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Total 1564 results found since Jan 2013.
Detection of Ferroptosis in Models of Brain Diseases
Methods Mol Biol. 2023;2712:233-251. doi: 10.1007/978-1-0716-3433-2_21.ABSTRACTFerroptosis is a regulated form of non-apoptotic cell death driven by iron-dependent lipid peroxidation. In the past decade, ferroptosis has been reported to be involved in the pathological role in the central nervous system degenerative diseases (e.g., Alzheimer's disease, Huntington's disease, and Parkinson's disease), stroke, traumatic brain injury, and brain tumor. However, how to reliably detect and classify ferroptosis from other cell death in pathological conditions remains a great challenge, especially in primary brain cells and brain ti...
Source: Mol Biol Cell - August 14, 2023 Category: Molecular Biology Authors: Danmin Shen Fei Yang Qian Li Source Type: research
Methods to Study Inflammasome Activation in the Central Nervous System: Immunoblotting and Immunohistochemistry
Methods Mol Biol. 2023;2696:223-238. doi: 10.1007/978-1-0716-3350-2_15.ABSTRACTThe inflammasome is a multiprotein complex that is responsible for mounting an innate immune response through the activation of caspase-1 and the cleavage of interleukin-1β. This multiprotein complex plays an important role in a variety of central nervous system (CNS) diseases and conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and traumatic brain injury, among others. Here we describe methodological procedures to carry out immunoblotting and immunohistochemical techniques used to study inflammasome sign...
Source: Molecular Medicine - August 14, 2023 Category: Molecular Biology Authors: Brianna Cyr Juan Pablo de Rivero Vaccari Source Type: research
Correlation between Hepatocyte Growth Factor (HGF) with D-Dimer and Interleukin-6 as Prognostic Markers of Coagulation and Inflammation in Long COVID-19 Survivors
Curr Issues Mol Biol. 2023 Jul 8;45(7):5725-5740. doi: 10.3390/cimb45070361.ABSTRACTIn general, an individual who experiences the symptoms of Severe Acute Respiratory Syndrome Coronavirus 2 or SARS-CoV-2 infection is declared as recovered after 2 weeks. However, approximately 10-20% of these survivors have been reported to encounter long-term health problems, defined as 'long COVID-19', e.g., blood coagulation which leads to stroke with an estimated incidence of 3%, and pulmonary embolism with 5% incidence. At the time of infection, the immune response produces pro-inflammatory cytokines that stimulate stromal cells to pro...
Source: Current Issues in Molecular Biology - July 28, 2023 Category: Molecular Biology Authors: Bena Zaira Trilis Yulianti Jutti Levita Source Type: research
