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Nutrition: Diets

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Total 303 results found since Jan 2013.

Deep Lipidomics in Human Plasma - Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation
Conclusions: We identified several lipids associated with cardiometabolic disease risk. A subset was beneficially altered by a dietary fat intervention, which supports substitution of dietary saturated FAs with unsaturated FAs as a potential tool for primary disease prevention.PMID:35422138 | DOI:10.1161/CIRCULATIONAHA.121.056805
Source: Circulation - April 15, 2022 Category: Cardiology Authors: Fabian Eichelmann Laury Sellem Clemens Wittenbecher Susanne J äger Olga Kuxhaus Marcela Prada Rafael Cuadrat Kim G Jackson Julie A Lovegrove Matthias B Schulze Source Type: research

Advances in Recurrent Stroke Prevention: Focus on Antithrombotic Therapies
Circ Res. 2022 Apr 15;130(8):1075-1094. doi: 10.1161/CIRCRESAHA.121.319947. Epub 2022 Apr 14.ABSTRACTThe past decade has seen significant advances in stroke prevention. These advances include new antithrombotic agents, new options for dyslipidemia treatment, and novel techniques for surgical stroke prevention. In addition, there is greater recognition of the benefits of multifaceted interventions, including the role of physical activity and dietary modification. Despite these advances, the aging of the population and the high prevalence of key vascular risk factors pose challenges to reducing the burden of stroke. Using a ...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Brian Mac Grory Shadi Yaghi Charlotte Cordonnier Luciano A Sposato Jose G Romano Seemant Chaturvedi Source Type: research

Impact of glomerular filtration rate estimation on cardiovascular events in elderly patients undergoing coronary angiography
Conclusions Kidney function, as manifested by eGFR, has a graded inverse association with the burden of cardiovascular comorbidities and long-term adverse events in elderly patients undergoing coronary angiography.
Source: Coronary Artery Disease - April 8, 2022 Category: Cardiology Tags: Original Research in CAD Source Type: research

Genetic connection of carotid atherosclerosis with coat color and body weight in an intercross between hyperlipidemic mouse strains
Physiol Genomics. 2022 Apr 6. doi: 10.1152/physiolgenomics.00006.2022. Online ahead of print.ABSTRACTAtherosclerosis in the carotid artery is a major cause of ischemic stroke and has a strong genetic component. The aim of this study was to identify genetic factors contributing to carotid atherosclerosis. 154 female F2mice were generated from an intercross between LP/J and BALB/cJ Apoe-null (Apoe-/-) mice and fed 12 weeks of Western diet. Atherosclerotic lesions, body weight, and coat color were measured and genotyping was performed using miniMUGA arrays. A significant QTL on chromosome (Chr) 7, named Cath20, and 5 suggesti...
Source: Atherosclerosis - April 6, 2022 Category: Cardiology Authors: Bilhan Chagari Lisa J Shi Evelyn Dao Alexander An Mei-Hua Chen Yongde Bao Weibin Shi Source Type: research

Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice
Genes (Basel). 2022 Mar 14;13(3):510. doi: 10.3390/genes13030510.ABSTRACTType 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. Apoe-null (Apoe-/-) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ Apoe-/- mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genoty...
Source: Atherosclerosis - March 25, 2022 Category: Cardiology Authors: Lisa J Shi Bilhan Chagari Alexander An Mei-Hua Chen Yongde Bao Weibin Shi Source Type: research

Update on Plant-Based Diets and Cardiometabolic Risk
AbstractPurpose of ReviewThe number of published studies on the health effects of plant-based diets has increased dramatically in the last decade. The purpose of this narrative review is to update the most recent evidence from large prospective cohort studies and meta-analyses on the effects of plant-based dietary patterns on cardiovascular outcomes and risk factors and total mortality.Recent FindingsMost new data from large prospective cohort studies carried out in the USA, Europe, and Asia continue to show inverse associations between plant-based diets and the incidence of ischemic heart disease and stroke, while less da...
Source: Current Atherosclerosis Reports - March 25, 2022 Category: Cardiology Source Type: research

Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice
This study was designed to explore the effects of TMAO on neuroinflammation, brain injury severity, and long-term neurologic function in mice with acute intracerebral hemorrhage (ICH). We fed mice with either a regular chow diet or a chow diet supplemented with 1.2% choline pre- and post-ICH. In this study, we measured serum levels of TMAO with ultrahigh-performance liquid chromatography-tandem mass spectrometry at 24 h and 72 h post-ICH. The expression level of P38-mitogen-protein kinase (P38-MAPK), myeloid differentiation factor 88 (MyD88), high-mobility group box1 protein (HMGB1), and interleukin-1β (IL-1β) around hem...
Source: Atherosclerosis - March 4, 2022 Category: Cardiology Authors: Caizhen Li Li Zhu Yinming Dai Zhiying Zhang Leo Huang Tom J Wang Peiji Fu Yinuo Li Jian Wang Chao Jiang Source Type: research

A Comorbid Rat Model of Neuroendocrine-Immune System Alterations Under the Impact of Risk Factors for Stroke
Front Aging Neurosci. 2022 Jan 20;13:827503. doi: 10.3389/fnagi.2021.827503. eCollection 2021.ABSTRACTHypercholesterolemia and carotid atherosclerosis contribute to the etiology of stroke. However, there has been a lack of appropriate comorbid animal models incorporating some of the ubiquitous characteristics that precede strokes. Curcumin is a natural active polyphenolic compound extracted from the rhizoma of Curcuma longa L. which possesses comprehensive bioactivities. The present study aimed to evaluate whether neurobehavioral deficits, neuroendocrine-immune dysregulations and cerebral microcirculation dysfunction, are ...
Source: Atherosclerosis - February 7, 2022 Category: Cardiology Authors: Bailiu Ya Xuezhi Li Jingyi Wang Mingsheng Zhao Ting Yu Haiying Wang Qing Xin Qinqin Wang Xin Mu Xuanyu Dong Yang Gao Huabao Xiong Hui Zhang Source Type: research