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Failure of Therapeutic Anticoagulation in COVID-19 Patients With Acute Ischemic Stroke. A Retrospective Multicenter Study
ConclusionsThe occurrence of an anticoagulation failure seems to be increased in the setting of COVID-19 infection, with worse clinical outcomes if compared to non-COVID-19 related ischemic strokes. We discuss the diagnostic and therapeutic implications of such evidence, suggesting that some arterial thrombotic complications might be either resistant to or independent of the anticoagulation effect.
Source: Frontiers in Neurology - March 4, 2022 Category: Neurology Source Type: research

Neurological emergency at the COVID-19 pandemic: report from a referral hospital in Eastern Piedmont, Italy
We described how the flow of neurological emergencies was affected by the pandemic impact.MethodsWe analyzed accesses to the Emergency Department (ED) of the “Maggiore della Carità” Hospital, Piedmont, Italy, during a period of 8 months (COVID time; March to May 2020 and October 2020 to February 2021) and analyzed the admissions to the Neurology Unit and the underlying diagnosis. We also evaluated potential changes in the treatment of acute ischemi c stroke in the same period. These variables were compared with two equivalent periods of time (2019–2020; 2018–2019).ResultsDuring the COVID time, there was a clear-c...
Source: Neurological Sciences - January 18, 2022 Category: Neurology Source Type: research

Risk of ischemic stroke in patients with COVID-19 infection: A systematic review and meta-analysis
This study systematically reviewed published studies and conducted meta-analysis to evaluate the association between the risk of ischemic stroke and COVID-19. This study was conducted according to guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The protocol used in this study had been registered in the International Prospective Register of Systematic Reviews. EMBASE, PubMed, Cochrane Library and Web of Science were searched from 1st December 2019-19th February 2021. This systematic review and meta-analysis analysed the combined effect estimations based on odds ratios (OR) with the ra...
Source: Brain Research Bulletin - January 3, 2022 Category: Neurology Authors: Yanhua Cui Bing Zhao Tianbai Li Zhaofei Yang Song Li Weidong Le Source Type: research

Patent Foramen Ovale related cryptogenic stroke during COVID-19 disease in three patients: a case series
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), termed COVID-19, first detected in Whuan, was officially declared a pandemic by the World Health Organization on March 11, 2020. The epidemic of COVID-19 has rapidly spread worldwide. Italy was the first European country to be affected and, currently, Italy has reported 4,343,397 COVID-19-positive cases (1).
Source: Journal of Stroke and Cerebrovascular Diseases - September 13, 2021 Category: Neurology Authors: Daniela Palleri, Marta Guidarini, Elisabetta Mariucci, Anna Balducci, Gabriele Egidy Assenza, Susanna Esposito, Andrea Donti Source Type: research

Stroke care in Italy at the time of the COVID-19 pandemic: a lesson to learn
AbstractFrom March to May 2020, the Italian health care system, as many others, was almost entirely devoted to the fight against the COVID-19 pandemic. In this context, a number of questions arose, from the increased stroke risk due to COVID-19 infection to the quality of stroke patient care. The overwhelming need of COVID-19 patient management made mandatory a complete re-organization of the stroke pathways: many health professionals were reallocated and a number of stroke units was turned into COVID-19 wards. As a result, acute stroke care suffered from a shortage of services and delays in time-dependent treatments and d...
Source: Journal of Neurology - June 21, 2021 Category: Neurology Source Type: research

SARS-CoV-2 infection and acute ischemic stroke in Lombardy, Italy
ConclusionsIschemic strokes in COVID-19 patients have distinctive risk factor profile and etiology, increased clinical severity and higher in-hospital mortality rate compared to non-COVID-19 patients. A simple model based on clinical and routine laboratory parameters may be useful in identifying ischemic stroke patients with SARS-CoV-2 infection who are unlikely to survive the acute phase.
Source: Journal of Neurology - May 24, 2021 Category: Neurology Source Type: research

Response to Letter to the Editor
We would like to thank Dr Nzwalo and Dr Logallo for their interest in our paper about the impact of the lockdown measures, enforced in March 2020 to control the spread of Covid-19 outbreak, on stroke admissions and treatments in Campania, the third most-populous and the most-densely populated region in Italy.
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2021 Category: Neurology Authors: Paolo Candelaresi Tags: Letter to the Editor Source Type: research

