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Specialty: Internal Medicine
Source: Annals of Internal Medicine

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Total 404 results found since Jan 2013.

Treatments for Poststroke Motor Deficits and Mood Disorders: A Systematic Review for the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Guidelines for Stroke Rehabilitation.
Conclusion: Cardiorespiratory training, repetitive task training, and transcranial direct current stimulation may improve ADLs in adults with stroke. Cognitive behavioral therapy, exercise, and SSRIs may reduce symptoms of poststroke depression, but use of SSRIs to prevent depression or improve motor function was not supported. Primary Funding Source: U.S. Department of Veterans Affairs, Veterans Health Administration. PMID: 31739315 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - November 18, 2019 Category: Internal Medicine Authors: D'Anci KE, Uhl S, Oristaglio J, Sullivan N, Tsou AY Tags: Ann Intern Med Source Type: research

Pooled RCTs: In acute ischemic stroke with salvageable brain tissue, alteplase at 4.5 to 9 hours improved function.
PMID: 31610557 [PubMed - in process]
Source: Annals of Internal Medicine - October 14, 2019 Category: Internal Medicine Authors: Absher JR Tags: Ann Intern Med Source Type: research

Cases in Precision Medicine: A Personalized Approach to Stroke and Cardiovascular Risk Assessment in Women.
This article uses a case scenario to examine female sex-specific cardiovascular risk factors across the lifespan and describes a precision medicine-based approach to risk factor modification and primary prevention. It also presents recent updates to the role of genetic testing and polygenic risk scores for the prediction of stroke and cardiovascular disease. PMID: 31610550 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - October 14, 2019 Category: Internal Medicine Authors: Bello NA, Miller EC, Cleary KL, Wapner R Tags: Ann Intern Med Source Type: research

Rivaroxaban Versus Vitamin K Antagonist in Antiphospholipid Syndrome: A Randomized Noninferiority Trial.
Conclusion: Rivaroxaban did not show noninferiority to dose-adjusted VKAs for thrombotic APS and, in fact, showed a non-statistically significant near doubling of the risk for recurrent thrombosis. Primary Funding Source: Bayer Hispania. PMID: 31610549 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - October 14, 2019 Category: Internal Medicine Authors: Ordi-Ros J, Sáez-Comet L, Pérez-Conesa M, Vidal X, Riera-Mestre A, Castro-Salomó A, Cuquet-Pedragosa J, Ortiz-Santamaria V, Mauri-Plana M, Solé C, Cortés-Hernández J Tags: Ann Intern Med Source Type: research

Red and Processed Meat Consumption and Risk for All-Cause Mortality and Cardiometabolic Outcomes: A Systematic Review and Meta-analysis of Cohort Studies.
Conclusion: The magnitude of association between red and processed meat consumption and all-cause mortality and adverse cardiometabolic outcomes is very small, and the evidence is of low certainty. Primary Funding Source: None. (PROSPERO: CRD42017074074). PMID: 31569213 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 30, 2019 Category: Internal Medicine Authors: Zeraatkar D, Han MA, Guyatt GH, Vernooij RWM, El Dib R, Cheung K, Milio K, Zworth M, Bartoszko JJ, Valli C, Rabassa M, Lee Y, Zajac J, Prokop-Dorner A, Lo C, Bala MM, Alonso-Coello P, Hanna SE, Johnston BC Tags: Ann Intern Med Source Type: research

Patent Foramen Ovale and Ischemic Stroke in Patients With Pulmonary Embolism.
PMID: 31569246 [PubMed - in process]
Source: Annals of Internal Medicine - September 30, 2019 Category: Internal Medicine Authors: Le Moigne E, Jobic Y, Timsit S, Hoffmann C, Couturaud F Tags: Ann Intern Med Source Type: research

After stroke due to ICH while on antithrombotics, starting vs avoiding antiplatelets did not differ for symptomatic ICH.
PMID: 31525766 [PubMed - in process]
Source: Annals of Internal Medicine - September 16, 2019 Category: Internal Medicine Authors: Graham J Tags: Ann Intern Med Source Type: research

Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.
Conclusion: The effects of CEE did not differ by BSO status in the overall cohort, but some findings varied by age. Among women with prior BSO, in those aged 70 years or older, CEE led to adverse effects during the treatment period, whereas women randomly assigned to CEE before age 60 seemed to derive mortality benefit over the long term. Primary Funding Source: The WHI program is funded by the National Heart, Lung, and Blood Institute; National Institutes of Health; and U.S. Department of Health and Human Services. Wyeth Ayerst donated the study drugs. PMID: 31499528 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 9, 2019 Category: Internal Medicine Authors: Manson JE, Aragaki AK, Bassuk SS, Chlebowski RT, Anderson GL, Rossouw JE, Howard BV, Thomson CA, Stefanick ML, Kaunitz AM, Crandall CJ, Eaton CB, Henderson VW, Liu S, Luo J, Rohan T, Shadyab AH, Wells G, Wactawski-Wende J, Prentice RL, WHI Investigators Tags: Ann Intern Med Source Type: research

Midlife Smaller and Larger Infarctions, White Matter Hyperintensities, and 20-Year Cognitive Decline: A Cohort Study.
Conclusion: The substantial cognitive decline from middle age associated with having both smaller and larger infarctions, but not larger infarctions alone, suggests that the combination of smaller and larger infarctions may escalate risk for cognitive decline later in life in stroke-free persons. Primary Funding Source: National Institutes of Health. PMID: 31450238 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - August 26, 2019 Category: Internal Medicine Authors: Windham BG, Griswold ME, Wilkening SR, Su D, Tingle J, Coker LH, Knopman D, Gottesman RF, Shibata D, Mosley TH Tags: Ann Intern Med Source Type: research

Review: After stroke or TIA, adding clopidogrel to aspirin for ≤ 1 month reduces recurrence and MACE.
PMID: 31426057 [PubMed - in process]
Source: Annals of Internal Medicine - August 19, 2019 Category: Internal Medicine Authors: Hankey GJ Tags: Ann Intern Med Source Type: research

Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis.
Conclusion: In early-stage CKD, NOACs had a benefit-risk profile superior to that of VKAs. For advanced CKD or ESKD, there was insufficient evidence to establish benefits or harms of VKAs or NOACs. Primary Funding Source: None. (PROSPERO: CRD42017079709). PMID: 31307056 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 15, 2019 Category: Internal Medicine Authors: Ha JT, Neuen BL, Cheng LP, Jun M, Toyama T, Gallagher MP, Jardine MJ, Sood MM, Garg AX, Palmer SC, Mark PB, Wheeler DC, Jha V, Freedman B, Johnson DW, Perkovic V, Badve SV Tags: Ann Intern Med Source Type: research

Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map.
Conclusion: Reduced salt intake, omega-3 LC-PUFA use, and folate supplementation could reduce risk for some cardiovascular outcomes in adults. Combined calcium plus vitamin D might increase risk for stroke. Primary Funding Source: None. PMID: 31284304 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 8, 2019 Category: Internal Medicine Authors: Khan SU, Khan MU, Riaz H, Valavoor S, Zhao D, Vaughan L, Okunrintemi V, Riaz IB, Khan MS, Kaluski E, Murad MH, Blaha MJ, Guallar E, Michos ED Tags: Ann Intern Med Source Type: research

In AF, ABC scores predicted stroke or major bleeding better than CHA2DS2-VASc and HAS-BLED scores, respectively.
PMID: 31207624 [PubMed - in process]
Source: Annals of Internal Medicine - June 17, 2019 Category: Internal Medicine Authors: Kearon C Tags: Ann Intern Med Source Type: research

Cardiovascular Events and Mortality in White Coat Hypertension: A Systematic Review and Meta-analysis.
Conclusion: Untreated WCH, but not treated WCE, is associated with an increased risk for cardiovascular events and all-cause mortality. Out-of-office BP monitoring is critical in the diagnosis and management of hypertension. Primary Funding Source: National Institutes of Health. PMID: 31181575 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - June 10, 2019 Category: Internal Medicine Authors: Cohen JB, Lotito MJ, Trivedi UK, Denker MG, Cohen DL, Townsend RR Tags: Ann Intern Med Source Type: research