2023 Category: Cytology Authors: Chih-Yao Lin Yu-Yun Ching Shih-Fang Wu Yi-Ko Lee Hueng-Chuen Fan Liang-Yu Su Su-Yi Tsai Yu-Ching Chen Ching-I Shen Hong-Lin Su Source Type: research
MCPIP-1 knockdown enhances endothelial colony-forming cell angiogenesis via the TFRC/AKT/mTOR signaling pathway in the ischemic penumbra of MCAO mice
In this study, we performed Proteome Profiler™ Human Angiogenesis Antibody arrays and tandem mass tag protein profiling to investigate the effect of MCPIP-1 on ECFCs. We demonstrated that MCPIP-1 knockdown enhanced the proliferation, migration, and in vivo and in vitro angiogenic capacity of ECFCs by upregulating the transferrin receptor-activated AKT/m-TOR signaling pathway to promote cellular trophic factor secretion. Furthermore, we found that the lateral ventricular transplantation of ECFCs with lentiviral MCPIP-1 knockdown into mice with middle cerebral artery occlusion increased serum vacular endothelial growth fac...
Source: Experimental Neurology - September 9, 2023 Category: Neurology Authors: Xiaoxiong Zou Yu Xie Zhongfei Zhang Zhiming Feng Jianbang Han Qian Ouyang Shiting Hua Sixian Huang Cong Li Zhizheng Liu Yingqian Cai Yuxi Zou Yanping Tang Haijia Chen Xiaodan Jiang Source Type: research
Comparative Analysis of the Results of Stroke Treatment With Multiple Administrations of Wharton's Jelly Mesenchymal Stem Cells-Derived HE-ATMP and Standard Conservative Treatment: Case Series Study
Cell Transplant. 2023 Jan-Dec;32:9636897231195145. doi: 10.1177/09636897231195145.ABSTRACTStroke remains still the leading cause of long-term disability worldwide. Although interventions such as early reperfusion, intravenous thrombolysis, and endovascular revascularization have shown neurological benefit in stroke patients, there is still lack of effective treatment enabling regeneration of nervous tissue after cerebral ischemic episodes. Cell therapy is an evolving opportunity for stroke survivors with residual neurological deficits. The purpose of this study was to evaluate safety and potential efficacy of multiple admi...
Source: Cell Transplantation - August 30, 2023 Category: Cytology Authors: Olga Milczarek Jakub Swad źba Patrycja Swad źba Anna Starowicz-Filip Roger M Krzy żewski Stanis ław Kwiatkowski Marcin Majka Source Type: research
Efficacy and Safety of Bone Marrow Derived Stem Cell Therapy for Ischemic Stroke: Evidence from Network Meta-analysis
CONCLUSION: Using stem cell transplantation was associated with reduced risk of death and improved functional outcomes in patients with ischemic stroke. Additional large trials are warranted to provide more conclusive evidence.PMID:37612871 | DOI:10.2174/1574888X18666230823094531
Source: Current Stem Cell Research and Therapy - August 24, 2023 Category: Stem Cells Authors: Xing Wang Jingguo Yang Chao You Xinjie Bao Lu Ma Source Type: research
Human umbilical cord derived mesenchymal stem cells overexpressing HO-1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice
CONCLUSION: The findings indicate that MSCs overexpressing HO-1 exhibited significant therapeutic effects against hyper-inflammatory injury after stroke in mice, ultimately promoting recovery after ischemic stroke.PMID:37592866 | DOI:10.1111/cns.14412
Source: CNS Neuroscience and Therapeutics - August 18, 2023 Category: Neuroscience Authors: Yu Yang Qianqian Liu Song Deng Qian Shao Long Peng Yuejuan Ling Yue Huang Siqi Zheng Qiaoji Jiang Dekang Nie Jian Chen Source Type: research
Deficiency of Adenosine Deaminase 2
Deficiency of adenosine deaminase 2 (DADA2) is a monogenic vasculitis syndrome caused by biallelic mutations in the adenosine deaminase 2 gene. The diagnosis of DADA2 is confirmed by decreased enzymatic activity of ADA2 and genetic testing. Symptoms range from cutaneous vasculitis and polyarteritis nodosa-like lesions to stroke. The vasculopathy of DADA2 can affect many organ systems, including the gastrointestinal and renal systems. Hematologic manifestations occur early with hypogammaglobulinemia, lymphopenia, pure red cell aplasia, or pancytopenia. Treatment can be challenging. Tumor necrosis factor inhibitors are helpf...
Source: Rheumatic Disease Clinics of North America - August 1, 2023 Category: Rheumatology Authors: Andrew Grim, Keila R. Veiga, Nadine Saad Source Type: research
Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review
Cell Transplant. 2023 Jan-Dec;32:9636897231184596. doi: 10.1177/09636897231184596.ABSTRACTThe immense neuroinflammation induced by multiple sclerosis (MS) promotes a favorable environment for ischemic stroke (IS) development, making IS a deadly complication of MS. The overlapping inflammation in MS and IS is a prelude to the vascular pathology, and an inherent cell death mechanism that exacerbates neurovascular unit (NVU) impairment in the disease progression. Despite this consequence, no therapies focus on reducing IS incidence in patients with MS. To this end, the preclinical and clinical evidence we review here argues f...
Source: Cell Transplantation - July 29, 2023 Category: Cytology Authors: Molly Monsour Jonah Gordon Gavin Lockard Cesar V Borlongan Source Type: research
