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Total 51210 results found since Jan 2013.
Protein kinase D2 confers neuroprotection by promoting AKT and CREB activation in ischemic stroke
In this study, we found that PKD2 expression and activity were significantly upregulated in the ipsilateral side of the brain after transient focal cerebral ischemia, which coincides with the upregulation of PKD2 in primary neurons in response to in vitro ischemia, implying a potential role of PKD2 in neuronal survival in ischemic stroke. Using kinase-dead PKD2 knock-in (PKD2-KI) mice, we examined whether loss of PKD2 activity affected stroke outcomes in mice subjected to 1 h of transient middle cerebral artery occlusion (tMCAO) and 24 h of reperfusion. Our data demonstrated that PKD2-KI mice exhibited larger infarction vo...
Source: Neurobiology of Disease - September 20, 2023 Category: Neurology Authors: Jaclyn A Connelly Xuejing Zhang Yuzhou Chen Yapeng Chao Yejie Shi Tija C Jacob Q Jane Wang Source Type: research
Table of Contents
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Source Type: research
Editorial Board
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Source Type: research
Masthead
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Source Type: research
Low value of inherited thrombophilia testing among patients with stroke or transient ischemic attack: A three-year retrospective study
Inherited thrombophilia testing in the acute inpatient setting is controversial and expensive, and rarely changes clinical management. We evaluated ordering patterns and results of inpatient inherited thrombophilia testing for patients who presented with an isolated acute ischemic stroke or transient ischemic attack (TIA) without concurrent venous thromboembolism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Shyam Majmundar, Sameep Thapa, Elan S. Miller, Rodney Bell, Robin Dharia, Diana Tzeng, Shaista Alam, Ruben Rhoades Source Type: research
Organized multi-disciplinary stroke team care improves acute stroke outcomes in resource limited settings; Results of a retrospective study from a Nigerian tertiary hospital
Evidence for the impact of organized stroke multidisciplinary teams (MDTs) on outcomes in Africa is sparse.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Olaleye Adeniji, Osi Adeleye, Joshua Akinyemi, Folajimi Otubogun, Gabriel Ogunde, Mayowa Ogunrombi, Deborah Adesina, Ahmed Wahab, Michael Ogunlana, Talayo Alimi, Rufus Akinyemi Source Type: research
Mediterranean-style diet and intracranial large artery stenosis in the Northern Manhattan Study
Intracranial large artery stenosis (ICAS) is one of the most common causes of stroke worldwide.1 Among stroke-free community-dwelling adults, ICAS is prevalent, associated with modifiable vascular risk factors, and confers risk of incident vascular events.2 Given prior work linking a Mediterranean-style diet (MeDi), which is rich in fruits, vegetables, fish, whole grains, legumes, and nuts, to reduced risk of vascular conditions and cardiovascular events,3,4 we hypothesized MeDi may also be protective against ICAS.
