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Specialty: Neurology
Source: Frontiers in Neurology
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Total 2557 results found since Jan 2013.
Recent progress in patent foramen ovale and related neurological diseases: A narrative review
Patent foramen ovale (PFO) is a common congenital cardiac abnormality when the opening of the interatrial septum is not closed in adulthood. This abnormality affects 25% of the general population. With the development of precision medicine, an increasing number of clinical studies have reported that PFO is closely related to various neurological diseases such as stroke, migraine, obstructive sleep apnea, and decompression syndrome. It has also been suggested that PFO closure could be effective for preventing and treating these neurological diseases. Therefore, increasing attention has been given to the prevention, diagnosi...
Source: Frontiers in Neurology - March 27, 2023 Category: Neurology Source Type: research
Rescue thrombolysis for medium vessel occlusion (RESCUE-TNK): Rationale and design of a phase 2 randomized trial
ConclusionThe results of RESCUE-TNK will provide evidence for the efficacy and safety of intra-arterial TNK in the recanalization of patients with MeVO.
Source: Frontiers in Neurology - March 27, 2023 Category: Neurology Source Type: research
Adherens, tight, and gap junctions in ependymal cells: A systematic review of their contribution to CSF-brain barrier
ConclusionsThese findings may provide an opportunity for medical management of CSF disorders, potentially allowing for tuning of CSF secretion and absorption. Beyond hydrocephalus, stroke, trauma, this information has relevance for metabolite clearance and drug delivery, with potential to affect many patients with a variety of neurological disorders. This critical look at intercellular junctions in ependyma and the surrounding interstitial spaces is meant to inspire future research on a central and rather unknown component of the CSF-brain interface.
Source: Frontiers in Neurology - March 24, 2023 Category: Neurology Source Type: research
Clinical factors associated with functional outcomes in patients with single subcortical infarction with neurological deterioration
ConclusionsND is an independent predictor of poor outcomes in patients with SSI, and poor outcome determinants in the SSI-ND subgroup and in all patients with SSI are not identical. For patients with SSI-ND, PAD could aggravate ND and was therefore an essential predictor of poor outcomes.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
Clinical factors associated with functional outcome in patients with single subcortical infarction with neurological deterioration
Conclusions: ND is an independent predictor of poor outcome in patients with SSI, and poor outcome determiners are not identical in the SSI-ND subgroup and all SSI patients. For patients with SSI-ND, PAD could aggravate ND and hence is an essential predictor of poor outcome.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
Echocardiographic correlates of MRI imaging markers of cerebral small-vessel disease in patients with atrial-fibrillation-related ischemic stroke
ConclusionIn patients with AF-related ischemic stroke, LVPW is associated with a higher risk of lacunes and CSVD burden, while RAD was associated with greater CSO-EPVS. Larger studies are required to determine these associations and to elucidate if these associations can help facilitate cognitive evaluation and brain MRI screening.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
Segmentation of incident lacunes during the course of ischemic cerebral small vessel diseases
ConclusionThe automatic segmentation of incident lacunes followed by quick corrections of false positives appears promising for properly and rapidly quantifying incident lacunes in large cohorts of cSVDs.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
An optimal model of long-term post-stroke care
This article synthesized information from systematic reviews, guidelines, and primary literature on stroke care and post-stroke rehabilitation and proposes an optimal strategy for long-term post-stroke care. It also highlights the unmet needs of patients who experienced a stroke in terms of early diagnosis of complications and adequate, comprehensive therapy.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
Effect of acupuncture combined with antidepressants on post-stroke depression: A network meta-analysis of nine acupuncture therapy
ConclusionA comparison of the efficacy indicators of the nine different acupuncture therapies combined showed that moxibustion plus antidepressants, conventional acupuncture plus antidepressants and acupressure plus antidepressants were superior in the treatment of PSD. Based on the shortcomings of the existing studies, this conclusion needs to be validated by additional high-quality randomized controlled trials.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
Current status and future aspects in the Japan Stroke Data Bank
The Japanese National Plan for the Promotion of Measures Against Cerebrovascular and Cardiovascular Diseases was formulated on October 27, 2020. One purpose of this plan was to promote research on cerebrovascular and cardiovascular diseases. Therefore, it is necessary to clarify the actual status of stroke treatment in Japan and operate a national stroke database with high public interest completely and accurately. The Japan Stroke Data Bank (JSDB; https://strokedatabank.ncvc.go.jp/en/) was established by the Ministry of Health, Labor and Welfare Scientific Research in Shimane University (Shimane, Japan) in 1999 and was tr...
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research
Risk factors for intracerebral hemorrhage in patients undergoing maintenance hemodialysis
ConclusionHigher systolic BP and abnormal iPTH metabolism might be associated with ICH in patients undergoing hemodialysis. Comprehensive control of hypertension and iPTH may be a fundamental preventive strategy for ICH in these patients.
Source: Frontiers in Neurology - March 22, 2023 Category: Neurology Source Type: research
MCP extensors respond faster than flexors in individuals with severe-to-moderate stroke-caused impairment: Evidence of uncoupled neural pathways
In this study, a total of seven male participants with severe-to-moderate impairment by a hemiplegic stroke conducted flexion and extension at the metacarpophalangeal (MCP) joints in response to auditory tones. We measured activation and de-activation delays of the flexor and extensor of the MCP joints on the paretic side, and force generation. All participants generated greater torque in the direction of flexion (p = 0.017). Regarding co-contraction, coupled activation of the extensor is also made during flexion in the similar way to coupled activation of the flexor made during extension. As opposite to our expectation, w...
Source: Frontiers in Neurology - March 22, 2023 Category: Neurology Source Type: research
Angiotensin-converting enzyme gene insertion/deletion polymorphism and risk of ischemic stroke complication among patients with hypertension in the Ethiopian population
ConclusionThere is a significant correlation between the ACE gene I/D polymorphism and the development of ischemic stroke in patients with a history of hypertension in the Ethiopian population.
Source: Frontiers in Neurology - March 22, 2023 Category: Neurology Source Type: research
Characteristics of stroke after liver and kidney transplantation
ConclusionsIn-hospital, perioperative, and hemorrhagic strokes were more common in the LT group than in the KT group. Ischemic stroke subtypes did not differ significantly between the two groups and undetermined etiology was the most common cause of ischemic stroke in both groups. High mortality after stroke was noted in transplantation patients and was associated with in-hospital stroke.
Source: Frontiers in Neurology - March 22, 2023 Category: Neurology Source Type: research
A review of stress-induced hyperglycaemia in the context of acute ischaemic stroke: Definition, underlying mechanisms, and the status of insulin therapy
The transient elevation of blood glucose produced following acute ischaemic stroke (AIS) has been described as stress-induced hyperglycaemia (SIH). SIH is common even in patients with AIS who have no previous diagnosis of diabetes mellitus. Elevated blood glucose levels during admission and hospitalization are strongly associated with enlarged infarct size and adverse prognosis in AIS patients. However, insulin-intensive glucose control therapy defined by admission blood glucose for SIH has not achieved the desired results, and new treatment ideas are urgently required. First, we explore the various definitions of SIH in t...
Source: Frontiers in Neurology - March 21, 2023 Category: Neurology Source Type: research
