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Specialty: Neurology
Infectious Disease: SARS
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Total 341 results found since Jan 2013.
Acute Cerebrovascular Disorders and Vasculopathies associated with Significant Mortality in SARS-CoV-2 patients admitted to the Intensive Care Unit in The New York Epicenter
We present a case series of consecutive COVID-19 patients with cerebrovascular disease treated at our institution including 3 cases of cerebral artery dissection including subarachnoid hemorrhage. Knowledge of the varied presentations including dissections will help treating clinicians at the bedside monitor and manage these complications preemptively.
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Fawaz Al-Mufti, Christian Becker, Haris Kamal, Hussein Alshammari, Vincent Dodson, Rolla Nuoman, Katarina Dakay, Jared Coper, Edwin Gulko, Gurmeen Kaur, Ramandeep Sahni, Corey Scurlock, Stephan A. Mayer, Chirag D. Gandhi Source Type: research
Intracranial hemorrhage in hospitalized SARS-CoV-2 Patients: A Case Series
The SARS-CoV-2 virus causing Coronavirus Disease 2019 (COVID-19) is a global pandemic with almost 30 million confirmed worldwide cases. Prothrombotic complications arising from those affected with severe symptoms have been reported in various medical journals. Currently, clinical trials are underway to address the questions regarding anticoagulation dosing strategies to prevent thrombosis for these critically ill patients. However, given the increasing use of therapeutic anticoagulation in patients admitted with COVID-19 to curtail this prothrombotic state, our institution has witnessed six cases of devastating intracrania...
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Fady Mousa-Ibrahim, Stephanie Berg, Oluwatobi Odetola, Michael Teitcher, Sean Ruland Source Type: research
COVID-19 Associated Ischemic Stroke and Hemorrhagic Stroke: Incidence, Potential Pathological Mechanism, and Management
The outbreak of the novel coronavirus infectious disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has rapidly spread around the world. Increasing evidence has suggested that patients with COVID-19 may present neurological symptoms, and cerebrovascular diseases are one of the most frequent comorbidities. The markedly elevated D-dimer levels in patients with acute ischemic stroke suggests that SARS-CoV-2 infection may induce an inflammatory response and trigger a hypercoagulation state, thus leading to acute ischemic stroke. Cardioembolism and atherosclerosis in patients with COVID-19 infection may also increase the ri...
Source: Frontiers in Neurology - October 27, 2020 Category: Neurology Source Type: research
Editorial
The cover of this issue ofBrain relates to the article by Ross Paterson, Rachel Brown and co-workers that describes the range of neurological presentations in patients with definite, probable or possible COVID-19 encountered in a series of multidisciplinary team meetings organized at a single neurological centre. The commonest CNS disorders encountered were encephalopathy without obvious structural lesion or CSF abnormality, encephalitis or encephalomyelitis, and ischaemic stroke, often in the context of a hypercoagulable state. The accepted manuscript has already been downloaded almost 30 000 times even before formal p...
Source: Brain - October 25, 2020 Category: Neurology Source Type: research
Covid-19 and major organ thromboembolism: manifestations in neurovascular and cardiovascular systems.
COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been shown to cause multisystemic damage. We undertook a systematic literature review and comprehensive analysis of a total of 55 articles on arterial and venous thromboembolism in COVID-19 and articles on previous pandemics with respect to thromboembolism and compared the similarities and differences between them. The presence of thrombosis in multiple organ systems points to thromboembolism being an integral component in the pathogenesis of this disease.
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2020 Category: Neurology Authors: Presaad Pillai, Joyce Pauline Joseph, Nurul Huda Mohamad Fadzillah, Masliza Mahmod Tags: Review Article Source Type: research
Challenges in Brain Death Determination and Apnea Testing for Patients with COVID-19
Apnea testing remains essential for the clinical evaluation of brain death determination. In patients who test positive for SARS-CoV-2, disconnecting the patient from the ventilator and introducing high flow oxygen into the endotracheal tube increases the risk for aerosolization of airway secretions and exposure of the examiner.
Source: Journal of Stroke and Cerebrovascular Diseases - October 21, 2020 Category: Neurology Authors: Yazan Radaideh, Rajeev Garg, Amina A. Abdalla, Ankeet D Patel, Sayona John, Ivan Da Silva Source Type: research
Encephalopathy in COVID-19 Presenting With Acute Aphasia Mimicking Stroke
Conclusions: We report a patient with reversible COVID-19-related encephalopathy presenting as acute aphasia, mimicking stroke or status epilepticus, eventually evolving into delirium. Although large-vessel stroke is frequently encountered in COVID-19, our case suggests that focal neurological deficits may occur as the earliest feature of encephalopathy. Neurological status reversibility and the absence of abnormalities on brain MRI are consistent with a functional rather than a structural neuronal network impairment.
Source: Frontiers in Neurology - October 19, 2020 Category: Neurology Source Type: research
Cerebral Venous Sinus Thromboses in Patients with SARS-CoV-2 Infection: Three Cases and a Review of the Literature
: Early studies suggest that acute cerebrovascular events may be common in patients with coronavirus disease 2019 (COVID-19) and may be associated with a high mortality rate. Most cerebrovascular events described have been ischemic strokes, but both intracerebral hemorrhage and rarely cerebral venous sinus thrombosis (CVST) have also been reported. The diagnosis of CVST can be elusive, with wide-ranging and nonspecific presenting symptoms that can include headache or altered sensorium alone.
