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Interpretable machine learning for predicting 28-day all-cause in-hospital mortality for hypertensive ischemic or hemorrhagic stroke patients in the ICU: a multi-center retrospective cohort study with internal and external cross-validation
ConclusionsThe XGBoost model accurately predicted 28-day all-cause in-hospital mortality among hypertensive ischemic or hemorrhagic stroke patients admitted to the ICU. The SHAP method can provide explicit explanations of personalized risk prediction, which can aid physicians in understanding the model.
Source: Frontiers in Neurology - August 8, 2023 Category: Neurology Source Type: research

Preventing development of post-stroke hyperexcitability by optogenetic or pharmacological stimulation of cortical excitatory activity
Neurobiol Dis. 2023 Jul 17;184:106233. doi: 10.1016/j.nbd.2023.106233. Online ahead of print.ABSTRACTStroke is the most common cause of acquired epilepsy, but treatment for preventing the development of post-stroke epilepsy is still unavailable. Since stroke results in neuronal damage and death as well as initial loss of activity in the affected brain region, homeostatic plasticity may be trigged and contribute to an increase in network hyperexcitability that underlies epileptogenesis. Correspondingly, enhancing brain activity may inhibit hyperexcitability from enhanced homeostatic plasticity and prevent post-stroke epilep...
Source: Neurobiology of Disease - July 19, 2023 Category: Neurology Authors: Yadav Adhikari Cun-Gen Ma Zhi Chai Xiaoming Jin Source Type: research

Association between intracranial vessel calcifications, structural brain damage, and cognitive impairment after minor strokes: a prospective study
ConclusionOur findings suggest that the ICCS, which is a simple and readily available imaging marker on NCCT, is associated with brain atrophy, microstructural damage, the extent of SVD, and may predict PSCI. This finding has implications for identifying individuals at risk for PSCI and implementing targeted interventions to mitigate this risk.
Source: Frontiers in Neurology - July 18, 2023 Category: Neurology Source Type: research

Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease
ConclusionThe frequency of coronary calcification was higher in subjects with stroke caused by large-artery atherosclerosis than in controls.
Source: Frontiers in Neurology - April 12, 2023 Category: Neurology Source Type: research

The Weakened Interaction Between HECTD4 and GluN2B in Ischemic Stroke Promotes Calcium Overload and Brain Injury Through a Mechanism Involving the Decrease of GluN2B and MALT1 Ubiquitination
This study explores the relationship between HECTD4, GluN2B, and MALT1, focusing on their role in brain injury in ischemic stroke. Rats were subjected to 2  h-ischemia followed by 24-h reperfusion to establish an ischemic stroke model. We observed the downregulation of HECTD4 and the upregulation of MALT1. Additionally, an increased GluN2B phosphorylation was concomitant with weakened interactions between HECTD4 and GluN2B, followed by decreased stria tal-enriched protein phosphatase (STEP61). Knockdown of HECTD4 exacerbated hypoxia- or NMDA-induced injury in nerve cells coincident with a decrease in GluN2B and MALT1 ubiq...
Source: Molecular Neurobiology - March 1, 2023 Category: Neurology Source Type: research

The effect of regulating MCU expression on experimental ischemic brain injury
Exp Neurol. 2023 Jan 23:114329. doi: 10.1016/j.expneurol.2023.114329. Online ahead of print.ABSTRACTMitochondrial calcium uniporter (MCU) is a critical channel for Ca2+ influx into mitochondria. The present study aimed to determine if MCU knockdown has beneficial effects on ischemic brain injury and to explore the underlying mechanisms. The present study demonstrated that MCU knockdown but not total knockout (KO) attenuated ischemia infarction volume and primary cortical neuronal cells' ischemic damage. MCU knockdown maintained mitochondrial ultrastructure, alleviated calcium overload, and reduced mitochondrial apoptosis. ...
Source: Experimental Neurology - January 26, 2023 Category: Neurology Authors: Jin Qin Lijuan Liu Lin Liu Zhou Zhou Yicong Zhou Kun Zhang Binbin Wang Honglin Lu Jina Ran Tianzhao Ma Yingzhen Zhang Zhongzhong Li Xiaoyun Liu Source Type: research

Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
CONCLUSION: From these results, it was observed that CD treatment could reduce neuronal necrosis and create anti-inflammatory, anti-edema, anti-oxidant, anti-apoptotic, and anti-autophagic effects in hypoxia/reperfusion injury in rats.PMID:36548871 | DOI:10.1080/01616412.2022.2159109
Source: Neurological Research - December 22, 2022 Category: Neurology Authors: Alemiddin Ozdemir Mustafa Ogden Bahar Kartal Asli Fahriye Ceylan Ulas Yuksel Bulent Bakar Source Type: research

Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats
In conclusion, MICU3 is expected to be a molecular marker and a potential therapeutic target for ICH.PMID:36549422 | DOI:10.1016/j.expneurol.2022.114302
Source: Experimental Neurology - December 22, 2022 Category: Neurology Authors: Jiahe Wang Siyuan Yang Haiying Li Haitao Shen Xiaocheng Lu Xiang Li Gang Chen Source Type: research

The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke
ConclusionThe current results found that ionized calcium might be associated with early neurological improvement, but had no association with 3 months' outcome in anterior circulation AIS patients after IVT.
Source: Brain and Behavior - December 7, 2022 Category: Neurology Authors: Yan ‐Li Qi, Qiong Wu, Xiao‐Qiu Li, Zhong‐He Zhou, Cheng Xia, Xin‐Hong Wang, Hui‐Sheng Chen Tags: ORIGINAL ARTICLE Source Type: research

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