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Specialty: Internal Medicine
Source: Journal of Internal Medicine

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Total 67 results found since Jan 2013.

Potential health hazards of eating red meat
Abstract Red meat (beef, veal, pork, lamb and mutton) consumption contributes several important nutrients to the diet, for example essential amino acids, vitamins (including B12) and minerals (including iron and zinc). Processed red meat (ham, sausages, bacon, frankfurters, salami, etc.) undergoes treatment (curing, smoking, salting or the use of chemical preservatives and additives) to improve its shelf life and/or taste. During recent decades, consumption of red meat has been increasing globally, especially in developing countries. At the same time, there has been growing evidence that high consumption of red meat, espec...
Source: Journal of Internal Medicine - August 31, 2016 Category: Internal Medicine Authors: A. Wolk Tags: Review Source Type: research

Preadmission use of selective serotonin reuptake inhibitors and short ‐term mortality in diabetic patients hospitalized due to stroke
ConclusionIn patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.
Source: Journal of Internal Medicine - May 2, 2016 Category: Internal Medicine Authors: M. W ürtz, M. Schmidt, E. L. Grove, E. Horváth‐Puhó, C. F. Christiansen, H. T. Sørensen Tags: Original Article Source Type: research

Preadmission use of selective serotonin reuptake inhibitors and short‐term mortality in diabetic patients hospitalized due to stroke
ConclusionIn patients with diabetes, preadmission SSRI use was associated with increased mortality following ischaemic stroke, compared with nonuse.
Source: Journal of Internal Medicine - April 30, 2016 Category: Internal Medicine Authors: M. Würtz, M. Schmidt, E. L. Grove, E. Horváth‐Puhó, C. F. Christiansen, H. T. Sørensen Tags: Original Article Source Type: research

A tailored treatment strategy: a modern approach for stroke prevention in patients with atrial fibrillation
The objective of this review is to provide an overview of modern AF stroke prevention with a focus on tailored treatment strategies. Biomarkers and genetic factors have been proposed to help identify ‘high‐risk’ patients to be targeted for oral anticoagulation, but ultimately their use must be balanced against that of more simple and practical considerations for everyday use. Current guidelines have directed focus on initial identification of ‘truly low‐risk’ patients with AF, that is those patients with a CHA2DS2‐VASc [congestive heart failure, hypertension, age ≥75 years (two points), diabetes mellitus, ...
Source: Journal of Internal Medicine - March 21, 2016 Category: Internal Medicine Authors: G. Y. H. Lip, T. Potpara, G. Boriani, C. Blomström‐Lundqvist Tags: Review Source Type: research

Tailored treatment strategies: a new approach for modern management of atrial fibrillation
Abstract Atrial fibrillation (AF) is not benign. Cardiovascular diseases and risk factors differ importantly amongst patients. Careful phenotyping with the aim to start tailored therapy may improve outcome and quality of life. Furthermore, structural remodelling plays an important role in initiation and progression of AF. Therapies that interfere in the remodelling processes are promising because they may modify the atrial substrate. However, success is still limited probably due to variations in the underlying substrate in individual patients. The most favourable effects of lifestyle changes on success of rhythm control h...
Source: Journal of Internal Medicine - March 16, 2016 Category: Internal Medicine Authors: I. C. Gelder, A. H. Hobbelt, E. G. Marcos, U. Schotten, R. Cappato, T. Lewalter, J. Schwieler, M. Rienstra, G. Boriani Tags: Review Source Type: research

The glycocalyx and its significance in human medicine
Abstract Cells are covered by a surface layer of glycans that is referred to as the ‘glycocalyx’. In this review, we focus on the role of the glycocalyx in vascular diseases (atherosclerosis, stroke, hypertension, kidney disease and sepsis) and cancer. The glycocalyx and its principal glycosaminoglycans [heparan sulphate (HS) and hyaluronic acid (HA)] and core proteins (syndecans and glypicans) are degraded in vascular diseases, leading to a breakdown of the vascular permeability barrier, enhanced access of leucocytes to the arterial intima that propagate inflammation and alteration of endothelial mechanotransduction m...
Source: Journal of Internal Medicine - January 8, 2016 Category: Internal Medicine Authors: J. M. Tarbell, L. M. Cancel Tags: Review Source Type: research

Circulating calcium concentrations, vascular disease and mortality: a systematic review
Abstract Associations between serum calcium and vascular disease have been reported, but the consistency of these findings is unknown. We conducted a systematic review to determine whether circulating calcium concentrations are associated with risks of cardiovascular disease and death in normocalcaemic populations. We conducted PubMed searches up to 18 December 2014 and scrutinized reference lists of papers. Eligible studies related serum calcium to mortality or cardiovascular events in humans. A follow‐up of at least one year was required for longitudinal studies. Studies in populations selected on the basis of renal di...
Source: Journal of Internal Medicine - January 8, 2016 Category: Internal Medicine Authors: I. R. Reid, G. D. Gamble, M. J. Bolland Tags: Review Source Type: research

