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Effects of vitamin B < sub > 12 < /sub > deficiency on risk and outcome of ischemic stroke
Clin Biochem. 2023 May 27:110591. doi: 10.1016/j.clinbiochem.2023.110591. Online ahead of print.ABSTRACTIschemic stroke is the most prevalent form of stroke and has a high incidence in older adults, characterized by high morbidity, mortality, disability, and recurrence rate. Vitamin B12 deficiency is prevalent in the elderly and has been reported to be associated with ischemic stroke. The mechanisms maybe include the disorder of methylation metabolism, accumulation of toxic metabolites, immune dysfunction, affecting gut microbial composition and gut-brain immune homeostasis, and toxic stress responses to the brain. Vitamin...
Source: Clinical Biochemistry - May 29, 2023 Category: Biochemistry Authors: Li Zhou Xiaosong Song Jiani Wang Yongjun Tan Qin Yang Source Type: research

Serum 25-hydroxyvitamin D, cardiovascular risk markers, and incident cardiovascular disease in a high risk community population
CONCLUSIONS: Vitamin D status likely offers no additional information on CVD risk over conventional laboratory-measured risk markers.PMID:33831385 | DOI:10.1016/j.clinbiochem.2021.04.001
Source: Clinical Biochemistry - April 8, 2021 Category: Biochemistry Authors: Jaeun Yang Yuan Dong Christopher T Naugler Lawrence de Koning Source Type: research

Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?
Abstract Hypertension is the leading cause of preventable mortality worldwide, contributing to over 9 million deaths per annum, predominantly owing to cardiovascular disease. The association of obesity, physical inactivity and alcohol with elevated blood pressure (BP) is firmly established. Weight loss or other dietary strategies, such as the Dietary Approaches to Stop Hypertension (DASH) diet, have been shown to be effective in lowering BP. Additionally, specific nutrients are recognised to contribute to BP, with higher sodium intake linked with an increased risk of hypertension, while potassium is associated wit...
Source: Biochimie - April 10, 2020 Category: Biochemistry Authors: Psara E, Pentieva K, Ward M, McNulty H Tags: Biochimie Source Type: research

INR and vitamin K antagonists management by the primary care physicians in Normandy.
Abstract The main objective of our study was to carry out a statement of the knowledge and the management of the VKA by the General Practitioners (GPs) of Normandy and to evaluate their experience of the use of DOA with a questionnaire; 471 of the 1951 GPs requested responded. When the INR was stable in a patient affected with atrial fibrillation, the GPs participating dosed it again 4 weeks later, modified the dosage when the INR was below 1.9 or upper 3.2. The risk of stroke was overestimated to 6.2% per year with fluindione and to 31.5% without curative anticoagulation. The mean TTR was overstated to 84%. When ...
Source: Annales de Biologie Clinique - March 31, 2020 Category: Biochemistry Authors: Druilhe L, Humbert X Tags: Ann Biol Clin (Paris) Source Type: research

Implication of Homocysteine in protein quality control processes.
Abstract Homocysteine (Hcy) is a key metabolite generated during methionine metabolism. The elevated levels of Hcy in the blood is reffered as hyperhomocystenimeia (HHcy). The HHcy is caused by imapired metabolism/deficiency of either folate, or B12 or defects in Hcy metabolism. Accumulating evidence suggests that HHcy is associated with cardiovascular and brain diseases including atherosclerosis, endothelial injury, and stroke etc. Vitamin B12 (cobalamin; B12) is a water-soluble vitamin essential for two metabolic reactions. It acts as a co-factor for methionine synthase and L-methylmalonyl-CoA mutase. Besides, i...
Source: Biochimie - June 29, 2019 Category: Biochemistry Authors: Reddy VS, Trinath J, Reddy GB Tags: Biochimie Source Type: research

Long-term warfarin therapy and biomarkers for osteoporosis and atherosclerosis
Conclusions Long-term warfarin therapy may be associated with bone mineral loss and vascular calcification in 60–80year old hypertensive patients.
Source: BBA Clinical - August 12, 2015 Category: Biochemistry Source Type: research

Cardiovascular Complications of Calcium Supplements
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - December 10, 2014 Category: Biochemistry Authors: Ian R Reid, Sarah M Bristow, Mark J Bolland Tags: Article Source Type: research