Response to letter to the editor,
We would like to thank Dr Nzwalo and Dr Logallo for their interest in our paper about the impact of the lockdown measures, enforced in March 2020 to control the spread of Covid-19 outbreak, on stroke admissions and treatments in Campania, the third most-populous and the most-densely populated region in Italy.
Source: Journal of Stroke and Cerebrovascular Diseases - March 10, 2021 Category: Neurology Authors: Paolo Candelaresi Tags: Letter to the Editor Source Type: research

Impact of SARS-CoV-2 on reperfusion therapies for acute ischemic stroke in Lombardy, Italy: the STROKOVID network
AbstractWhether and how SARS-CoV-2 outbreak affected in-hospital acute stroke care system is still matter of debate. In the setting of the STROKOVID network, a collaborative project between the ten centers designed as hubs for the treatment of acute stroke during SARS-CoV-2 outbreak in Lombardy, Italy, we retrospectively compared clinical features and process measures of patients with confirmed infection (COVID-19) and non-infected patients (non-COVID-19) who underwent reperfusion therapies for acute ischemic stroke. Between March 8 and April 30, 2020, 296 consecutive patients [median age, 74 years (interquartile range (IQ...
Source: Journal of Neurology - March 8, 2021 Category: Neurology Source Type: research

Stroke management during the coronavirus disease 2019 (COVID-19) pandemic: experience from three regions of the north east of Italy (Veneto, Friuli-Venezia-Giulia, Trentino-Alto-Adige)
ConclusionsOur study confirmed a decrease in admission rate of stroke patients in a large area of northern Italy during the lockdown period, especially during the first dramatic phase. Overall, there was no decrease in thrombolysis rate, confirming an effect of emergency care system for stroke patients. Instead, the significant decrease in thrombectomy rate during lockdown addresses some considerations of local and regional stroke networks during COVID-19 pandemic evolution.
Source: Neurological Sciences - March 4, 2021 Category: Neurology Source Type: research

Stroke and digital technology: a wake-up call from COVID-19 pandemic
ConclusionThe global emergency represented by the COVID-19 pandemic can be the stimulus to accelerate the digitalization process in the field of stroke for the use of new methods on a large scale.
Source: Neurological Sciences - January 12, 2021 Category: Neurology Source Type: research

Who is really blind in the time of coronavirus: the patient or the doctor? A rare case of Balint ’s syndrome
ConclusionDuring SARS-CoV2 pandemic, Italian physicians were forced to work with less instrumental diagnostic resources, relying on their clinical knowledge mostly. The aim of this case report is to highlight the importance of performing a precise neurological evaluation, particularly during these challenging times: it might avoid incorrect diagnosis and favour the discovery of rare clinical diseases.
Source: Neurological Sciences - January 5, 2021 Category: Neurology Source Type: research

The impact of Covid-19 lockdown on stroke admissions and treatments in Campania
This study analyses the impact of Covid-19 pandemic and lockdown measures on the incidence of stroke, in Campania, the most densely-populated region in Italy.Methods: we retrospectively analysed data regarding acute stroke patients presenting at 5 Campania stroke hubs, before and after the issue of lockdown in Italy on March 9th, 2020.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2020 Category: Neurology Authors: Candelaresi Paolo, Manzo Valentino, Giovanna Servillo, Muto Mario, Barone Paolo, Napoletano Rosa, Saponiero Renato, Andreone Vincenzo, Palma Vincenzo, Spitaleri Daniele, D'Onofrio Florindo, Maniscalco Giorgia, Salvatore Simona, Leone Giuseppe, Capone Elis Source Type: research

The stroke mothership model survived during COVID-19 era: an observational single-center study in Emilia-Romagna, Italy
ConclusionDuring COVID-19 pandemic, TIA and minor stroke consistently reduced compared to the same timeframe in 2019. Longer stroke-to-call and door-to-scan times, attributable to change in citizen behavior and screening at hospital arrival, did not impact on stroke-to-treatment time. Mothership model might have minimized the effects of the pandemic on the stroke care organization.
Source: Neurological Sciences - October 8, 2020 Category: Neurology Source Type: research

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