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Nutrition: Iron

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Total 75 results found since Jan 2013.

Association of Ferroptosis with Severity and Outcomes in Acute Ischemic Stroke Patients Undergoing Endovascular Thrombectomy: A Case-control Study
AbstractFerroptosis, an iron-dependent form of cell death, is characterized by intracellular accumulation of iron and reactive oxygen species-induced lipid peroxidation. Animal experiments have shown the important roles of ferroptosis in ischemic stroke, but the evidence in human stroke is insufficient. This prospective study evaluated the associations between plasma ferroptosis biomarkers at hyperacute stage and long-term outcomes in patients with acute ischemic stroke undergoing endovascular thrombectomy (EVT). The plasma samples were collected immediately before and after EVT (T1 and T2) and at 24  h (T3) for the 126 s...
Source: Molecular Neurobiology - September 7, 2023 Category: Neurology Source Type: research

Cottonseed oil alleviates ischemic stroke injury by inhibiting ferroptosis
ConclusionCSO treatment can alleviate ischemic stroke injury via ferroptosis inhibition, which provides a new potential therapeutic mechanism for CSO neuroprotection against ischemic stroke.
Source: Brain and Behavior - July 22, 2023 Category: Neurology Authors: Miao Sun, Min Liu, Qingxiao Li, Xiaoying Zhang, Siyuan Liu, Huikai Yang, Le Yang, Jiahe Tian, Weidong Mi, Yulong Ma Tags: ORIGINAL ARTICLE Source Type: research

A bibliometric analysis of cerebral microbleeds and cognitive impairment
CONCLUSION: This bibliometric analysis reveals a strong link between CMBs and cognitive impairment-related diseases and that specific brain networks were affected by CMBs. This provides further insights into the possible mechanisms and causes of CMBs and cognitive impairment. The direct and indirect damage (such as oxidative stress and neuroinflammation) to the brain caused by CMBs, destruction of the frontal-subcortical circuits, elevated Cystatin C levels, and iron deposition are involved in the occurrence and development of cognitive impairment. CMBs may be a potential marker for detecting, quantifying, and predicting c...
Source: Brain and Cognition - June 1, 2023 Category: Neurology Authors: Rui Yang Jia Li Yaya Qin Li Zhao Rong Liu Fanhui Yang Guohui Jiang Source Type: research

Epigenetic Regulation of Ferroptosis in Central Nervous System Diseases
AbstractFerroptosis, a newly identified form of cell death, is characterized by iron overload and accumulation of lipid reactive oxygen species. Inactivation of pathways, such as glutathione/glutathione peroxidase 4, NAD(P)H/ferroptosis suppressor protein 1/ubiquinone, dihydroorotate dehydrogenase/ubiquinol, or guanosine triphosphate cyclohydrolase-1/6(R)-l-erythro-5,6,7,8-tetrahydrobiopterin pathways, have been found to induce ferroptosis. The accumulating data suggest that epigenetic regulation can determine cell sensitivity to ferroptosis at both the transcriptional and translational levels. While many of the effectors ...
Source: Molecular Neurobiology - May 28, 2023 Category: Neurology Source Type: research

Role of lipocalin 2 in stroke
Neurobiol Dis. 2023 Feb 16:106044. doi: 10.1016/j.nbd.2023.106044. Online ahead of print.ABSTRACTStroke is the second leading cause of death worldwide; however, the treatment choices available to neurologists are limited in clinical practice. Lipocalin 2 (LCN2) is a secreted protein, belonging to the lipocalin superfamily, with multiple biological functions in mediating innate immune response, inflammatory response, iron-homeostasis, cell migration and differentiation, energy metabolism, and other processes in the body. LCN2 is expressed at low levels in the brain under normal physiological conditions, but its expression i...
Source: Neurobiology of Disease - February 22, 2023 Category: Neurology Authors: Ruo-Yu Zhao Peng-Ju Wei Xin Sun Dian-Hui Zhang Qian-Yan He Jie Liu Jun-Lei Chang Yi Yang Zhen-Ni Guo Source Type: research

TUK9Ferrostatin-1 alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3 β signaling pathway
In conclusion, Fer-1 has protective effects on cerebral I/R injury by activating the AKT/GSK3β pathway, indicating that ferroptosis may become a novel target in the treatment of ischemic stroke.PMID:36596364 | DOI:10.1016/j.brainresbull.2022.12.009
Source: Brain Research - January 3, 2023 Category: Neurology Authors: Xinyao Liu Yue Du Jian Liu Linggang Cheng Wen He Wei Zhang Source Type: research

SATB1/SLC7A11/HO-1 Axis Ameliorates Ferroptosis in Neuron Cells After Ischemic Stroke by Danhong Injection
AbstractNeuronal damage after ischemic stroke (IS) is frequently due to ferroptosis, contributing significantly to ischemic injury. However, the mechanism against ferroptosis in IS remained unclear. The aim of this study was to investigate the potential mechanism of Danhong injection (DHI) and the critical transcription factor SATB1 in preventing neuronal ferroptosis after ischemic stroke in vivo and in vitro. The results showed that DHI treatment significantly reduced the infarct area and associated damage in the brains of the pMCAO mice, and enhanced the viability of OGD-injured neurons. And several characteristic indica...
Source: Molecular Neurobiology - December 17, 2022 Category: Neurology Source Type: research

Effects of Hyperferritinemia on Functional Outcome in Acute Ischemic Stroke Patients with Admission Hyperglycemia
Conclusions: High iron status, presented as hyperferritinemia, is associated with poor 3-month functional outcome in AIS patients with hyperglycemia. Evaluating serum ferritin level may be conducive to assess the risk of short-term poor outcome in AIS patients with hyperglycemia. Further studies will be required to confirm our findings.Cerebrovasc Dis
Source: Cerebrovascular Diseases - December 14, 2022 Category: Neurology Source Type: research

Translational Molecular Imaging Tool of Vulnerable Carotid Plaque: Evaluate Effects of Statin Therapy on Plaque Inflammation and American Heart Association –Defined Risk Levels in Cuff-Implanted Apolipoprotein E–Deficient Mice
AbstractIdentification of high-risk carotid plaques in asymptomatic patients remains a challenging but crucial step in stroke prevention. The challenge is to accurately monitor the development of high-risk carotid plaques and promptly identify patients, who are unresponsive to best medical therapy, and hence targeted for carotid surgical interventions to prevent stroke. Inflammation is a key operator in destabilisation of plaques prior to clinical sequelae. Currently, there is a lack of imaging tool in routine clinical practice, which allows assessment of inflammatory activity within the atherosclerotic plaque. Herein, we ...
Source: Translational Stroke Research - December 9, 2022 Category: Neurology Source Type: research