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The prognostic value of CZT SPECT myocardial blood flow (MBF) quantification in patients with ischemia and no obstructive coronary artery disease (INOCA): a pilot study
ConclusionThe preliminary results demonstrated that quantitative analysis on CZT SPECT provides prognostic value for INOCA patients, which may allow the stratification for early prevention and intervention.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 14, 2023 Category: Nuclear Medicine Source Type: research

Prognostic value of combined coronary angiography-derived IMR and myocardial perfusion imaging by CZT SPECT in INOCA
ConclusioncaIMR-derived CMD is associated with increased risk of MACE among INOCA patients. Patients with abnormalities on both caIMR and MPI had the worse outcomes.Graphical abstract
Source: Journal of Nuclear Cardiology - August 2, 2022 Category: Nuclear Medicine Source Type: research

Prognostic value of myocardial perfusion imaging with D-SPECT camera in patients with ischemia and no obstructive coronary artery disease (INOCA)
ConclusionsD-SPECT MPI provides excellent prognostic information, with a more severe prognosis in patients with abnormal D-SPECT MPI. INOCA patients with abnormal D-SPECT MPI experience a poor prognosis similar to that of patients with obstructive CAD.
Source: Journal of Nuclear Cardiology - September 29, 2020 Category: Nuclear Medicine Source Type: research

Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.
Authors: Heo GS, Sultan D, Liu Y Abstract Cardiovascular disease (CVD) remains the leading cause of death worldwide despite advances in diagnostic technologies and treatment strategies. The underlying cause of most CVD is atherosclerosis, a chronic disease driven by inflammatory reactions. Atherosclerotic plaque rupture could cause arterial occlusion leading to ischemic tissue injuries such as myocardial infarction (MI) and stroke. Clinically, most imaging modalities are based on anatomy and provide limited information about the on-going molecular activities affecting the vulnerability of atherosclerotic lesion for...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Clinical imaging of cardiovascular inflammation.
Authors: Calcagno C, Fayad ZA Abstract Cardiovascular disease due to atherosclerosis is the number one cause of morbidity and mortality worldwide. In the past twenty years, compelling preclinical and clinical data have indicated that a maladaptive inflammatory response plays a crucial role in the development of atherosclerosis initiation and progression in the vasculature, all the way to the onset of life-threatening cardiovascular events. Furthermore, inflammation is key to heart and brain damage and healing after myocardial infarction or stroke. Recent evidence indicates that this interplay between the vasculatur...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist
Conclusion: The tetraazamacrocyclic small molecule 64Cu-CuCB-bicyclam has been shown to be an imaging agent for the CXCR4 receptor that is likely to be applicable across a range of species. It has high affinity and stability and is suitable for preclinical research in immunocompetent murine models.
Source: Journal of Nuclear Medicine - January 1, 2020 Category: Nuclear Medicine Authors: Burke, B. P., Miranda, C. S., Lee, R. E., Renard, I., Nigam, S., Clemente, G. S., DHuys, T., Ruest, T., Domarkas, J., Thompson, J. A., Hubin, T. J., Schols, D., Cawthorne, C. J., Archibald, S. J. Tags: Basic Source Type: research

Regional, Artery-Specific Thresholds of Quantitative Myocardial Perfusion by PET Associated with Reduced Myocardial Infarction and Death After Revascularization in Stable Coronary Artery Disease
Conclusion: CFC by PET provides objective, regional, artery-specific, size–severity physiologic quantification of CAD severity associated with high risk of DMS that is significantly reduced after revascularization within 90 d after PET, an association not seen for moderate to mild perfusion abnormalities or medical treatment alone.
Source: Journal of Nuclear Medicine - February 28, 2019 Category: Nuclear Medicine Authors: Gould, K. L., Johnson, N. P., Roby, A. E., Nguyen, T., Kirkeeide, R., Haynie, M., Lai, D., Zhu, H., Patel, M. B., Smalling, R., Arain, S., Balan, P., Nguyen, T., Estrera, A., Sdringola, S., Madjid, M., Nascimbene, A., Loyalka, P., Kar, B., Gregoric, I., S Tags: Clinical Source Type: research

