Gene expression signatures, pathways and networks in carotid atherosclerosis

ConclusionsOur findings confirmed a central role for inflammation and proteases in plaque instability, and highlighted haemoglobin metabolism and bone resorption as important pathways. Subgroup analysis suggested prolonged inflammation following the symptoms of plaque instability and calcification as a possible stabilizing mechanism by statins. In addition, transcriptional regulation may play an important role in the determination of plaque phenotype. The results from this study will serve as a basis for further exploration of molecular signatures in carotid atherosclerosis.

Source: Journal of Internal Medicine - December 1, 2015 Category: Internal Medicine Authors: L. Perisic, S. Aldi, Y. Sun, L. Folkersen, A. Razuvaev, J. Roy, M. Lengquist, S. Åkesson, C. E. Wheelock, L. Maegdefessel, A. Gabrielsen, J. Odeberg, G. K. Hansson, G. Paulsson‐Berne, U. Hedin Tags: Original Article Source Type: research