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Total 99 results found since Jan 2013.

Risk factors for small intestinal bacterial overgrowth in patients with acute ischaemic stroke
Conclusion. The prevalence of SIBO in patients with AIS was 28.8 %. TG and Hcy levels are independent risk factors for SIBO in patients with AIS. Both markers had good predictive value for the occurrence of SIBO. In the future, we should actively utilize these indicators to prevent intestinal flora imbalance and the occurrence of SIBO.PMID:36762525 | DOI:10.1099/jmm.0.001666
Source: Journal of Medical Microbiology - February 10, 2023 Category: Microbiology Authors: Yang Liu Min Chu Daosheng Wang Yunhe Luo Zhuohang Liu Jing Zhao Source Type: research

The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis
Conclusions: The Mtb mutant DeltakstD strain, which is unable to use cholesterol as a source of carbon and energy, has a limited ability to multiply in resting M[latin capital letter o with stroke] following infection, reflecting a failure of the DeltakstD strain to inhibit the TLR2-dependent bactericidal activity of resting M[latin capital letter o with stroke].
Source: BMC Microbiology - Latest articles - February 20, 2013 Category: Microbiology Authors: Marta BrzezinskaIzabela SzulcAnna BrzostekMagdalena KlinkMichal KielbikZofia SulowskaJakub PawelczykJaroslaw Dziadek Source Type: research

Re-initiation of Oral Food Intake Following Enteral Nutrition Alters Oral and Gut Microbiota Communities
This study tried to clarify that re-initiating oral food intake could modify the composition of oral/gut microbial communities in patients with dysphagia. From 78 patients with sub-acute stage of stroke, 11 complete tube feeding subjects without taking antibiotics were enrolled and received rehabilitation for re-initiation of oral food intake, and 8 subjects were brought back to complete oral feeding. Oral and gut microbiota community profiles were evaluated using 16S rRNA sequencing of the saliva and feces samples before and after re-initiation of oral food intake in patients recovering from enteral nutrition under the sa...
Source: Frontiers in cellular and infection microbiology - December 19, 2019 Category: Microbiology Source Type: research

F1FO ATP synthase molecular motor mechanisms
The F-ATP synthase, consisting of F1 and FO motors connected by a central rotor and the stators, is the enzyme responsible for synthesizing the majority of ATP in all organisms. The F1 (αβ)3 ring stator contains three catalytic sites. Single-molecule F1 rotation studies revealed that ATP hydrolysis at each catalytic site (0°) precedes a power-stroke that rotates subunit-γ 120° with angular velocities that vary with rotational position. Catalytic site conformations vary relative to subunit-γ position (βE, empty; βD, ADP bound; βT, ATP-bound). During a power stroke, βE binds ATP (0°–60°) and βD releases ADP (6...
Source: Frontiers in Microbiology - August 23, 2022 Category: Microbiology Source Type: research

Multi-omics reveals specific host metabolism-microbiome associations in intracerebral hemorrhage
In conclusion, microbiome-related metabolites in ICH patients was associated with the severity of ICH, the microbiota-host co-metabolites may be a potential may be potential therapeutic targets.
Source: Frontiers in cellular and infection microbiology - December 22, 2022 Category: Microbiology Source Type: research

Gut microbiota and cerebrovascular diseases: a Mendelian randomization study
ConclusionThis MR analysis indicates that there exists a beneficial or detrimental causal effect of gut microbiota composition on cerebrovascular disease. And SBP and T2D may play mediating role in this process.
Source: Frontiers in Microbiology - August 10, 2023 Category: Microbiology Source Type: research

Fecal Microbiota Transplantation in Neurological Disorders
Conclusions: Preliminary literature suggests that FMT may be a promising treatment option for several neurological disorders. However, available evidence is still scanty and some contrasting results were observed. A limited number of studies in humans have been performed or are ongoing, while for some disorders only animal experiments have been conducted. Large double-blinded randomized controlled trials are needed to further elucidate the effect of FMT in neurological disorders.
Source: Frontiers in cellular and infection microbiology - March 23, 2020 Category: Microbiology Source Type: research

