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Specialty: Neurology
Source: Frontiers in Neurology

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Total 2557 results found since Jan 2013.

Microsurgical revascularization of a symptomatic proximal vertebral artery: pilot experiences from a single center
ConclusionMicrosurgical reconstruction is an alternative option that can effectively treat refractory proximal VASO disease and in-stent stenosis, with a high rate of postoperative vascular recirculation. Prospective cohort studies with larger sample sizes must be conducted to validate the above conclusions.
Source: Frontiers in Neurology - July 7, 2023 Category: Neurology Source Type: research

The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
Glutamate is the brain’s main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptors, AMPA receptors are the predominant mediator of glutamate-induced excitatory neurotransmission and dictate synaptic efficiency and plasticity by their numbers and/or properties. Therefore, they appear to be a major drug target for modulating several brain functions. Perampanel (PER) is a highly selective, noncompetitive AMPA...
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research

Prospective collection of blood plasma samples to identify potential biomarkers for the prehospital stroke diagnosis (ProGrEss-Bio): study protocol for a multicenter prospective observational study
This study will evaluate whether a single blood biomarker or a combination of biomarkers can distinguish patients with AIS and ICH from patients with stroke and SM in the early phase after symptom onset in the prehospital setting. In addition, the kinetics of blood biomarkers in AIS and ICH patients will be investigated. Our goal is to evaluate new ways to reliably diagnose stroke in the prehospital setting and thus accelerate the application of evidence-based therapies to stroke patients.
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research

Connectomic insight into unique stroke patient recovery after rTMS treatment
This study demonstrates for the first time the feasibility of using individualized connectivity analyses in differentiating unique phenotypes in rTMS treatment responses and recovery. This personalized connectomic approach may be utilized in the future to better understand patient recovery trajectories with neuromodulatory treatment.
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research

Serum amyloid A is a potential predictor of prognosis in acute ischemic stroke patients after intravenous thrombolysis
ConclusionSAA level that is up-regulated during hospitalization is capable of serving as an effective marker in terms of the prediction of unfavorable three-month results in AIS patients after IVT.
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research

A potential relationship between MMP-9 rs2250889 and ischemic stroke susceptibility
ConclusionOur study preliminarily confirmed that SNP rs2250889 was significantly associated with susceptibility to IS.
Source: Frontiers in Neurology - July 5, 2023 Category: Neurology Source Type: research

The association between serum phosphorus and common carotid artery intima –media thickness in ischemic stroke patients
ConclusionIn acute ischemic stroke patients, baseline elevated serum phosphorus level was found to be independently associated with carotid atherosclerosis, as measured by cIMT.
Source: Frontiers in Neurology - July 5, 2023 Category: Neurology Source Type: research

Evaluating cardiac function with chest computed tomography in acute ischemic stroke: feasibility and correlation with short-term outcome
ConclusionHydrostatic lung changes on chest CT can be used as an indicator of cardiac function and as a preliminary reference for short-term outcome in AIS patients.
Source: Frontiers in Neurology - July 5, 2023 Category: Neurology Source Type: research

Functional outcome in low-ASPECTS (0 –5) acute ischemic stroke treated with mechanical thrombectomy: impact of laterality explored in a single-center study
ConclusionThe clinical outcome was not significantly influenced by stroke laterality. The results of this single-center retrospective study indicate either a lack of strength or equal value in performing mechanical thrombectomy regardless of stroke laterality.
Source: Frontiers in Neurology - July 4, 2023 Category: Neurology Source Type: research

Cardiocerebrovascular risk in sensorineural hearing loss: results from the National Health and Nutrition Examination Survey 2015 to 2018
ConclusionOur findings suggested that a higher cardiocerebrovascular risk burden was associated with an increased risk of SNHL, and the relationship may be influenced by age and sex. Future longitudinal studies are needed to investigate the mechanistic and pathologic vascular hypothesis of SNHL.
Source: Frontiers in Neurology - July 4, 2023 Category: Neurology Source Type: research

Trends in deaths and disability-adjusted life-years of stroke attributable to high body-mass index worldwide, 1990 –2019
ConclusionA range of indicators for the global burden of stroke attributable to HBMI have been on the rise for the past three decades. Tremendous efforts worldwide should be in place to control and treat stroke attributable to HBMI, especially in regions with high-middle and middle SDIs and among middle-aged and aged populations.
Source: Frontiers in Neurology - June 30, 2023 Category: Neurology Source Type: research

Seasonal variation in the incidence of primary intracerebral hemorrhage: a 16-year nationwide analysis
ConclusionUnlike AIS, ICH incidence is consistently higher in colder quarters, underscoring the need for evaluation and prevention of factors driving seasonal variations in ICH incidence.
Source: Frontiers in Neurology - June 29, 2023 Category: Neurology Source Type: research

Associations between homocysteine and B vitamins and stroke: a cross-sectional study
ConclusionNon-linear associations of plasma Hcy and B vitamins levels with stroke prevalence were found in American adults. These associations may have an implication that higher plasma Hcy levels should be reduced, and plasma vitamin B6, vitamin B12 and folate levels should be moderately improved in stroke prevention. Future studies are needed to verify the causality of these associations and elucidate the underlying mechanisms.
Source: Frontiers in Neurology - June 29, 2023 Category: Neurology Source Type: research

Placebo effect after visual restitution training: no eye-tracking controlled perimetric improvement after visual border stimulation in late subacute and chronic visual field defects after stroke
DiscussionBright-light detection RT at the blind-field border solely induced a placebo effect and did not lead to training-induced neuroplasticity in the visual cortex of the type needed to ameliorate the visual field size of stroke patients.
Source: Frontiers in Neurology - June 29, 2023 Category: Neurology Source Type: research

The efficacy of community-based exercise programs on circulating irisin level, muscle strength, cardiorespiratory endurance, and body composition for ischemic stroke: a randomized controlled trial
ConclusionCEP might be an effective intervention to increase irisin levels and prevent a stroke-related decline in muscle function.
Source: Frontiers in Neurology - June 29, 2023 Category: Neurology Source Type: research