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Serum retinol-binding protein 4 in stroke patients: correlation with T helper 17/regulatory T cell imbalance and 3-year cognitive function decline
ConclusionSerum RBP4 is positively associated with a Th17/Treg cell imbalance and, more importantly, it is indicative of cognitive function decline within 3 years in stroke patients. Thus, early and timely interventions and physical rehabilitation are more necessary in stroke patients with high serum RBP4.
Source: Frontiers in Neurology - September 21, 2023 Category: Neurology Source Type: research

Age-related macular degeneration is associated with probable cerebral amyloid angiopathy: A case-control study
Age-related macular degeneration (AMD) is a common retinal degenerative disorder among older individuals. Amyloid deposits, a hallmark of cerebral amyloid angiopathy (CAA), may be involved in the pathogenesis of AMD. Since amyloid deposits may contribute to the development of both AMD and CAA, we hypothesized that patients with AMD have a higher prevalence of CAA.
Source: Journal of Stroke and Cerebrovascular Diseases - July 7, 2023 Category: Neurology Authors: Bhrugun Anisetti, Michael W. Stewart, Eric R. Eggenberger, Md Manjurul I. Shourav, Hossam Youssef, Ahamed Elkhair, Nilufer Ertekin-Taner, James F. Meschia, Michelle P. Lin Source Type: research

Adult-onset leukodystrophy with vanishing white matter: a case series of 19 patients
ConclusionsAO-LVWM presents varying clinical manifestations at onset, including stroke-like events. WM rarefaction is the most consistent diagnostic clue even in the latest onset cases. Spectroscopy and electrophysiological features are compatible with axon, rather than myelin, damage. Cerebral glucose metabolic abnormalities and retinal alterations can be present. LVWM might also be caused by a digenic inheritance affecting the eIF2B complex.
Source: Journal of Neurology - May 12, 2023 Category: Neurology Source Type: research

The impact of initial admission department on the management and prognosis of retinal artery occlusion
CONCLUSIONS: The study demonstrated that the visual prognosis of RAO was devastating regardless of the neurology and ophthalmology department. Given the admission delay, inadequate management, and high risk of cardiovascular risk factors and stroke, stroke centers should be recommended as initial admission departments for RAO patients.PMID:36305143 | DOI:10.2174/1567202620666221027091249
Source: Current Neurovascular Research - October 28, 2022 Category: Neurology Authors: Yanqin Liu Shuju Dong Yaxi Luo Yanbo Li Changling Li Dong Zhou Li He Source Type: research

Eye signs in stroke
Rajeshwar Sahonta, Ivy Sebastian, Sanjit Aaron, Appaswamy T Prabakhar, Anupriya Arthur, Jeyaraj D PandianAnnals of Indian Academy of Neurology 2022 25(8):94-100 A large part of the central nervous system is involved in the normal functioning of the vision, and hence vision can be affected in a stroke patient. Transient visual symptoms can likewise be a harbinger of stroke and prompt rapid evaluation for the prevention of recurrent stroke. A carotid artery disease can manifest as transient monocular visual loss (TMVL), central retinal artery occlusion (CRAO), anterior ischemic optic neuropathy or ocular ischemic syndrome (...
Source: Annals of Indian Academy of Neurology - October 19, 2022 Category: Neurology Authors: Rajeshwar Sahonta Ivy Sebastian Sanjit Aaron Appaswamy T Prabakhar Anupriya Arthur Jeyaraj D Pandian Source Type: research

Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
ConclusionA fast and fully automatic method can be used for stroke subtype risk assessment and classification based on fundus photographs alone.
Source: Frontiers in Neurology - August 22, 2022 Category: Neurology Source Type: research

Effects of remote ischemic conditioning on sleep complaints in Parkinson's disease –rationale, design, and protocol for a randomized controlled study
ConclusionThis study is a prospective randomized controlled trial to determine the safety, feasibility, and potential efficacy of RIC for patients with Parkinson's disease associated with EDS.
Source: Frontiers in Neurology - July 25, 2022 Category: Neurology Source Type: research

Similarities and Differences in Systemic Risk Factors for Retinal Artery Occlusion and Stroke: A Nationwide Case-Control Study
This study compares risk factor profiles for thromboembolism among patients with RAO and stroke, respectively.
Source: Journal of Stroke and Cerebrovascular Diseases - June 28, 2022 Category: Neurology Authors: Marie Ørskov, Henrik Vorum, Torben Bjerregaard Larsen, Gregory Y.H. Lip, Toke Bek, Flemming Skjøth Source Type: research

Central Retinal Artery Occlusion: Current Practice, Awareness and Prehospital Delays in Switzerland
ConclusionsCRAO awareness of the general population and physician awareness about the treatment options as well as the non-standardized prehospital organization, seems to be the main reason for the prehospital delays and impedes treating CRAO patients. Educational efforts should be undertaken to improve awareness about CRAO.
Source: Frontiers in Neurology - May 23, 2022 Category: Neurology Source Type: research

Vascular Reactivity to Hypercapnia Is Impaired in the Cerebral and Retinal Vasculature in the Acute Phase After Experimental Subarachnoid Hemorrhage
Conclusion: This study provides a detailed temporal analysis of impaired cerebral vascular CO2 reactivity starting immediately after SAH and lasting up to 6 h. Importantly, the retinal vessels participate in these acute changes underscoring the promising role of the retina as a potential non-invasive screening tool after SAH. Further studies will be required to determine the correlation with functional outcomes.
Source: Frontiers in Neurology - January 13, 2022 Category: Neurology Source Type: research

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