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Perceived Level of Life Enjoyment and Risk of Developing Disabling Dementia: The Japan Public Health Center-Based Study
DISCUSSION: A higher level of life enjoyment was associated with a lower risk of disabling dementia, particularly in the low-medium mental stress group. This finding suggests the importance of having life enjoyment by managing mental stress for reducing risk of disabling dementia.PMID:37718836 | DOI:10.1093/geronb/gbad129
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Tomokazu Tajima Ai Ikeda Takeshi Tanigawa Hiroyasu Iso Kazumasa Yamagishi Takumi Matsumura Nobufumi Yasuda Manami Inoue Shoichiro Tsugane Norie Sawada Japan Public Health Center –Based Study Group Source Type: research

Risk and population attributable fraction of stroke subtypes in Japan
CONCLUSION: Although there are differences according to the subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.PMID:37460296 | DOI:10.2188/jea.JE20220364
Source: Cancer Control - July 17, 2023 Category: Cancer & Oncology Authors: Hiroshi Yatsuya Kazumasa Yamagishi Yuanying Li Isao Saito Yoshihiro Kokubo Isao Muraki Manami Inoue Shoichiro Tsugane Hiroyasu Iso Norie Sawada Source Type: research

Serum folate and risk of disabling dementia: a community-based nested case-control study
CONCLUSION: In this nested case-control study with a long follow-up, low serum folate levels were associated with an increased risk of disabling dementia among Japanese individuals.PMID:37314940 | DOI:10.1080/1028415X.2023.2218533
Source: Cancer Control - June 14, 2023 Category: Cancer & Oncology Authors: Rie Kishida Kazumasa Yamagishi Ai Ikeda Mina Hayama-Terada Yuji Shimizu Isao Muraki Mitsumasa Umesawa Hironori Imano Tomoko Sankai Takeo Okada Akihiko Kitamura Masahiko Kiyama Hiroyasu Iso CIRCS Investigators Source Type: research

Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease 　- The Japan Public Health Center-Based Prospective Study
CONCLUSIONS: HF as the UCD was partly explained by CVD. The data imply that most HF deaths reported in vital statistics may be associated with underlying causes other than CVD.PMID:36948630 | DOI:10.1253/circj.CJ-22-0805
Source: Cancer Control - March 22, 2023 Category: Cancer & Oncology Authors: Isao Saito Kazumasa Yamagishi Yoshihiro Kokubo Hiroshi Yatsuya Hiroyasu Iso Norie Sawada Manami Inoue Shoichiro Tsugane Source Type: research

Dietary diversity and risk of late-life disabling dementia in middle-aged and older adults
CONCLUSIONS: Our findings indicate that eating a variety of foods may prevent disabling dementia only among women. Thus, the habit of consuming a variety of food items has important public health implications for women.PMID:36863290 | DOI:10.1016/j.clnu.2023.02.002
Source: Cancer Control - March 2, 2023 Category: Cancer & Oncology Authors: Rei Otsuka Shu Zhang Hikaru Ihira Norie Sawada Manami Inoue Kazumasa Yamagishi Nobufumi Yasuda Shoichiro Tsugane Source Type: research

Physical health risks of middle-aged people with low social independence: fatal diseases in men, and little attendance to cancer screenings in both sexes
CONCLUSIONS: In terms of current physical health, low-social-independent men have more fatal diseases. Both sexes with low social independence seldom attend cancer screenings and have an increased risk of developing progressive cancer in the future. At least in terms of non-smoking and non-drinking, they live healthier lives than the control group, and what makes low-social-independent men have various fatal diseases is still unclear.PMID:36846461 | PMC:PMC9948749 | DOI:10.7717/peerj.14904
Source: Cancer Control - February 27, 2023 Category: Cancer & Oncology Authors: Haruaki Naito Katsuya Nitta Misooja Lee Takeshi Ushigusa Motoki Osawa Takahiro Tabuchi Yasuhiro Kakiuchi Source Type: research

Vitamin D intake and all-cause and cause-specific mortality in Japanese men and women: the Japan Public Health Center-based prospective study
Eur J Epidemiol. 2023 Jan 31. doi: 10.1007/s10654-023-00968-8. Online ahead of print.ABSTRACTWhile higher circulating 25-hydroxyvitamin D concentrations have been reported to be associated with decreased risk of all-cause mortality, evidence on dietary vitamin D intake is limited and inconsistent. We investigated whether vitamin D intake is associated with all-cause and cause-specific mortality among Japanese adults. Participants were 42,992 men and 50,693 women who responded to the second survey of the Japan Public Health Center-based Prospective Study (1995-1998) and who were followed up for mortality through 2018. Dieta...
Source: Cancer Control - January 31, 2023 Category: Cancer & Oncology Authors: Akiko Nanri Tetsuya Mizoue Atsushi Goto Mitsuhiko Noda Norie Sawada Shoichiro Tsugane Japan Public Health Center-based Prospective Study Group Source Type: research

Study Protocol and Baseline Characteristics of Randomized Trial for Evaluating Secondary Prevention Efficacy of Combination Therapy-Statin and Eicosapentaenoic Acid: RESPECT-EPA, The Combination of a Randomized Control Trial and an Observational Biomarker Study
CONCLUSIONS: After this study is completed, we will have further evidence on whether a highly purified EPA is effective in reducing cardiovascular events for secondary prevention or not, as well as whether if EPA/AA ratio is a predictor for future cardiovascular events.PMID:36372250 | DOI:10.1016/j.ahj.2022.11.008
Source: Cancer Control - November 13, 2022 Category: Cancer & Oncology Authors: Yuji Nishizaki Katsumi Miyauchi Hiroshi Iwata Teruo Inoue Atsushi Hirayama Kazuo Kimura Yukio Ozaki Toyoaki Murohara Kenji Ueshima Yoshihiro Kuwabara Sachiko Tanaka-Mizuno Naotake Yanagisawa Tosiya Sato Hiroyuki Daida Source Type: research