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2020 Category: Neurology Authors: Felix Nwajei, Pria Anand, Mohamad Abdalkader, Vanesa C. Andreu Arasa, Hugo J. Aparicio, Siavash Behbahani, Gioacchino Curiale, Ali Daneshmand, Hormuzdiyar Dasenbrock, Thomas Mayo, Asim Mian, Thanh Nguyen, Charlene Ong, J. Rafael Romero, Osamu Sakai, Court Source Type: research
Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
ConclusionNeurological disturbances represent a significant and severe burden in COVID-19 patients, and they can be the presenting condition that leads to the diagnosis of the viral infection in a high percentage of patients. Evidence of direct viral mechanisms was scarce, but the pathogenesis of the diverse manifestations remains enigmatic.
Source: Neurological Sciences - October 16, 2020 Category: Neurology Source Type: research
An Example of a Stroke Unit Reshaping in the Context of a Regional Hub and Spoke System in the COVID-19 Era
In conclusion, we were able to manage the new hub-and-spoke system safely and without significant delays. The reshaping of the SU was made possible by the significant reduction of out-patient activity. The consequences of this reduction are still unknown but eventually, this emergency will suggest ways to reconsider the management and the allocation of health system resources.
Source: Frontiers in Neurology - October 15, 2020 Category: Neurology Source Type: research
Cerebral venous sinus thrombosis associated with SARS-CoV-2; a multinational case series
We present a series of CVST cases with SARS-CoV-2 infection.Methods In a multinational retrospective study, we collected all cases of CVST in SARS-CoV-2 infected patients admitted to nine tertiary stroke centers from the beginning of the pandemic to June 30th, 2020. We compared the demographics, clinical and radiological characteristics, risk factors, and outcome of these patients with a control group of non-SARS-CoV-2 infected CVST patients in the same seasonal period of the years 2012 –2016 from the country where the majority of cases were recruited.
Source: Journal of the Neurological Sciences - October 14, 2020 Category: Neurology Authors: Ashkan Mowla, Banafsheh Shakibajahromi, Shima Shahjouei, Afshin Borhani-Haghighi, Nasrin Rahimian, Humain Baharvahdat, Soheil Naderi, Fariborz Khorvash, Davar Altafi, Seyed Amir Ebrahimzadeh, Ghasem Farahmand, Alaleh Vaghefi Far, Vijay K. Sharma, Saeideh Source Type: research
Cerebral Herniation Secondary to Stroke-associated Hemorrhagic Transformation, Fulminant Cerebral Edema in Setting of COVID-19 Associated ARDS and Active Malignancy
We present the case of a very rapid neurologic and radiographic decline of a patient with an acute ischemic stroke who developed rapid fulminant cerebral edema leading to herniation in the setting of hypercarbic respiratory failure attributed to SARS-CoV-2 infection.
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2020 Category: Neurology Authors: Katarina Dakay, Gurmeen Kaur, Stephan A. Mayer, Justin Santarelli, Chirag Gandhi, Fawaz Al-Mufti Tags: Case Report Source Type: research
Stroke and Thromboprophylaxis in the era of COVID-19
In the rapidly evolving COVID-19 pandemic, many patients presenting with acute ischemic stroke may be potentially infected with the Severe Acute Respiratory Syndrome Coronavirus (SARS CoV-2) agent. As stroke patients are often unable to give an adequate history of preceding COVID-19 symptoms, all stroke patients in areas with high prevalence of community transmission should be considered potential cases. Observational studies have suggested an increased tendency for thrombotic events in patients infected with SARS CoV-2.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2020 Category: Neurology Authors: Alice Ma, Carlos S. Kase, Ashkan Shoamanesh, Mohamad Abdalkader, Aleksandra Pikula, Anvitha Sathya, Luciana Catanese, Alun T. Ellis, Thanh N. Nguyen Source Type: research
Cross-Talk Between Key Players in Patients with COVID-19 and Ischemic Stroke: A Review on Neurobiological Insight of the Pandemic
AbstractThe global pandemic of novel coronavirus disease 2019 (COVID-19) has taken the entire human race by surprise and led to an unprecedented number of mortalities worldwide so far. Current clinical studies have interpreted that angiotensin-converting enzyme 2 (ACE2) is the host receptor for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). In addition, ACE2 is the major component of the renin-angiotensin system. ACE2 deteriorates angiotensin II, a peptide that is responsible for the promotion of stroke. The downregulation of ACE2 further activates an immunological cascade. Thus, researchers need to explore ...
Source: Molecular Neurobiology - October 7, 2020 Category: Neurology Source Type: research
Acute Ischemic Stroke in COVID-19: A Case-Based Systematic Review
Corona virus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) is recognized as a global pandemic by WHO 2020 with 5,934 936 infections, 367,166 deaths and affecting over 200 countries as of 30th May 2020. Acute Ischemic Stroke (AIS) in brain is also emerging as an important neurovascular/neurological complication of COVID-19, associated with extreme immune responses leading to dysregulated coagulation system and generalized thrombo-embolic status and increased risk of AIS especially among usually less vulnerable younger adults in this cohort. Thus, in early June 2020, we aimed t...
Source: Frontiers in Neurology - September 24, 2020 Category: Neurology Source Type: research
