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A study of the correlation between stroke and gut microbiota over the last 20years: a bibliometric analysis
ConclusionFindings suggest that in the next 10 years, the number of publications produced annually may increase significantly. Future research trends tend to concentrate on the mechanisms of stroke and gut microbiota, with the inflammation and immunological mechanisms, TMAO, and fecal transplantation as hotspots. And the relationship between these mechanisms and a particular cardiovascular illness may also be a future research trend.
Source: Frontiers in Microbiology - June 7, 2023 Category: Microbiology Source Type: research

A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Clin Microbiol Rev. 2022 Jan 19;35(1):e0033820. doi: 10.1128/CMR.00338-20. Epub 2022 Jan 5.ABSTRACTThe human body is full of an extensive number of commensal microbes, consisting of bacteria, viruses, and fungi, collectively termed the human microbiome. The initial acquisition of microbiota occurs from both the external and maternal environments, and the vast majority of them colonize the gastrointestinal tract (GIT). These microbial communities play a central role in the maturation and development of the immune system, the central nervous system, and the GIT system and are also responsible for essential metabolic pathways...
Source: Clinical Microbiology Reviews - January 5, 2022 Category: Microbiology Authors: Shokufeh Ghasemian Sorboni Hanieh Shakeri Moghaddam Reza Jafarzadeh-Esfehani Saman Soleimanpour Source Type: research

Gut microbes impact stroke severity via the trimethylamine N-oxide pathway
Cell Host Microbe. 2021 Jun 10:S1931-3128(21)00230-4. doi: 10.1016/j.chom.2021.05.002. Online ahead of print.ABSTRACTClinical studies have demonstrated associations between circulating levels of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk. However, a causal role of gut microbes in stroke has not yet been demonstrated. Herein we show that gut microbes, through dietary choline and TMAO generation, directly impact cerebral infarct size and adverse outcomes following stroke. Fecal microbial transplantation from low- versus high-TMAO-producing human subjects into germ-free mice s...
Source: Cell Host and Microbe - June 17, 2021 Category: Microbiology Authors: Weifei Zhu Kymberleigh A Romano Lin Li Jennifer A Buffa Naseer Sangwan Prem Prakash Aaron N Tittle Xinmin S Li Xiaoming Fu Charlie Androjna Anthony J DiDonato Kimberly Brinson Bruce D Trapp Michael A Fischbach Federico E Rey Adeline M Hajjar Joseph A DiDo Source Type: research

Fecal Microbiota Transplantation in Neurological Disorders
Conclusions: Preliminary literature suggests that FMT may be a promising treatment option for several neurological disorders. However, available evidence is still scanty and some contrasting results were observed. A limited number of studies in humans have been performed or are ongoing, while for some disorders only animal experiments have been conducted. Large double-blinded randomized controlled trials are needed to further elucidate the effect of FMT in neurological disorders.
Source: Frontiers in cellular and infection microbiology - March 23, 2020 Category: Microbiology Source Type: research