Adherens, tight, and gap junctions in ependymal cells: A systematic review of their contribution to CSF-brain barrier

ConclusionsThese findings may provide an opportunity for medical management of CSF disorders, potentially allowing for tuning of CSF secretion and absorption. Beyond hydrocephalus, stroke, trauma, this information has relevance for metabolite clearance and drug delivery, with potential to affect many patients with a variety of neurological disorders. This critical look at intercellular junctions in ependyma and the surrounding interstitial spaces is meant to inspire future research on a central and rather unknown component of the CSF-brain interface.
Source: Frontiers in Neurology - Category: Neurology Source Type: research