Nutrition, risk factors, prevention, and imaging: The 2018 Mario Verani Lecture
AbstractHeart disease has been the leading cause of death in the United States since 1918. Cardiac mortality rates have dramatically decreased in this era of advanced medical and interventional therapies. However, this has been aptly described as “mopping up the floor instead of turning off the faucet.” With this recognition, prevention in cardiology is poised to become a central focus. Within prevention, dietary intervention is recognized as the single largest opportunity for improved cardiovascular outcomes, including improvement or el imination of cardiac risk factors, prevention of myocardial infarction, stroke and...
Source: Journal of Nuclear Cardiology - November 5, 2018 Category: Nuclear Medicine Source Type: research

Rates of Referral to Coronary Angiography After Positron Emission Tomography (PET) Myocardial Perfusion Imaging (MPI)
Conclusions: About 1 in 5 patients undergoing PET MPI are referred for coronary angiography within 90 days of testing, a rate greater than that reported for SPECT MPI, likely due to higher baseline risk of patients undergoing PET MPI testing. While referral rates for coronary angiography varied based on the presence or absence of prior documented clinical CAD and presence of test abnormalities, nearly 36% of patients with moderate-severe ischemia were not referred. Further work is needed to characterize why such patients are not referred for invasive evaluation to optimize the use of PET MPI in this high-risk population.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Patel, K., Spertus, J., Kureshi, F., Al Badarin, F., McGhie, A., Kennedy, K., Courter, S., Case, J., Thompson, R., Chan, P., Bateman, T. Tags: Cardiovascular Clinical Science Poster Session Source Type: research

Imaging thrombosis with 99mTc-labeled RAM.1-antibody in vivo
Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.1).
Source: Nuclear Medicine and Biology - March 16, 2018 Category: Nuclear Medicine Authors: Ali Ouadi, Virgile Bekaert, Nicolas Receveur, Lionel Thomas, Fran çois Lanza, Patrice Marchand, Christian Gachet, Pierre H. Mangin, David Brasse, Patrice Laquerriere Source Type: research

Imaging Thrombosis with 99mTc-labeled RAM.1-Antibody in vivo
Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.1).
Source: Nuclear Medicine and Biology - March 16, 2018 Category: Nuclear Medicine Authors: Ali Ouadi, Virgile Bekaert, Nicolas Receveur, Lionel Thomas, Fran çois Lanza, Patrice Marchand, Christian Gachet, Pierre H. Mangin, David Brasse, Patrice Laquerriere Source Type: research

18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi
Conclusions: 18F-GP1 binds specifically with high affinity to the GPIIb/IIIa receptor involved in platelet aggregation. Because of its favorable preclinical characteristics, 18F-GP1 is currently being investigated in a human clinical study.
Source: Journal of Nuclear Medicine - July 3, 2017 Category: Nuclear Medicine Authors: Lohrke, J., Siebeneicher, H., Berger, M., Reinhardt, M., Berndt, M., Mueller, A., Zerna, M., Koglin, N., Oden, F., Bauser, M., Friebe, M., Dinkelborg, L. M., Huetter, J., Stephens, A. W. Tags: Basic Source Type: research

A bradykinin derivative differentiates vulnerable and stable plaques in rhesus monkeys with positron emission tomography
Conclusion: P05022 selectively binds to B1R in vivo and generates high contrast images of vulnerable atherosclerotic plaque in monkey model. Our results suggest that P05022 is a promising PET tracer that can differentiate vulnerable atherosclerotic plaques from stable ones with significant specificity.
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Xu, Y., Zhang, Z., Benard, F., Lin, K.-S., Liu, Z. Tags: Hermann Blumgart Lecture & amp; Award Session Source Type: research

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