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Specialty: Cardiology
Condition: Ischemic Stroke
Drug: Insulin
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Total 52 results found since Jan 2013.
Insulin resistance estimated by estimated glucose disposal rate predicts outcomes in acute ischemic stroke patients
In this study, we...
Source: Cardiovascular Diabetology - August 26, 2023 Category: Cardiology Authors: Zhengzhao Lu, Yunyun Xiong, Xueyan Feng, Kaixuan Yang, Hongqiu Gu, Xingquan Zhao, Xia Meng and Yongjun Wang Tags: Research Source Type: research
Glyoxal in hyperglycaemic ischemic stroke – a cohort study
Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even in the absence of pre-existing diabetes. However, in clinical trials treatment of elevated glucose levels with insulin did ...
Source: Cardiovascular Diabetology - July 12, 2023 Category: Cardiology Authors: Sina Rhein, Julica Inderhees, Oliver Herrmann, Alaa Othman, Kimberly Begemann, Thomas Fleming, Peter P. Nawroth, Karel D. Klika, Rakad Isa, Inke R. K önig, Georg Royl and Markus Schwaninger Tags: Research Source Type: research
Association between triglyceride-glucose index and all-cause mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database
The triglyceride-glucose (TyG) index was significantly associated with insulin resistance (IR). Several studies have validated the effect of TyG index on cerebrovascular disease. However, the value of TyG inde...
Source: Cardiovascular Diabetology - June 13, 2023 Category: Cardiology Authors: Weimin Cai, Jun Xu, Xiao Wu, Zhuoyan Chen, Liuwei Zeng, Xian Song, Yuan Zeng and Fujun Yu Tags: Research Source Type: research
Five-Year Changes in Inflammatory, Metabolic, and Oxidative Biomarkers and 10-Year Cardiovascular Disease Incidence: The REGICOR Cohort Study
Int J Mol Sci. 2023 Apr 27;24(9):7934. doi: 10.3390/ijms24097934.ABSTRACTIschemic cardiovascular diseases (CVD) originate from an imbalance between atherosclerotic plaque formation, instability, and endothelial healing dynamics. Our aim was to examine the relationship between 5-year changes in inflammatory, metabolic, and oxidative biomarkers and 10-year CVD incidence in a population without previous CVD. This was a prospective cohort study of individuals aged 35-74 years (n = 419) randomly selected from 5263 REGICOR participants without CVD recruited in 2005. Biomarkers were measured at baseline and in 2010. Participants ...
Source: Atherosclerosis - May 13, 2023 Category: Cardiology Authors: Anna Camps-Vilaro Isaac Subirana Rafel Ramos Miguel Cainzos-Achirica Helena Tizon-Marcos Montse Fito Irene R Degano Jaume Marrugat Source Type: research
Triglyceride-glucose index, symptomatic intracranial artery stenosis and recurrence risk in minor stroke patients with hypertension
CONCLUSION: TyG is a significant risk factor for sICAS in hypertensive patients, and there is a synergistic effect of sICAS and higher TyG on ischemic stroke recurrence.TRIAL REGISTRATION NUMBER: The study was registered on 16 August 2019 at https://www.chictr.org.cn/showprojen.aspx?proj=41160 (No. ChiCTR1900025214).PMID:37076850 | DOI:10.1186/s12933-023-01823-6
Source: Atherosclerosis - April 19, 2023 Category: Cardiology Authors: Yongle Wang Tingting Liu Yanan Li Kaili Zhang Haimei Fan Jing Ren Juan Li Yali Li Xinyi Li Xuemei Wu Junhui Wang Lixi Xue Xiaolei Gao Yuping Yan Gaimei Li Qingping Liu Wenhua Niu Wenxian Du Yuting Liu Xiaoyuan Niu Source Type: research
Triglyceride-glucose index and the incidence of stroke: A meta-analysis of cohort studies
CONCLUSION: A higher TyG index may be independently associated with a higher risk of stroke in individuals without stroke at baseline. The aforementioned findings need to be verified by a large-scale prospective cohort study to further clarify the underlying pathophysiological mechanism between the TyG index and stroke.PMID:36686534 | PMC:PMC9845890 | DOI:10.3389/fneur.2022.1033385
Source: Atherosclerosis - January 23, 2023 Category: Cardiology Authors: Canlin Liao Haixiong Xu Tao Jin Ke Xu Zhennan Xu Lingzhen Zhu Mingfa Liu Source Type: research
The impact of triglyceride-glucose index on ischemic stroke: a systematic review and meta-analysis
Strokes significantly impair quality of life and incur high economic and societal burdens. The triglyceride and glucose (TyG) index is a biochemical marker of insulin resistance (IR) and may have important val...
