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Specialty: Neuroscience
Therapy: Stem Cell Therapy

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Total 104 results found since Jan 2013.

Is forebrain neurogenesis a potential repair mechanism after stroke?
Is forebrain neurogenesis a potential repair mechanism after stroke? Journal of Cerebral Blood Flow & Metabolism 35, 1220 (July 2015). doi:10.1038/jcbfm.2015.95 Authors: Dragos Inta & Peter Gass
Source: Journal of Cerebral Blood Flow and Metabolism - June 30, 2015 Category: Neuroscience Authors: Dragos IntaPeter Gass Tags: acute stroke animal models brain recovery neural stem cells neuroregeneration Source Type: research

Sex differences in stroke therapies
Stroke is the fifth leading cause of death and acquired disability in aged populations. Women are disproportionally affected by stroke, having a higher incidence and worse outcomes than men. Numerous preclinical studies have discovered novel therapies for the treatment of stroke, but almost all of these have been shown to be unsuccessful in clinical trials. Despite known sex differences in occurrence and severity of stroke, few preclinical or clinical therapeutics take into account possible sex differences in treatment. Reanalysis of data from studies of tissue plasminogen activator (tPA), the only currently FDA‐approved...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Farida Sohrabji, Min Jung Park, Amanda H. Mahnke Tags: Review Source Type: research

Gender-Linked Stem Cell Alterations in Stroke and Postpartum Depression.
Abstract Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a comorbidity factor of stroke, plays a key role in regenerative medicine, in particular stem cell therapy. We hypothesize that gender is a key factor in culture-induced stemness of adult stem cells. Our goal is to provide new evidence supporting gender effects on stroke and stem cells for the pur...
Source: CNS Neuroscience and Therapeutics - November 15, 2014 Category: Neuroscience Authors: Pabón MM, Ji XM, Fernandez JW, Borlongan CV Tags: CNS Neurosci Ther Source Type: research

Stem Cell Therapy for Abrogating Stroke-Induced Neuroinflammation and Relevant Secondary Cell Death Mechanisms
Publication date: Available online 23 July 2017 Source:Progress in Neurobiology Author(s): Connor Stonesifer, Sydney Corey, Shaila Ghanekar, Zachary Diamandis, Sandra A. Acosta, Cesar V. Borlongan Ischemic stroke is a leading cause of death worldwide. A key secondary cell death mechanism mediating neurological damage following the initial episode of ischemic stroke is the upregulation of endogenous neuroinflammatory processes to levels that destroy hypoxic tissue local to the area of insult, induce apoptosis, and initiate a feedback loop of inflammatory cascades that can expand the region of damage. Stem cell therapy has ...
Source: Progress in Neurobiology - July 23, 2017 Category: Neuroscience Source Type: research

Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats
In conclusion, enhanced expression of Ang1 and Tie2 in ischemic brain after BMSCs-CM treatment of stroke may contribute to the improved functional recovery after stroke in type 2 diabetic rats.
Source: Neuroscience Letters - February 26, 2017 Category: Neuroscience Source Type: research

CXCR7+ and CXCR4+ stem cells and neuron specific enolase in acute ischemic stroke patients
In conclusion, in this study NSE indicated some activity of the CD45−CD34 + CXCR7+, CD45−CD34 + and CD45−CD34 + CXCR4+ stem/progenitor cells in the first 7 days after ischemic stroke. Additionally, this study supports the thesis that NSE might be a valuable prognostic marker in acute ischemic stroke.
Source: Neurochemistry International - August 17, 2018 Category: Neuroscience Source Type: research

Endothelial Progenitor Cells: Therapeutic Perspective for Ischemic Stroke.
Abstract Endothelial progenitor cells (EPCs), which can be cultured in vitro from mononuclear cells in peripheral blood or bone marrow, express both hematopoietic stem cell and endothelial cell markers on their surface. They are believed to participate in endothelial repair and postnatal angiogenesis due to their abilities of differentiating into endothelial cells and secreting protective cytokines and growth factors. Mounting evidence suggests that circulating EPCs are reduced and dysfunctional in various diseases including hypertension, diabetes, coronary heart disease, and ischemic stroke. Therefore, EPCs have ...
Source: CNS Neuroscience and Therapeutics - December 11, 2012 Category: Neuroscience Authors: Zhao YH, Yuan B, Chen J, Feng DH, Zhao B, Qin C, Chen YF Tags: CNS Neurosci Ther Source Type: research

