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Reply to “Important factors affecting the choice of an oral anticoagulant may be missed in database studies”
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 28, 2017 Category: Internal Medicine Authors: Anna Gundlund, Emil Loldrup Fosb øl, Jonas Bjerring Olesen Tags: Letter to the Editor Source Type: research

Outcomes of endovascular treatment for acute large ‐vessel ischaemic stroke more than 6 h after symptom onset
ConclusionsIn appropriately selected patients, EVT >6 h was associated with comparable outcomes to those treated <6 h. These data support a physiological approach to patient selection.
Source: Journal of Internal Medicine - September 25, 2017 Category: Internal Medicine Authors: R. Motyer, H. K. Kok, H. Asadi, A. O'Hare, P. Brennan, S. Power, S. Looby, P. Nicholson, D. Williams, S. Murphy, M. D. Hill, M. Goyal, J. McManus, P. O'Brien, J. Thornton Tags: Original Article Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.
Source: Journal of Internal Medicine - September 21, 2017 Category: Internal Medicine Authors: L. Staerk, T. A. Gerds, G. Y. H. Lip, B. Ozenne, A. N. Bonde, M. Lamberts, E. L. Fosb øl, C. Torp‐Pedersen, G. H. Gislason, J. B. Olesen Tags: Original Article Source Type: research

Important factors affecting the choice of an oral anticoagulant may be missed in database studies
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 7, 2017 Category: Internal Medicine Authors: Emma Aarnio, Risto Huupponen, Maarit Jaana Korhonen Tags: Letter to the Editor Source Type: research

Outcomes of endovascular treatment for acute large vessel ischemic stroke more than 6 hours after symptom onset
ConclusionsIn appropriately selected patients, EVT >6 hours was associated with comparable outcomes to those treated <6 hours. These data support a physiological approach to patient selection.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 5, 2017 Category: Internal Medicine Authors: Ronan Motyer, Hong Kuan Kok, Hamed Asadi, Alan O'Hare, Paul Brennan, Sarah Power, Seamus Looby, Patrick Nicholson, David Williams, Sean Murphy, Michael D. Hill, Mayank Goyal, John McManus, Paul O'Brien, John Thornton Tags: Original Article Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban, and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban, and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 1, 2017 Category: Internal Medicine Authors: Laila Staerk, Thomas A Gerds, Gregory Y H Lip, Brice Ozenne, Anders N Bonde, Morten Lamberts, Emil L Fosb øl, Christian Torp‐Pedersen, Gunnar H Gislason, Jonas B Olesen Tags: Original Article Source Type: research

Integrative studies implicate matrix metalloproteinase ‐12 as a culprit gene for large‐artery atherosclerotic stroke
ConclusionsOur study supports the notion that MMP12 is implicated in large‐artery atherosclerotic stroke, functionally by enhancing elastin degradation and macrophage invasion in plaques.
Source: Journal of Internal Medicine - August 28, 2017 Category: Internal Medicine Authors: H. Mahdessian, L. Perisic Matic, M. Lengquist, K. Gertow, B. Sennblad, D. Baldassarre, F. Veglia, S. E. Humphries, R. Rauramaa, U. Faire, A. J. Smit, P. Giral, S. Kurl, E. Mannarino, E. Tremoli, A. Hamsten, P. Eriksson, U. Hedin, A. M älarstig, Tags: Original Article Source Type: research

Plasma stem cell factor levels are associated with risk of cardiovascular disease and death
ConclusionsThis prospective population‐based study demonstrates that subjects with high levels of SCF have a lower risk of cardiovascular events and death. The findings provide clinical support for a protective role of SCF in maintaining cardiovascular integrity.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - August 26, 2017 Category: Internal Medicine Authors: Harry Bj örkbacka, Ingrid Yao Mattisson, Maria Wigren, Olle Melander, Gunilla Nordin Fredrikson, Eva Bengtsson, Isabel Gonçalves, Peter Almgren, Jens O. Lagerstedt, Marju Orho‐Melander, Gunnar Engström, Jan Nilsson Tags: Original Source Type: research

