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A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes
Adv Sci (Weinh). 2023 May 2:e2206854. doi: 10.1002/advs.202206854. Online ahead of print.ABSTRACTFollowing stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients. Nanozyme-based antioxidants are emerging to treat stroke through scavenging excessive ROS. However, most of nanozymes cannot efficiently scavenge ROS in neuronal cytosol and mitochondria, due to low-uptake abilities of neurons and barriers of organelle membranes, significantly limiting nanozymes' neuroprotective effects. To overcome this limitation, a man...
Source: Adv Data - May 2, 2023 Category: Epidemiology Authors: Jian Wang Yang Wang Xiakeerzhati Xiaohalati Qiangfei Su Jingwei Liu Bo Cai Wen Yang Zheng Wang Lin Wang Source Type: research

The Association between Inflammatory Markers in the Acute Phase of Stroke and Long-Term Stroke Outcomes: Evidence from a Population-Based Study of Stroke
Conclusion: CRP has a significant direct, yet weak, correlation to the severity of stroke. In addition, the level of CRP at admission may have a clinical implication to identify those at a higher risk of death or recurrence.Neuroepidemiology
Source: Neuroepidemiology - April 16, 2019 Category: Epidemiology Source Type: research

Oxidative balance score as predictor of all-cause, cancer, and noncancer mortality in a biracial US cohort.
CONCLUSIONS: These results suggest that individuals with a greater balance of antioxidant to pro-oxidant lifestyle exposures may have lower mortality. PMID: 25682727 [PubMed - as supplied by publisher]
Source: Annals of Epidemiology - January 16, 2015 Category: Epidemiology Authors: Kong SY, Goodman M, Judd S, Bostick RM, Flanders WD, McClellan W Tags: Ann Epidemiol Source Type: research

Antioxidant Vitamin Intake and Mortality: The Leisure World Cohort Study.
Abstract To assess the relationship between antioxidant vitamin intake and all-cause mortality in older adults, we examined these associations using data from the Leisure World Cohort Study, a prospective study of residents of the Leisure World retirement community in Laguna Hills, California. In the early 1980s, participants (who were aged 44-101 years) completed a postal survey, which included details on use of vitamin supplements and dietary intake of foods containing vitamins A and C. Age-adjusted and multivariate-adjusted (for factors related to mortality in this cohort-smoking, alcohol intake, caffeine consu...
Source: Am J Epidemiol - December 29, 2014 Category: Epidemiology Authors: Paganini-Hill A, Kawas CH, Corrada MM Tags: Am J Epidemiol Source Type: research