The roles and mechanisms of gut microbiome and metabolome in patients with cerebral infarction
As the most common type of stroke, ischemic stroke, also known as cerebral infarction (CI), with its high mortality and disability rate, has placed a huge burden on social economy and public health. Treatment methods for CI mainly include thrombectomy, thrombolysis, drug therapy, and so on. However, these treatments have certain timeliness and different side effects. In recent years, the gut-brain axis has become a hot topic, and its role in nervous system diseases has been confirmed by increasing evidences. The intestinal microbiota, as an important part of the gut-brain axis, has a non-negligible impact on the progressio...
Source: Frontiers in cellular and infection microbiology - January 25, 2023 Category: Microbiology Source Type: research

Kocuria kristinae endocarditis related to diabetic foot infection.
We report an unusual case of endocarditis occurring in a 74-year-old man with a history of systemic hypertension, diabetes mellitus and minor amputation for left forefoot ulcer. The patient was hospitalized for vacuum-assisted closure therapy to aid in wound healing. After the first treatment session, the patient reported abdominal pain with haematemesis and fever (40 °C). Owing to persistent fever, three blood cultures were performed, all positive for Kocuria kristinae. The identification was based on biochemical tests and automated systems. The speciation of the micro-organism was achieved with MALDI-TOF and then confir...
Source: Journal of Medical Microbiology - May 23, 2013 Category: Microbiology Authors: Citro R, Prota C, Greco L, Mirra M, Masullo A, Silverio A, Bossone E, Piscione F Tags: J Med Microbiol Source Type: research

Asymmetric dimethylarginine levels in patients with cutaneous anthrax: a laboratory analysis
Background: Asymmetric dimethylarginine (ADMA), the main endogenous inhibitor of nitric oxide synthase, is considered to be associated with endothelial dysfunction. High ADMA levels have been shown to be related with disorders causing vascular inflammation such as hypertension, hypercholesterolemia, atherosclerosis, chronic heart failure, stroke and sepsis. Cutaneous anthrax (CA) is a serious infectious disease which may cause vasculitis. The aim of the study was to investigate the serum ADMA levels in patients with CA. Methods: A total of 35 serum samples of the patients with CA and 18 control sera were tested for ADMA le...
Source: Annals of Clinical Microbiology and Antimicrobials - March 26, 2014 Category: Microbiology Authors: Mahmut SunnetciogluZafer MengelogluAli BaranMustafa KarahocagilMehmet TosunAbdulkadir KucukbayrakMehmet CeylanHayrettin AkdenizCenk Aypak Source Type: research

Amino acid supplementation enhances urokinase production by HT-1080 cells.
We describe here medium optimization for maximizing urokinase production by HT-1080 cells using supplementation of specific amino acids. The new specifically designed method resulted in 240 % increase in urokinase productivity. PMID: 24671568 [PubMed - as supplied by publisher]
Source: Journal of Industrial Microbiology and Biotechnology - March 27, 2014 Category: Microbiology Authors: Khaparde SS, Roychoudhury PK Tags: J Ind Microbiol Biotechnol Source Type: research

Periodontal Innate Immune Mechanisms Relevant to Atherosclerosis
This article is protected by copyright. All rights reserved.
Source: Oral Microbiology and Immunology - October 1, 2014 Category: Microbiology Authors: Salomon Amar, Marianne Engelke Tags: Original Article Source Type: research

Increased risk of dementia among chronic osteomyelitis patients
This study investigates whether COM increases the risk of dementia. Taiwanese National Health Insurance (NHI) inpatient claims were used to identify 17,238 patients newly diagnosed with COM from 2000 to 2008, and 68,944 age- and gender-matched patients without COM were randomly selected for comparison. Risks of dementia associated with COM and comorbidities, including hypertension, diabetes, stroke, hyperlipidemia, and depression, were evaluated using data from the end of 2011. Dementia risk was 1.6-fold higher (95 % confidence interval [CI]: 1.4–1.83) in the COM cohort than in the control group, calculated using the mu...
Source: European Journal of Clinical Microbiology and Infectious Diseases - January 1, 2015 Category: Microbiology Source Type: research