Sex- and age-specific all-cause mortality in insomnia with hypnotics: Findings from Japan multi-institutional Collaborative Cohort Study
CONCLUSIONS: Our study revealed sex-age specific associations between hypnotic use and all-cause mortality.PMID:36240602 | DOI:10.1016/j.sleep.2022.09.020
Source: Cancer Control - October 14, 2022 Category: Cancer & Oncology Authors: Rintaro Sogawa Chisato Shimanoe Keitaro Tanaka Megumi Hara Yuichiro Nishida Takuma Furukawa Mako Nagayoshi Asahi Hishida Yoko Kubo Yasufumi Kato Isao Oze Hidemi Ito Yohko Nakamura Miho Kusakabe Shiroh Tanoue Chihaya Koriyama Sadao Suzuki Takahiro Otani Da Source Type: research

Associations Between Adherence to Evidence-Based, Stroke Quality Indicators and Outcomes of Acute Reperfusion Therapy
CONCLUSIONS: We demonstrated national marked and sustainable improvement in adherence to door-to-needle time, door-to-puncture time, and successful reperfusion from 2013 to 2017 in Japan in patients with acute ischemic stroke. Adhering to the key QIs substantially affected in-hospital outcomes, underlining the importance of monitoring the quality of care using evidence-based QIs and the nationwide Close The Gap-Stroke program.PMID:35971841 | DOI:10.1161/STROKEAHA.121.038483
Source: Cancer Control - August 16, 2022 Category: Cancer & Oncology Authors: Nice Ren Soshiro Ogata Eri Kiyoshige Kunihiro Nishimura Ataru Nishimura Ryu Matsuo Takanari Kitazono Takahiro Higashi Kuniaki Ogasawara Koji Iihara Close The Gap-Stroke, J-ASPECT Study Collaborators Source Type: research

Impact of the state of emergency on trends in the care of three major diseases at Showa University Hospital, Japan: a retrospective and descriptive study
CONCLUSIONS: This study showed a long-term decrease in cancer patient visits to Showa University Hospital since the beginning of the COVID-19 pandemic compared to the previous 3 years. It is also possible that medical care that would have been available may not have been provided due to the state of emergency, so it is necessary to follow up patients while keeping a close eye on measures other than infectious diseases.PMID:35968063 | PMC:PMC9351415 | DOI:10.15167/2421-4248/jpmh2022.63.2.2210
Source: Cancer Control - August 15, 2022 Category: Cancer & Oncology Authors: Akira Minoura Kouzou Murakami Masaaki Matoba Yoshinori Ito Yumi Kamijo Akatsuki Kokaze Source Type: research

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016
Sci Rep. 2022 Feb 28;12(1):3252. doi: 10.1038/s41598-022-06074-1.ABSTRACTTo determine whether increasing thrombectomy-capable hospitals with moderate comprehensive stroke center (CSC) capabilities is a valid alternative to centralization of those with high CSC capabilities. This retrospective, nationwide, observational study used data from the J-ASPECT database linked to national emergency medical service (EMS) records, captured during 2013-2016. We compared the influence of mechanical thrombectomy (MT) use, the CSC score, and the total EMS response time on the modified Rankin Scale score at discharge among patients with a...
Source: Cancer Control - March 1, 2022 Category: Cancer & Oncology Authors: Ai Kurogi Daisuke Onozuka Akihito Hagihara Kunihiro Nishimura Akiko Kada Manabu Hasegawa Takahiro Higashi Takanari Kitazono Tsuyoshi Ohta Nobuyuki Sakai Hajime Arai Susumu Miyamoto Tetsuya Sakamoto Koji Iihara J-ASPECT Study Collaborators Source Type: research

Impact of the preoperative body mass index on the postoperative outcomes in patients with completely resected non-small cell lung cancer: A retrospective analysis of 16,503 cases in a Japanese Lung Cancer Registry Study
Obesity is responsible for multiple chronic diseases, including type 2 diabetes, hypertension, coronary artery disease, stroke, and several types of cancer [1]. The body mass index (BMI) —as an easy-to obtain, acceptable proxy for thinness and fatness—has been found to be associated with health risk and death in many populations. According to the World Health Organization definition, the normal range of BMI is defined as 18.5 to
Source: Lung Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Koichi Fukumoto, Shoichi Mori, Yasushi Shintani, Jiro Okami, Hiroyuki Ito, Takashi Ohtsuka, Shinichi Toyooka, Takeshi Mori, Shun-ichi Watanabe, Hisao Asamura, Masayuki Chida, Hiroshi Date, Shunsuke Endo, Takeshi Nagayasu, Ryoichi Nakanishi, Etsuo Miyaoka, Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

The JPHC Study: Design and Some Findings on the Typical Japanese Diet
The Japan Public Health Center-based prospective Study conducted a baseline survey for 140 000 registered residents aged 40–69 years within 11 public health center areas nationwide in 1990–94. Five- and 10-year follow-up surveys were conducted to update information on lifestyle habits and health conditions. In total, 130 000 participants responded to at least one of the three questionnaire surveys, and 78 000 to all three. In addition, 60 000 participants provided blood samples on at least one of the two sampling times, and 23 000 on both. The subjects have been followed for vital status and the occurrence of c...
Source: Japanese Journal of Clinical Oncology - August 25, 2014 Category: Cancer & Oncology Authors: Tsugane, S., Sawada, N. Tags: Review Articles Source Type: research