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Specialty: Internal Medicine
Source: Annals of Internal Medicine

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Total 404 results found since Jan 2013.

Age- and Weight-Adapted Dose of Prasugrel Versus Standard Dose of Ticagrelor in Patients With Acute Coronary Syndromes: Results From a Randomized Trial.
CONCLUSION: In elderly or low-weight patients with ACS, a reduced dose of prasugrel compared with the standard dose of ticagrelor is associated with maintained anti-ischemic efficacy while protecting these patients against the excess risk for bleeding. PRIMARY FUNDING SOURCE: German Center for Cardiovascular Research and Deutsches Herzzentrum München. PMID: 32687741 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - July 20, 2020 Category: Internal Medicine Authors: Menichelli M, Neumann FJ, Ndrepepa G, Mayer K, Wöhrle J, Bernlochner I, Richardt G, Witzenbichler B, Sibbing D, Gewalt S, Angiolillo DJ, Lahu S, Hamm CW, Hapfelmeier A, Trenk D, Laugwitz KL, Schunkert H, Schüpke S, Kastrati A Tags: Ann Intern Med Source Type: research

Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes: A Systematic Review and Network Meta-analysis.
CONCLUSION: In diabetic patients at low cardiovascular risk, no treatment differs from placebo for vascular outcomes. In patients at increased cardiovascular risk receiving metformin-based background therapy, specific GLP-1 RAs and SGLT-2 inhibitors have a favorable effect on certain cardiovascular outcomes. PRIMARY FUNDING SOURCE: European Foundation for the Study of Diabetes, supported by an unrestricted educational grant from AstraZeneca. (PROSPERO: CRD42019122043). PMID: 32598218 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - June 29, 2020 Category: Internal Medicine Authors: Tsapas A, Avgerinos I, Karagiannis T, Malandris K, Manolopoulos A, Andreadis P, Liakos A, Matthews DR, Bekiari E Tags: Ann Intern Med Source Type: research

In ischemic stroke with viable hypoperfused tissue, alteplase >  4.5 h after last seen well improves function.
In ischemic stroke with viable hypoperfused tissue, alteplase > 4.5 h after last seen well improves function. Ann Intern Med. 2020 May 19;172(10):JC50 Authors: Hill MD Abstract SOURCE CITATION: Tsivgoulis G, Katsanos AH, Malhotra K, et al. Thrombolysis for acute ischemic stroke in the unwitnessed or extended therapeutic time window. Neurology. 2020;94:e1241-8. 31892636. PMID: 32422094 [PubMed - in process]
Source: Annals of Internal Medicine - May 18, 2020 Category: Internal Medicine Authors: Hill MD Tags: Ann Intern Med Source Type: research

In older adults with acute ischemic stroke, the Clinical Frailty Scale predicted mortality at 28 days.
Abstract SOURCE CITATION: Evans NR, Wall J, To B, et al. Clinical frailty independently predicts early mortality after ischaemic stroke. Age Ageing. 2020. [Epub ahead of print]. 31951248. PMID: 32422086 [PubMed - in process]
Source: Annals of Internal Medicine - May 18, 2020 Category: Internal Medicine Authors: Hirsch C Tags: Ann Intern Med Source Type: research

Residual Shunt After Patent Foramen Ovale Closure and Long-Term Stroke Recurrence.
CONCLUSION: Among patients undergoing PFO closure to prevent future stroke, the presence of residual shunt, particularly a moderate or large residual shunt, was associated with an increased risk for stroke or TIA recurrence. PRIMARY FUNDING SOURCE: National Institutes of Health. PMID: 32422058 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - May 11, 2020 Category: Internal Medicine Authors: Deng W, Yin S, McMullin D, Inglessis-Azuaje I, Elmariah S, Hung J, Lo EH, Palacios IF, Buonanno FS, Ning M Tags: Ann Intern Med Source Type: research

Isradipine Versus Placebo in Early Parkinson Disease: A Randomized Trial.
Conclusion: Long-term treatment with immediate-release isradipine did not slow the clinical progression of early-stage PD. Primary Funding Source: National Institute of Neurological Disorders and Stroke. PMID: 32227247 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - March 30, 2020 Category: Internal Medicine Authors: Parkinson Study Group STEADY-PD III Investigators Tags: Ann Intern Med Source Type: research