Timing and Dose Regimens of Marrow Mesenchymal Stem Cell Transplantation Affect the Outcomes and Neuroinflammatory Response After Ischemic Stroke.
CONCLUSIONS: Our data suggest that timing and cell dose of transplantation determine the therapeutic effects after focal ischemia by modulating poststroke neuroinflammation. PMID: 24393245 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 7, 2014 Category: Neuroscience Authors: Wang LQ, Lin ZZ, Zhang HX, Shao B, Xiao L, Jiang HG, Zhuge QC, Xie LK, Wang B, Su DM, Jin KL Tags: CNS Neurosci Ther Source Type: research

Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke.
Abstract Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-ba...
Source: CNS Neuroscience and Therapeutics - February 10, 2015 Category: Neuroscience Authors: Tang YH, Ma YY, Zhang ZJ, Wang YT, Yang GY Tags: CNS Neurosci Ther Source Type: research

Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke: Mechanistic Determination of the Causal Link Between Neurovascular Regeneration and Motor Functional Recovery
This study provides novel insights into the development of new restorative strategies for stroke recovery.
Source: ASN Neuro - August 8, 2016 Category: Neuroscience Authors: Cui, L., Wang, D., McGillis, S., Kyle, M., Zhao, L.-R. Tags: Original Article Source Type: research

Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke
Publication date: Available online 30 December 2016 Source:Neurochemistry International Author(s): Stephanie M. Davis, Keith R. Pennypacker During ischemic stroke, neurons and glia are subjected to damage during the acute and neuroinflammatory phases of injury. Production of reactive oxygen species (ROS) from calcium dysregulation in neural cells and the invasion of activated immune cells are responsible for stroke-induced neurodegeneration. Scientists have failed thus far to identify antioxidant-based drugs that can enhance neural cell survival and improve recovery after stroke. However, several groups have demonstrated ...
Source: Neurochemistry International - December 30, 2016 Category: Neuroscience Source Type: research

ZL006 promotes migration and differentiation of transplanted neural stem cells in male rats after stroke
In this study, we transplanted exogenous NSCs into the ipsilateral hemisphere of male rats in combination with ZL006 treatment after ischemic stroke. We show that ZL006 treatment facilitates the migration of transplanted NSCs into the ischemia‐injured area and promotes neuronal differentiation of these cells, which is not due to a direct effect of ZL006 on exogenous NSCs but is associated with increased phosphorylation of cAMP response element–binding protein (CREB) in neurons and favorable microenvironment. Moreover, improved functional outcome in the ZL006‐treated group was also found. Taken together, our data indi...
Source: Journal of Neuroscience Research - May 17, 2017 Category: Neuroscience Authors: Dong ‐Liang Wang, Xiao‐Dan Qian, Yu‐Hui Lin, Bin‐Bin Tian, Hai‐Ying Liang, Lei Chang, Hai‐Yin Wu, Dong‐Ya Zhu, Chun‐Xia Luo Tags: RESEARCH ARTICLE Source Type: research

Intra-arterial Stem Cell Therapy Diminishes Inflammasome Activation After Ischemic Stroke: a Possible Role of Acid Sensing Ion Channel 1a
This study offers a preliminary evidence of the role of IA MSCs in regulating inflammasome by modulating ASIC1a.
Source: Journal of Molecular Neuroscience - December 8, 2019 Category: Neuroscience Source Type: research

Epidermal neural crest stem cell transplantation as a promising therapeutic strategy for ischemic stroke.
CONCLUSION: These findings highlight the therapeutic effects of EPI-NCSCs transplantation, probably through simultaneous induction of neuronal and glial formation, as well as Bdnf over-expression in a rat model of ischemic stroke. PMID: 32281225 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - April 11, 2020 Category: Neuroscience Authors: Salehi MS, Pandamooz S, Safari A, Jurek B, Tamadon A, Namavar MR, Dianatpour M, Dargahi L, Azarpira N, Fattahi S, Shid Moosavi SM, Keshavarz S, Khodabandeh Z, Zare S, Nazari S, Heidari M, Izadi S, Poursadeghfard M, Borhani-Haghighi A Tags: CNS Neurosci Ther Source Type: research

Hippocampal neuroprotection mediated by secretome of human mesenchymal stem cells against experimental stroke
CONCLUSION: Our results suggest that hESC-MSC-CM could promote neurogenesis and protect brain tissue from ischemic injury, partly mediated by induction of angiogenesis and neurotrophic factors and inhibition of inflammatory and apoptotic factors expression.PMID:35715988 | DOI:10.1111/cns.13886
Source: CNS Neuroscience and Therapeutics - June 18, 2022 Category: Neuroscience Authors: Afsaneh Asgari Taei Leila Dargahi Pariya Khodabakhsh Mehdi Kadivar Maryam Farahmandfar Source Type: research