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Specialty: Internal Medicine
Source: Annals of Internal Medicine

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Total 404 results found since Jan 2013.

In imaging-selected ischemic stroke with unknown onset, alteplase increases favorable outcomes and death at 90 d
Ann Intern Med. 2021 Apr 6. doi: 10.7326/ACPJ202104200-042. Online ahead of print.ABSTRACTThomalla G, Boutitie F, Ma H, et al. Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data. Lancet. 2020;396:1574-84. 33176180.PMID:33819060 | DOI:10.7326/ACPJ202104200-042
Source: Annals of Internal Medicine - April 5, 2021 Category: Internal Medicine Authors: Michael D Hill Source Type: research

Effectiveness and Safety of Direct Oral Anticoagulants Versus Warfarin in Patients With Valvular Atrial Fibrillation : A Population-Based Cohort Study
CONCLUSION: In this comparative effectiveness study using practice-based claims data, patients with valvular AF who were new users of DOACs had lower risks for ischemic stroke or systemic embolism and major bleeding than new users of warfarin. These data may be used to guide risk-benefit discussions regarding anticoagulant choices for patients with valvular AF.PRIMARY FUNDING SOURCE: None.PMID:33780291 | DOI:10.7326/M20-6194
Source: Annals of Internal Medicine - March 29, 2021 Category: Internal Medicine Authors: Ghadeer K Dawwas Eric Dietrich Adam Cuker Geoffrey D Barnes Charles E Leonard James D Lewis Source Type: research

In older patients with AF, low-dose edoxaban reduced stroke or systemic embolism without increasing major bleeding.
Abstract SOURCE CITATION: Okumura K, Akao M, Yoshida T, et al. Low-dose edoxaban in very elderly patients with atrial fibrillation. N Engl J Med. 2020;383:1735-45. 32865374. PMID: 33395333 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - January 5, 2021 Category: Internal Medicine Authors: Steinberg DI Tags: Ann Intern Med Source Type: research

In acute ischemic stroke or TIA, adding ticagrelor to aspirin reduced stroke or death and increased severe bleeding.
Abstract SOURCE CITATION: Johnston SC, Amarenco P, Denison H, et al. Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA. N Engl J Med. 2020;383:207-17. 32668111. PMID: 33316187 [PubMed - in process]
Source: Annals of Internal Medicine - December 15, 2020 Category: Internal Medicine Authors: Hill MD Tags: Ann Intern Med Source Type: research

Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence.
PMID: 33253619 [PubMed - in process]
Source: Annals of Internal Medicine - December 1, 2020 Category: Internal Medicine Authors: Aggarwal G, Aggarwal S, Cohen M Tags: Ann Intern Med Source Type: research

In established atherosclerosis, P2Y12 inhibitor vs. aspirin monotherapy reduces MI but not stroke or mortality.
Abstract SOURCE CITATION: Chiarito M, Sanz-Sánchez J, Cannata F, et al. Monotherapy with a P2Y12 inhibitor or aspirin for secondary prevention in patients with established atherosclerosis: a systematic review and meta-analysis. Lancet. 2020;395;1487-95. 32386592. PMID: 32926821 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 14, 2020 Category: Internal Medicine Authors: Elgendy IY Tags: Ann Intern Med Source Type: research

In ischemic stroke, thrombectomy alone was noninferior to thrombectomy plus alteplase for functional outcome at 90 days.
Abstract SOURCE CITATION: Yang P, Zhang Y, Zhang L, et al. Endovascular thrombectomy with or without intravenous alteplase in acute stroke. N Engl J Med. 2020;382:1981-93. 32374959. PMID: 32926812 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 14, 2020 Category: Internal Medicine Authors: Alberts MJ Tags: Ann Intern Med Source Type: research

Effect of Intensive Blood Pressure Lowering on Cardiovascular Outcomes: A Systematic Review Prepared for the 2020 U.S. Department of Veterans Affairs/U.S. Department of Defense Guidelines.
CONCLUSION: Overall, current clinical literature supports intensive BP lowering in patients with hypertension for improving cardiovascular outcomes. In most subpopulations, intensive lowering was favored over less-intensive lowering, but the data were less clear for patients with diabetes mellitus or cardiovascular disease. PRIMARY FUNDING SOURCE: U.S. Department of Veterans Affairs, Veterans Health Administration. PMID: 32866419 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - August 31, 2020 Category: Internal Medicine Authors: D'Anci KE, Tipton K, Hedden-Gross A, Rouse B, Hermanson L, Fontanarosa J Tags: Ann Intern Med Source Type: research