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New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Clinical Analysis and Management of Acquired Idiopathic Generalized Anhidrosis.
Authors: Satoh T Abstract Acquired idiopathic generalized anhidrosis (AIGA) is a sweating disorder characterized by inadequate sweating in response to heat stimuli such as high temperature, humidity, and physical exercise. Patients exhibit widespread nonsegmental hypohidrosis/anhidrosis without any apparent cause, but the palms, soles, and axillae are rarely affected. Heat stroke readily develops due to increased body temperature. AIGA commonly affects young males. Approximately 30-60% of patients show complications of cholinergic urticaria, also known as idiopathic pure sudomotor failure or hypohidrotic cholinergi...
Source: Current Problems in Dermatology - September 3, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research

Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - July 24, 2014 Category: Dermatology Authors: A. Fukunaga, M. Hatakeyama, M. Tsujimoto, Y. Oda, K. Washio, C. Nishigori Tags: Correspondence Source Type: research

Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis.
This article is protected by copyright. All rights reserved. PMID: 25060903 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - July 24, 2014 Category: Dermatology Authors: Fukunaga A, Hatakeyama M, Tsujimoto M, Oda Y, Washio K, Nishigori C Tags: Br J Dermatol Source Type: research