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Specialty: Molecular Biology
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Total 1564 results found since Jan 2013.
Potential role of Nigella Sativa and its Constituent (Thymoquinone) in Ischemic Stroke
Curr Mol Med. 2023 Apr 10. doi: 10.2174/1566524023666230410101724. Online ahead of print.ABSTRACTIschemic stroke is one of the major causes of global mortality, which puts great demands on health systems and social welfare. Ischemic stroke is a complex pathological process involving a series of mechanisms such as ROS accumulation, Ca2 + overload, inflammation, and apoptosis. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients has led scientists to find new treatments. The use of herbal medicine, as an alternative or complementary therapy, is increasing worldwide. For centurie...
Source: Current Molecular Medicine - April 11, 2023 Category: Molecular Biology Authors: Shakiba Azami Fatemeh Forouzanfar Source Type: research
N-Terminomic Changes of Neurons During Excitotoxicity Reveal Proteolytic Events Associated with Synaptic Dysfunctions and Potential Targets for Neuroprotection
Mol Cell Proteomics. 2023 Apr 6:100543. doi: 10.1016/j.mcpro.2023.100543. Online ahead of print.ABSTRACTExcitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by over-stimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxicity, the identity of affected proteins and mechanisms by which they induce neuronal cell death remain unclear. To address this, we used quantitative N-terminomics to identify proteins modified by proteolysis in neurons undergoing excitotoxic cell death. We found that most proteolytically pr...
Source: Molecular and Cellular Proteomics : MCP - April 8, 2023 Category: Molecular Biology Authors: S Sadia Ameen Nane Griem-Krey Antoine Dufour M Iqbal Hossain Ashfaqul Hoque Sharelle Sturgeon Harshal Nandurkar Dominik F Draxler Robert L Medcalf Mohd Aizuddin Kamaruddin Isabelle S Lucet Michael G Leeming Dazhi Liu Amardeep Dhillon Jet Phey Lim Faiza Ba Source Type: research
Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort
CONCLUSION: The results showed that CC genotype for rs2241883 polymorphism is related to an increased risk of the obesity in dominant and codominant models in a population of MASHAD study cohort.PMID:37026586 | DOI:10.1002/mgg3.2173
Source: Molecular Medicine - April 7, 2023 Category: Molecular Biology Authors: Mohsen Valizadeh Malihe Aghasizadeh Fatemeh Shaghi Ali Moradi Haleh S T Afshari Reza Zare-Feyzabadi Maryam Saberi-Karimian Mohammad Hashemi Fatemeh N S Doust Mohsen Nematy Ensieh A Bahre Seyed H Aghaei-Bakhtiari Hamideh Ghazizadeh Hamideh Safarian-Bana Ni Source Type: research
Profiling of Targeted miRNAs (8-nt) for the Genes Involved in Type 2 Diabetes Mellitus and Cardiac Hypertrophy
Mol Biol (Mosk). 2023 Mar-Apr;57(2):360-361.ABSTRACTType 2 Diabetes Mellitus (T2DM) and cardiac hypertrophy (CH) are among the top ten leading cause of deaths, worldwide. T2DM and cardiac hypertrophy are the chronic diseases, have close association and direct life-threatening complications like stroke, myocardial infarction, retinopathy, nephropathy, and limb amputation. In addition to other medical approaches, miRNAs-based strategy is considered most efficient for early detection of chronic diseases and also has potential for the treatment of T2DM and cardiac hypertrophy like it is being used for cancer in clinical trials...
Source: Molekuliarnaia Biologiia - March 31, 2023 Category: Molecular Biology Authors: K Hussain A Ishtiaq I Mushtaq I Murtaza Source Type: research
Complex cerebrovascular diseases in Roberts syndrome caused by novel biallelic ESCO2 variations
CONCLUSIONS: We describe complex cerebrovascular diseases in Roberts syndrome caused by novel ESCO2 biallelic variations. This case expands not only the cerebral involvement in Roberts syndrome but also the disease spectrum of the neuroimaging triad with leukoencephalopathy, calcifications, and cysts.PMID:37002187 | DOI:10.1002/mgg3.2177
Source: Molecular Medicine - March 31, 2023 Category: Molecular Biology Authors: Shuang He Shuai Chen Shu-Jian Li Jie-Wen Zhang Xin-Liang Liang Source Type: research
Profiling of Targeted miRNAs (8-nt) for the Genes Involved in Type 2 Diabetes Mellitus and Cardiac Hypertrophy
Mol Biol (Mosk). 2023 Mar-Apr;57(2):360-361.ABSTRACTType 2 Diabetes Mellitus (T2DM) and cardiac hypertrophy (CH) are among the top ten leading cause of deaths, worldwide. T2DM and cardiac hypertrophy are the chronic diseases, have close association and direct life-threatening complications like stroke, myocardial infarction, retinopathy, nephropathy, and limb amputation. In addition to other medical approaches, miRNAs-based strategy is considered most efficient for early detection of chronic diseases and also has potential for the treatment of T2DM and cardiac hypertrophy like it is being used for cancer in clinical trials...
Source: Molekuliarnaia Biologiia - March 31, 2023 Category: Molecular Biology Authors: K Hussain A Ishtiaq I Mushtaq I Murtaza Source Type: research