Dual Versus Triple Therapy for Atrial Fibrillation After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis.
Conclusion: In adults with AF after PCI, dual therapy reduces risk for bleeding compared with triple therapy, whereas its effects on risks for death and ischemic end points are still unclear. Primary Funding Source: None. PMID: 32176890 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - March 16, 2020 Category: Internal Medicine Authors: Khan SU, Osman M, Khan MU, Khan MS, Zhao D, Mamas MA, Savji N, Al-Abdouh A, Hasan RK, Michos ED Tags: Ann Intern Med Source Type: research

Effectiveness and Safety of Apixaban Compared With Rivaroxaban for Patients With Atrial Fibrillation in Routine Practice: A Cohort Study.
Conclusion: In routine care, adults with atrial fibrillation prescribed apixaban had a lower rate of both ischemic stroke or systemic embolism and bleeding compared with those prescribed rivaroxaban. Primary Funding Source: Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital. PMID: 32150751 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - March 9, 2020 Category: Internal Medicine Authors: Fralick M, Colacci M, Schneeweiss S, Huybrechts KF, Lin KJ, Gagne JJ Tags: Ann Intern Med Source Type: research

In ACS with planned invasive evaluation, prasugrel vs ticagrelor reduced a composite of death, MI, or stroke at 1 y.
PMID: 31958819 [PubMed - in process]
Source: Annals of Internal Medicine - January 20, 2020 Category: Internal Medicine Authors: Raco DL Tags: Ann Intern Med Source Type: research

In acute ischemic stroke with hyperglycemia, intensive vs standard glucose control did not improve 90-day outcomes.
PMID: 31842225 [PubMed - in process]
Source: Annals of Internal Medicine - December 16, 2019 Category: Internal Medicine Authors: Alberts MJ Tags: Ann Intern Med Source Type: research

In acute ischemic stroke with potentially salvageable tissue, thrombectomy at 6 to 16 h increased living at home.
PMID: 31842224 [PubMed - in process]
Source: Annals of Internal Medicine - December 16, 2019 Category: Internal Medicine Authors: Hankey GJ Tags: Ann Intern Med Source Type: research

Should This Patient Be Screened for Atrial Fibrillation?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2019 Dec 03;171(11):828-836 Authors: Burns RB, Zimetbaum P, Lubitz SA, Smetana GW Abstract Atrial fibrillation (AFib) is the most common type of cardiac arrhythmia, affecting 2.7 million to 6.1 million persons in the United States. Although some persons with AFib have no symptoms, others do. For those without symptoms, AFib may be detected by 12-lead electrocardiogram (ECG), single-lead monitors (such as ambulatory blood pressure monitors and pulse oximeters), or consumer devices (such as wearable monitors and smartphones). Pulse pa...
Source: Annals of Internal Medicine - December 2, 2019 Category: Internal Medicine Authors: Burns RB, Zimetbaum P, Lubitz SA, Smetana GW Tags: Ann Intern Med Source Type: research

Altered Risk for Cardiovascular Events With Changes in the Metabolic Syndrome Status: A Nationwide Population-Based Study of Approximately 10 Million Persons.
Conclusion: Recovery from MetS was significantly associated with decreased risk for MACE, whereas development of MetS was associated with increased risk. Primary Funding Source: Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea. PMID: 31766057 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - November 25, 2019 Category: Internal Medicine Authors: Park S, Lee S, Kim Y, Lee Y, Kang MW, Han K, Han SS, Lee H, Lee JP, Joo KW, Lim CS, Kim YS, Kim DK Tags: Ann Intern Med Source Type: research

Review: In dyslipidemia or atherosclerotic CVD, alirocumab and evolocumab vs control each reduce MI and stroke.
PMID: 31739339 [PubMed - in process]
Source: Annals of Internal Medicine - November 18, 2019 Category: Internal Medicine Authors: Smith DA Tags: Ann Intern Med Source Type: research

The Management of Stroke Rehabilitation: A Synopsis of the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.
Abstract Description: In June 2019, the U.S. Department of Veterans Affairs (VA) and U.S. Department of Defense (DoD) approved an update of the joint clinical practice guideline for rehabilitation after stroke. This synopsis summarizes the key recommendations from this guideline. Methods: In February 2018, the VA/DoD Evidence-Based Practice Work Group convened a joint VA/DoD guideline development effort that included clinical stakeholders and stroke survivors and conformed to the National Academy of Medicine (formerly the Institute of Medicine) tenets for trustworthy clinical practice guidelines. The guidelin...
Source: Annals of Internal Medicine - November 18, 2019 Category: Internal Medicine Authors: Sall J, Eapen BC, Tran JE, Bowles AO, Bursaw A, Rodgers ME Tags: Ann Intern Med Source Type: research