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Clinical-CT mismatch defined NIHSS ≥ 8 and CT-ASPECTS ≥ 9 as a reliable marker of candidacy for intravenous thrombolytic therapy in acute ischemic stroke
by Hung-Ming Wu, I-Hui Lee, Chao-Bao Luo, Chih-Ping Chung, Yung-Yang Lin BackgroundClinical-diffusion mismatch between stroke severity and diffusion-weighted imaging lesion volume seems to identify stroke patients with penumbra. However, urgent magnetic resonance imaging is sometimes inaccessible or contraindicated. Thus, we hypothesized that using brain computed tomography (CT) to determine a baseline “clinical-CT mismatch” may also predict the responses to thrombolytic therapy. MethodsBrain CT lesions were measured using the Alberta Stroke Program Early CT Score (ASPECTS). A total of 104 patients were included: 79 pa...
Source: PLoS One - April 30, 2021 Category: Biomedical Science Authors: Hung-Ming Wu Source Type: research

Caveolin-1 and MLRs: A potential target for neuronal growth and neuroplasticity after ischemic stroke.
Authors: Zhong W, Huang Q, Zeng L, Hu Z, Tang X Abstract Ischemic stroke is a leading cause of morbidity and mortality worldwide. Thrombolytic therapy, the only established treatment to reduce the neurological deficits caused by ischemic stroke, is limited by time window and potential complications. Therefore, it is necessary to develop new therapeutic strategies to improve neuronal growth and neurological function following ischemic stroke. Membrane lipid rafts (MLRs) are crucial structures for neuron survival and growth signaling pathways. Caveolin-1 (Cav-1), the main scaffold protein present in MLRs, targets man...
Source: International Journal of Medical Sciences - November 2, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors
ConclusionsDespite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables.
Source: Advances in Medical Sciences - July 11, 2018 Category: Biomedical Science Source Type: research

Pathophysiological significance of protein hydrophobic interactions: an emerging hypothesis
Fibrinogen is a unique protein that is converted into an insoluble fibrin in a single enzymatic event, which is a characteristic feature of fibrinogen due to its susceptibility to fibrinolytic degradation and dissolution. Although thrombosis is a result of activated blood coagulation, no explanation is being offered for the persistent presence of fibrin deposits in the affected organs. A classic example is stroke, in which the thrombolytic therapy is effective only during the first 3 –4 hours after the onset of thrombosis.
Source: Medical Hypotheses - October 25, 2017 Category: Biomedical Science Authors: Marek Kieliszek, Boguslaw Lipinski Source Type: research

Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors.
CONCLUSIONS: Despite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables. PMID: 28985592 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - October 3, 2017 Category: Biomedical Science Authors: Colello MJ, Ivey LE, Gainey J, Faulkner RV, Johnson A, Brechtel L, Madeline L, Nathaniel TI Tags: Adv Med Sci Source Type: research

Pharmacological thrombolysis for acute ischemic stroke treatment: Gender differences in clinical risk factors
Conclusions Despite similarities in different areas of stroke care for both men and women, more women with diabetes, previous history of stroke and higher NIH scores are more likely to be excluded from thrombolytic therapy. Men with a previous history of stroke, hypertension and higher NIH scores are more likely to be excluded rtPA even after adjustment for confounding variables.
Source: Advances in Medical Sciences - October 3, 2017 Category: Biomedical Science Source Type: research