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Fixed-Dose Combination Therapy for Prevention of Cardiovascular Diseases in CKD: An Individual Participant Data Meta-analysis
CONCLUSIONS: A fixed-dose combination treatment strategy is effective and safe at preventing cardiovascular disease, irrespective of eGFR but relative and absolute risk reductions are larger in individuals with low eGFR.PMID:37550842 | DOI:10.2215/CJN.0000000000000251
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 8, 2023 Category: Urology & Nephrology Authors: Sadaf G Sepanlou Johannes F E Mann Philip Joseph Prem Pais Peggy Gao Maryam Sharafkhah Gholamreza Roshandel Salim Yusuf Reza Malekzadeh Source Type: research

in this issue
Aspirin (ASA) has been postulated to improve cardiovascular outcomes in at-risk individuals, although the extent of protection remains controversial. The effect of ASA on cardiovascular outcomes in patients with chronic kidney disease (CKD) was examined in The International Polycap Study-3 (TIPS-3). Patients were treated with low-dose ASA (75 mg/d) or placebo and stratified by estimated glomerular filtration rate (eGFR). The investigators looked at a composite outcome of nonfatal myocardial infarction, nonfatal stroke, and cardiac death.
Source: Kidney International - January 19, 2023 Category: Urology & Nephrology Tags: In This Issue Source Type: research

Post Hoc Analyses of Randomized Clinical Trial for the Effect of Clopidogrel Added to Aspirin on Kidney Function.
CONCLUSIONS: We found no effect of clopidogrel added to aspirin compared with aspirin alone on kidney function decline among persons with prior lacunar stroke. PMID: 28446537 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - April 26, 2017 Category: Urology & Nephrology Authors: Ikeme JC, Pergola PE, Scherzer R, Shlipak MG, Benavente OR, Peralta CA Tags: Clin J Am Soc Nephrol Source Type: research

Antiplatelet agents in hemodialysis.
In conclusion, since CRF patients are one of the groups at highest risk for atherosclerotic events, it could be reasonable to use aspirin in HD patients. However, the bleeding risk in HD patients needs to be strongly evaluated, especially before starting dual AA treatment. PMID: 27928736 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - December 7, 2016 Category: Urology & Nephrology Authors: Migliori M, Cantaluppi V, Scatena A, Panichi V Tags: J Nephrol Source Type: research

Long-term versus short-term dual antiplatelet therapy was similarly associated with a lower risk of death, stroke, or infarction in patients with acute coronary syndrome regardless of underlying kidney disease
Scarce and conflicting evidence exists on whether clopidogrel is effective and whether dual antiplatelet treatment (DAPT) is safe in patients with acute coronary syndrome and chronic kidney disease (CKD). To study this, we performed an observational, prospective, multicenter cohort study of 36,001 patients of the SWEDEHEART registry. The exposure was DAPT prolonged after 3 months versus DAPT stopped at 3 months in consecutive patients with acute coronary syndrome and known serum creatinine. DAPT duration with clopidogrel and aspirin was assessed by dispensed tablets.
Source: Kidney International - November 15, 2016 Category: Urology & Nephrology Authors: Juan-Jesus Carrero, Christoph Varenhorst, Karin Jensevik, Karolina Szummer, Bo Lagerqvist, Marie Evans, Jonas Spaak, Claes Held, Stefan James, Tomas Jernberg Tags: Clinical Investigation Source Type: research

Perioperative Aspirin and Clonidine and Risk of Acute Kidney Injury
In this sub-study of the POISE-2 study, neither ASA or clonidine reduced the risk of acute kidney injury after non-cardiac surgery. Of note, aspirin increased the risk of major bleeding (which was associated with a greater risk of acute kidney injury).  As well, clonidine increased the risk of clinically important hypotension (which was associated with a greater risk of acute kidney injury). : Stroke and Bleeding in Atrial Fibrillation with Chronic Kidney Disease Risk of acute kidney injury associated with the use of fluoroquinolones Chronic Dialysis and Death Among Survivors of Acute Kidney Injury Requiring Dialysis
Source: Nephrology Now - November 16, 2014 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Source Type: research

Hypertension care in Aseer region, Saudi Arabia: Barriers and solutions.
This study revealed that HTN patients received insufficient care, which could be attributed to many different barriers. In order to improve the quality of HTN care for HTN, these barriers should be overcome by implementation of the recommendations. PMID: 25394461 [PubMed - in process]
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Al-Saleem SA, Al-Shahrani A, Al-Khaldi YM Tags: Saudi J Kidney Dis Transpl Source Type: research

Evidence for the Prevention and Treatment of Stroke in Dialysis Patients.
Abstract The risks of both ischemic and hemorrhagic stroke are particularly high in dialysis patients of any age and outcomes are poor. It is therefore important to identify strategies that safely minimize stroke risk in this population. Observational studies have been unable to clarify the relative importance of traditional stroke risk factors such as blood pressure and cholesterol in those on dialysis, and are affected by biases that usually make them an inappropriate source of data on which to base therapeutic decisions. Well-conducted randomized trials are not susceptible to such biases and can reliably invest...
Source: Seminars in Dialysis - July 7, 2014 Category: Urology & Nephrology Authors: Herrington W, Haynes R, Staplin N, Emberson J, Baigent C, Landray M Tags: Semin Dial Source Type: research

Antiplatelet therapy for preventing stroke in patients with chronic kidney disease.
Abstract Chronic kidney disease (CKD), defined as reduced glomerular filtration rate and/or proteinuria, is a serious worldwide health problem. The incidence and prevalence of CKD are increasing with age, and patients with CKD are a population at very high risk for developing stroke. CKD may increase the risk for incident stroke independent of conventional stroke risk factors. A common pathological process including anemia, homocysteine, nitric oxide, oxidative stress, inflammation, and conditions promoting coagulation may be related to the development of stroke in the course of CKD. CKD can also serve as a marker...
Source: Contributions to Nephrology - May 26, 2013 Category: Urology & Nephrology Authors: Kim SJ, Bang OY Tags: Contrib Nephrol Source Type: research