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Dixon Yang, Hannah Gardener, Farid Khasiyev, Tatjana Rundek, Clinton B Wright, Mitchell SV Elkind, Jose Gutierrez Source Type: research
Gait analysis patterns and rehabilitative interventions to improve gait in persons with hereditary spastic paraplegia: a systematic review and meta-analysis
ConclusionKnee hyperextension, non-sagittal pelvic movements, and reduced ROM at the knee, ankle, and hip represent the most peculiar patterns in HSP, compared to diplegic cerebral palsy and stroke. Botulinum improved comfortable gait velocity after 2 months. Nonetheless, interventions reducing spasticity might result in ineffective functional outcomes unveiling weakness. Intensive active physical therapy and FES might improve gait velocity in the very short term.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research
Cerebral artery signal intensity gradient from Time-of-Flight Magnetic Resonance Angiography and clinical outcome in lenticulostriate infarction: a retrospective cohort study
ConclusionCerebral artery SIG from TOF-MRA was significantly associated with short-term functional outcomes in patients with lenticulostriate infarction. Further studies are needed to investigate the temporal relationships of SIG in patients with cerebral infarction.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research
In reply to the Letter to the Editor regarding: Identifying large vessel occlusion using the hyperdense artery sign in patients treated with mechanical thrombectomy
We sincerely thank Drs. Shunji Mugikura and Naoko Mori for the interest and comments in our article, “Identifying large vessel occlusion using the hyperdense artery sign in patients treated with mechanical thrombectomy”.1
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Takuya Saito, Ryo Itabashi, Kazutaka Uchida, Yuichi Kawabata, Shota Igasaki, Kazuhiko Sato, Tomohiro Chiba, Takeshi Morimoto, Yukako Yazawa Tags: Letter to the Editor Source Type: research
Before juvenile stroke can be attributed to MYH11 variants, alternative etiologies and pathophysiologies must be adequately ruled out
We read with interest the article by Raghuram et al. on a 12 year-old female who developed severe ischemic stroke (NIHSS 16) due to right proximal middle cerebral artery (MCA) occlusion [1]. Despite thrombolysis and thrombectomy, the patient's recovery was incomplete [1]. The cause of the occlusion was attributed to a focal dissection of the MCA due to the variant IVS32G>A in MYH11, which was also found in the maternal grandmother, mother, older sister, and a maternal cousin, two of whom had aortic dissection in the past [1].
Source: Journal of Stroke and Cerebrovascular Diseases - September 20, 2023 Category: Neurology Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
A nomogram predicts early neurological deterioration after mechanical thrombectomy in patients with ischemic stroke
DiscussionOur study established and validated a nomogram to stratify the risk of END before mechanical embolectomy and identify high-risk patients, who should be more cautious when making clinical decisions.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research
Case report: Retrograde endovascular recanalization of vertebral artery occlusion with non-tapered stump via the deep cervical collateral
ConclusionAntegrade endovascular recanalization of VA occlusion with a non-tapered stump is a challenge. The retrograde endovascular method via the cervical collateral may be an alternative for this type of VA occlusion, which requires further exploration.
Source: Frontiers in Neurology - September 20, 2023 Category: Neurology Source Type: research
Pure Sensory Lacunar Infarction in the Thalamus Presented as Bilateral Hypogeusia: A Case Report
CONCLUSION: The exact gustatory pathway in humans remains uncertain nowadays. First, there were few reports about dysgeusia, which might be related to clinical neglect of taste deficits. Second, our knowledge of the human gustatory pathway depends solely on sporadic cases of taste-involved brain lesions. We reported a case of bilateral hypogeusia after right thalamic infarction. This finding indicates that, although there might be laterality of gustatory fibers to the left hemisphere, anatomical variations may exist in the human gustatory system. More research is needed to elucidate the understanding of the gustatory pathw...
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Yu-Chun Wang I-Hsu Chen Poyin Huang Source Type: research
First-Ever Ischemic Stroke In Covid-19: How Is It Different? - A Stroke Registry-Based Study From South India
Acta Neurol Taiwan. 2023 Dec 30;32(4):190-201.ABSTRACTStroke associated with COVID-19 has been characterised in several multicentre retrospective studies and meta-analyses. However, they did not distinguish first-ever ischemic strokes (F-AIS). Therefore, we aimed to study the incidence, clinical characteristics, and outcomes of a cohort of F-AIS associated with COVID-19 during the first wave of the pandemic and compare this cohort with those of F-AIS without COVID-19, COVID-19 without stroke. We also sought to compare the stroke admissions and mechanisms during the pandemic and immediate prepandemic periods.PMID:37723911
Source: Acta Neurologica Taiwanica - September 19, 2023 Category: Neurology Authors: Muralidhar Reddy Y Jagarlapudi Mk Murthy Sreekanth Reddy Y Abhinay Kumar Gattu Shyam K Jaiswal Lalitha Pidaparthi Subhendu Parida Santhosh Kumar B Syed Osman Shanti Naidu Kamatam Source Type: research