Integrative Studies Implicate Matrix Metalloproteinase 12 as a Culprit Gene for Large ‐Artery Atherosclerotic Stroke
ConclusionsOur study supports the notion that MMP12 is implicated in large‐artery atherosclerotic stroke, functionally by enhancing elastin degradation and macrophage invasion in plaques.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - July 22, 2017 Category: Internal Medicine Authors: Hovsep Mahdessian, Ljubica Perisic Matic, Mariette Lengquist, Karl Gertow, Bengt Sennblad, Damiano Baldassarre, Fabrizio Veglia, Steve E. Humphries, Rainer Rauramaa, Ulf Faire, Andries J. Smit, Philippe Giral, Sudhir Kurl, Elmo Mannarino, Elena Tremoli, A Tags: Original Article Source Type: research

Current evidence for endovascular therapy in stroke and remaining uncertainties (R1)
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - July 20, 2017 Category: Internal Medicine Authors: Ronan Motyer, Hamed Asadi, John Thornton, Patrick Nicholson, Hong Kuan Kok Tags: Review Source Type: research

Current evidence for endovascular therapy in stroke and remaining uncertainties
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - July 20, 2017 Category: Internal Medicine Authors: Ronan Motyer, Hamed Asadi, John Thornton, Patrick Nicholson, Hong Kuan Kok Tags: Review Source Type: research

Initiation of anticoagulation in atrial fibrillation: which factors are associated with choice of anticoagulant?
ConclusionsAF patients who were initiated on apixaban had higher stroke risk scores than patients initiated on VKAs. Interestingly, opposite results were found for dabigatranThis article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - May 8, 2017 Category: Internal Medicine Authors: Anna Gundlund, Laila Staerk, Emil Loldrup Fosb øl, Kasper Gadsboel, Caroline Sindet‐Pedersen, Anders Nissen Bonde, Gunnar H. Gislason, Jonas Bjerring Olesen Tags: Original Source Type: research

Management of acute ischaemic stroke in patients with dementia
Abstract An estimated 10% of stroke patients have an underlying dementia. As a consequence, health professionals often face the challenge of managing patients with dementia presenting with an acute stroke. Patients with dementia are less likely to receive thrombolysis (0.56–10% vs. 1–16% thrombolysis rates in the general population), be admitted to a stroke unit or receive some types of care. Anticoagulation for secondary stroke prevention is sometimes withheld, despite dementia not being listed as an exclusion criterion in current guidelines. Studies in this population are scarce, and results have been contradictory. ...
Source: Journal of Internal Medicine - February 1, 2017 Category: Internal Medicine Authors: A. Subic, P. Cermakova, B. Norrving, B. Winblad, M. Euler, M. G. Kramberger, M. Eriksdotter, S. Garcia ‐Ptacek Tags: Review Source Type: research

Glycaemic control and excess risk of ischaemic and haemorrhagic stroke in patients with type 1 diabetes: a cohort study of 33 453 patients
ConclusionsIndividuals with type 1 diabetes have an increased risk of ischaemic and haemorrhagic stroke, increasing markedly with poor glycaemic control.
Source: Journal of Internal Medicine - November 30, 2016 Category: Internal Medicine Authors: C. Hed én Ståhl, M. Lind, A.‐M. Svensson, S. Gudbjörnsdottir, A. Mårtensson, A. Rosengren Tags: Original Article Source Type: research

Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis
ConclusionThis phase II study showed that imatinib is safe and tolerable and may reduce neurological disability in patients treated with intravenous thrombolysis after ischaemic stroke. A confirmatory randomized trial is currently underway.
Source: Journal of Internal Medicine - October 31, 2016 Category: Internal Medicine Authors: N. Wahlgren, M. Thor én, B. Höjeberg, T.‐B. Käll, A.‐C. Laska, C. Sjöstrand, J. Höijer, H. Almqvist, S. Holmin, A. Lilja, L. Fredriksson, D. Lawrence, U. Eriksson, N. Ahmed Tags: Original Article Source Type: research

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