Gene expression signatures, pathways and networks in carotid atherosclerosis
ConclusionsOur findings confirmed a central role for inflammation and proteases in plaque instability, and highlighted haemoglobin metabolism and bone resorption as important pathways. Subgroup analysis suggested prolonged inflammation following the symptoms of plaque instability and calcification as a possible stabilizing mechanism by statins. In addition, transcriptional regulation may play an important role in the determination of plaque phenotype. The results from this study will serve as a basis for further exploration of molecular signatures in carotid atherosclerosis.
Source: Journal of Internal Medicine - December 1, 2015 Category: Internal Medicine Authors: L. Perisic, S. Aldi, Y. Sun, L. Folkersen, A. Razuvaev, J. Roy, M. Lengquist, S. Åkesson, C. E. Wheelock, L. Maegdefessel, A. Gabrielsen, J. Odeberg, G. K. Hansson, G. Paulsson‐Berne, U. Hedin Tags: Original Article Source Type: research

Alcohol and cardiovascular diseases: where do we stand today?
Abstract For centuries, multiple medical risks of heavy alcohol drinking have been evident with simultaneous awareness of a less harmful or sensible drinking limit. The increased risks of heavy drinking, defined as three or more standard‐sized drinks per day, are both cardiovascular (CV) and non‐CV. The CV risks include the following: (i) alcoholic cardiomyopathy (ACM), (ii) systemic hypertension, (iii) atrial arrhythmias, (iv) haemorrhagic stroke and, probably, ischaemic stroke. By contrast, modern epidemiological studies have shown lower morbidity and mortality amongst light–moderate drinkers, due mostly to a reduc...
Source: Journal of Internal Medicine - July 8, 2015 Category: Internal Medicine Authors: A. L. Klatsky Tags: Review Source Type: research

Role of exosomes and microvesicles in hypoxia‐associated tumour development and cardiovascular disease
Abstract Exosomes and microvesicles, collectively referred to as extracellular vesicles (EVs), can transfer complex biological information and induce a diverse signalling response in recipient cells with potential relevance in a wide array of pathological conditions. Tissue hypoxia constitutes a stress‐associated phenotype that is central to the malignant state of aggressive tumours as well as to ischaemic tissue in cardiovascular disorders. The adaptive response to hypoxic stress is largely dependent on intercellular communication in which EVs, and cellular exchange of EV cargo molecules, have recently been implicated. ...
Source: Journal of Internal Medicine - July 8, 2015 Category: Internal Medicine Authors: M. Belting, H. C. Christianson Tags: Review Source Type: research

Treatment of acute stroke: an update
Abstract Stroke is the second leading cause of global mortality after coronary heart disease, and a major cause of neurological disability. About 17 million strokes occur worldwide each year. Patients with stroke often require long‐term rehabilitation following the acute phase, with ongoing support from the community and nursing home care. Thus, stroke is a devastating disease and a major economic burden on society. In this overview, we discuss current strategies for specific treatment of stroke in the acute phase, focusing on intravenous thrombolysis and mechanical thrombectomy. We will consider two important issues re...
Source: Journal of Internal Medicine - July 1, 2015 Category: Internal Medicine Authors: R. Mikulik, N. Wahlgren Tags: Review Source Type: research

No association between adherence to the healthy Nordic food index and cardiovascular disease amongst Swedish women: a cohort study
ConclusionThe present results do not support an association between a healthy Nordic food index and risk of cardiovascular disease in Swedish women. There was also no effect modification by alcohol intake, BMI or age. Our finding of an interaction with smoking status requires reproduction.
Source: Journal of Internal Medicine - May 19, 2015 Category: Internal Medicine Authors: N. Roswall, S. Sandin, R. Scragg, M. Löf, G. Skeie, A. Olsen, H.‐O. Adami, E. Weiderpass Tags: Original Article Source Type: research

Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross‐sectional study
ConclusionsMeasures of atherosclerotic burden are associated with clinically manifest CVD in subjects with T2D. In addition, vascular changes that are not directly related to known metabolic risk factors are important in the development of both atherosclerosis and CVD in T2D. A better understanding of the mechanisms involved is crucial for enabling better identification of CVD risk in T2D.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - March 9, 2015 Category: Internal Medicine Authors: Angela C. Shore, Helen M. Colhoun, Andrea Natali, Carlo Palombo, Gerd Östling, Kunihiko Aizawa, Cecilia Kennbäck, Francesco Casanova, Margaretha Persson, Kim Gooding, Phillip E. Gates, Faisel Kahn, Helen C. Looker, Fiona Adams, Jill Belch, Silvia Pinnol Tags: Original Article Source Type: research

Choosing the right drug to fit the patient when selecting oral anticoagulation for stroke prevention in atrial fibrillation
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - March 1, 2015 Category: Internal Medicine Authors: Adrian M. Shields, Gregory Y. H. Lip Tags: Review Article Source Type: research

Symptomatic carotid near‐occlusion with full collapse might cause a very high risk of stroke
ConclusionsPatients with symptomatic carotid near‐occlusion with full collapse might have a very high risk of stroke recurrence. Carotid endarterectomy could be considered for these patients.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - October 1, 2014 Category: Internal Medicine Authors: Elias Johansson, Kjell Öhman, Per Wester Tags: Original Source Type: research