Source: Cardiovascular Diabetology - January 6, 2023 Category: Cardiology Authors: Ying Yang, Xiangting Huang, Yuge Wang, Lin Leng, Jiapei Xu, Lei Feng, Shixie Jiang, Jiang Wang, Yanrong Yang, Gaofeng Pan, Bing Jiang, Yan Wang and Lan Chen Tags: Review Source Type: research
Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
Front Endocrinol (Lausanne). 2022 Dec 15;13:1092431. doi: 10.3389/fendo.2022.1092431. eCollection 2022.ABSTRACTThe pathological condition of insulin resistance prevents the neuroprotective effects of insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk factor for ischemic stroke, accelerates the formation of thrombosis and promotes the development of atherosclerosis, both of which are major mechanisms of ischemic stroke. Additionally, insulin resistance negatively affects the prognosis of patients with ischemic stroke regardless of whether the patient has diabetes, but the mechanisms ...
Source: Atherosclerosis - January 2, 2023 Category: Cardiology Authors: Peng-Fei Ding Hua-Sheng Zhang Jie Wang Yong-Yue Gao Jian-Nan Mao Chun-Hua Hang Wei Li Source Type: research
Triglyceride-glucose index as a prognostic marker after ischemic stroke or transient ischemic attack: a prospective observational study
CONCLUSIONS: TyG index is associated with cervicocerebral atherosclerosis and the MACE risk after a stroke, suggesting the potential value of TyG index to optimize the risk stratification of stroke patients. Trial registration URL: https://upload.umin.ac.jp . Unique identifier: UMIN000031913.PMID:36451149 | DOI:10.1186/s12933-022-01695-2
Source: Atherosclerosis - November 30, 2022 Category: Cardiology Authors: Takao Hoshino Takafumi Mizuno Kentaro Ishizuka Shuntaro Takahashi Satoko Arai Sono Toi Kazuo Kitagawa Source Type: research
Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning
CONCLUSION: M1 macrophages is an important cause of unstable plaque formation, and CD68, PAM, and IGFBP6 could be used as diagnostic markers to identify unstable plaques effectively.PMID:36211422 | PMC:PMC9537477 | DOI:10.3389/fimmu.2022.956078
Source: Atherosclerosis - October 10, 2022 Category: Cardiology Authors: Jing Wang Zijian Kang Yandong Liu Zifu Li Yang Liu Jianmin Liu Source Type: research
Heterogeneity of outcomes within diabetic patients with atrial fibrillation on edoxaban: a sub-analysis from the ETNA-AF Europe registry
ConclusionsIn a real-world cohort of AF patients on edoxaban, diabetes requiring insulin therapy, rather than the presence of diabetes per se, appears to be an independent factor affecting the occurrence of thromboembolic events during follow-up. Regardless of the diabetes type, diabetic patients had a lower survival compared with those without diabetes.Graphical abstract
Source: Clinical Research in Cardiology - August 17, 2022 Category: Cardiology Source Type: research
Fibronectin containing alternatively spliced extra domain A interacts at the central and c-terminal domain of Toll-like receptor-4
In conclusion, FN-EDA interacts and forms a stable complex through its "SPEDGIRELF" sequence at the central and C-terminal domain region of TLR4. The revelation of FN-EDA and TLR4 interacting sites may help design novel therapeutics for drug discovery research.PMID:35690624 | DOI:10.1038/s41598-022-13622-2
Source: Atherosclerosis - June 11, 2022 Category: Cardiology Authors: Shubhangi Gupta Azeem Ali Saurabh Pandey Imran A Khan Prem Prakash Source Type: research
