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Role of tRNA-Derived Fragments in Neurological Disorders: a Review
AbstracttRFs are small tRNA derived fragments that are emerging as novel therapeutic targets and regulatory molecules in the pathophysiology of various neurological disorders. These are derived from precursor or mature tRNA, forming different subtypes that have been reported to be involved in neurological disorders like stroke, Alzheimer ’s, epilepsy, Parkinson’s, MELAS, autism, and Huntington’s disorder. tRFs were earlier believed to be random degradation debris of tRNAs. The significant variation in the expression level of tRFs in disease conditions indicates their salient role as key players in regulation of these...
Source: Molecular Neurobiology - January 19, 2023 Category: Neurology Source Type: research

An analysis of neurovascular disease markers in the hippocampus of Tupaia chinensis at different growth stages
DiscussionIt was suggested that when the hippocampus of T. chinensis developed from day 15 to 3 months, the expression of oxidatively phosphorylated proteins and RPs would vary over time. Meanwhile, the hippocamppal protein expression profile of T. chinensis after 3 months had become stable. Moreover, the study underlines that, during the early development of the hippocampus of T. chinensis, energy demand increases while protein synthesis decreases. The mitochondria of T. chinensis changes with age, and the oxidative phosphorylation metabolic pathway of mitochondria is closely related to neurovascular diseases, such as str...
Source: Frontiers in Neurology - January 17, 2023 Category: Neurology Source Type: research

Blood pressure and Alzheimer's disease: A review of meta-analysis
ConclusionSBP is associated with both cerebrovascular disease and AD. Therefore, future studies should use other uncontrolled factors, such as cardiovascular diseases, diabetes, and stroke, to explain the relationship between SBP and AD.
Source: Frontiers in Neurology - January 11, 2023 Category: Neurology Source Type: research

β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage
CONCLUSION: BHB can improve the cognitive impairment caused by CCH. The potential mechanisms of BHB may be through reducing neuroinflammation and protecting BBB.PMID:36577190 | DOI:10.1016/j.brainresbull.2022.12.011
Source: Brain Research Bulletin - December 28, 2022 Category: Neurology Authors: Zhitian Wang Tian Li Miaoyu Du Lei Zhang Linling Xu Hao Song Junjian Zhang Source Type: research

The importance of neuromuscular rate of force development for physical function in aging and common neurodegenerative disorders - a systematic review
J Musculoskelet Neuronal Interact. 2022 Dec 1;22(4):562-586.ABSTRACTWe systematically reviewed existing literature regarding lower extremity neuromuscular rate of force development (RFD), maximal muscle strength (Fmax), and physical function in neurodegenerative populations, and to what extent these outcomes are affected and/or associated. Following PRISMA guidelines, 4 databases (Pubmed, Embase, SPORTDiscus, Web of Science) were searched. Across aging, Parkinson Disease (PD), Alzheimer's Disease (AD), Multiple Sclerosis (MS), or Stroke, included studies should report (Part 1) deficits in lower extremity RFD, Fmax, and phy...
Source: Journal of Musculoskeletal Neuronal Interactions - December 2, 2022 Category: Neurology Authors: Sidsel D Lomborg Ulrik Dalgas Lars G Hvid Source Type: research

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