• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

60 Years of Achievements by KSNM in Neuroimaging Research
AbstractNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60  years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfusion SPECT was conducted. With the spread of positron emission tomography (PET) scanners in...
Source: Nuclear Medicine and Molecular Imaging - January 15, 2022 Category: Nuclear Medicine Source Type: research

Automated radiosynthesis and in vivo PET evaluation of VEGFR2 ligand 11CBTFP
Conclusions: [11C]BTFP, a high affinity and selective VEGFR2 ligand amenable for radiolabeling with [11C]isotope, is synthesized and radiolabeled. microPET imaging studies exhibit BBB penetration and retention of [11C]BTFP in mice brain. The details of radiosynthesis and imaging experiments will be presented. References: (1) Shim, J.W.; Madsen, J.R. VEGF Signaling in Neurological Disorders. Int. J. Mol. Sci. 2018, 19(1): 275. (2) Apte RS, Chen DS, Ferrara N. VEGF in Signaling and Disease: Beyond Discovery and Development. Cell. 2019, 176(6):1248.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Neelamegam, R., Kumar, D. Tags: Automation & amp; Technology Development Source Type: research

Brain-related complications of COVID-19 and the role of FDG-PET in detecting vascular and non-vascular defects throughout the body
Conclusions FDG-PET can characterize the extent of systemic disease in COVID-19 patients and provide value in the early identification of complications that may make patients more susceptible to the harmful respiratory and systemic side effects of COVID-19. Severe neurological ramifications of COVID-19 have been noted such as the increased prevalence of acute cerebrovascular incidents. In these contexts, emerging literature has proven that the use of FDG-PET can be useful in monitoring the neurological manifestations the COVID-19 virus.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Rigney, G., Ayubcha, C., Werner, T., Revheim, M.-E., Alavi, A. Tags: Neurosciences Source Type: research

Multi-scale optoacoustic molecular imaging of brain diseases
We describe outstanding challenges in optoacoustic imaging methodologies and propose a future outlook.
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 16, 2021 Category: Nuclear Medicine Source Type: research

Demarcation of Sepsis-Induced Peripheral and Central Acidosis with pH (Low) Insertion Cycle Peptide
Conclusion: Here, we demonstrate that a pH-sensitive PET tracer specifically detects acidosis in regions associated with sepsis-driven proinflammatory responses. This study suggests that [64Cu]Cu-pHLIC is a valuable tool to noninvasively assess acidosis associated with both central and peripheral innate immune activation.
Source: Journal of Nuclear Medicine - August 31, 2020 Category: Nuclear Medicine Authors: Henry, K. E., Chaney, A. M., Nagle, V. L., Cropper, H. C., Mozaffari, S., Slaybaugh, G., Parang, K., Andreev, O. A., Reshetnyak, Y. K., James, M. L., Lewis, J. S. Tags: Basic Source Type: research

Polyoxometalate nanoclusters act as broad-spectrum antioxidants to alleviate ischemic stroke by intrathecal injection
Conclusion: Intrathecal injection significantly improved the delivery and efficacy of POM nanoclusters to the brain, resulting in the rapid accumulation of POM nanoclusters in the ischemic penumbra. Due to this, we confirmed that the POM nanoclusters could be used as nano-antioxidants to inhibit oxidative stress as well as inflammatory damage effectively.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rosenkrans, Z., Li, S., Jiang, D., NI, D., Engle, J., Cai, W. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research

Evaluation of 11CTMI as a COX-2 selective PET tracer in baboon
Conclusion: Our PET imaging studies in baboon show that [11C]TMI penetrates the BBB and distributes to COX-2 enriched brain regions. Details of the in vivo evaluation of [11C]TMI in baboon brain will be presented. References 1. Majo VJ et al., Bioorg Med Chem Let., 2005, 15, 4268. 2. Cunningham VJ et al., J Cereb Blood Flow Metab., 2010; 30(1): 46-50. Grant Support: Diane Goldberg Foundation (NYSPI/CUMC) and Pfizer Inc.
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Kumar, D., Zanderigo, F., Prabhakaran, J., Rubin-Falcone, H., Parsey, R., Mann, J. J. Tags: Neuroscience - Basic Science - Posters Source Type: research

All That Glitters Is not Gold: Peals and Pitfalls in I-131 Scans for Differentiated Thyroid Cancer
Conclusion: We review thyroid gland physiology and describe a systemic overview of potential false positive and false negative lack of uptake of radioiodine in the whole body along with illustrations and cases. By understanding the physiology and characteristics of radioiodine uptake and correlating with anatomical imaging, biochemical data, and clinical findings, physicians can be more confident in establishing proper management for patients with DTC using radioiodine whole body scans. Research Support: N/A
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Lazaga, F., Sharma, S., Sharma, P., Williams, S. Tags: Educational Exhibits Posters Source Type: research

Crossed cerebellar diaschisis on F-18 FDG PET/CT and MRI/Functional MRI
Conclusion: CCD is likely to be permanent while a small percentage (15%) showed improvement or even complete resolution regardless of the causative insult (tumor or infarct). While MRI is the study of choice in evaluating the brain, it was not able to detect any evidence of abnormal morphology, signal or blood flow in the cerebellum of patients who have a supratentorial insult. Given the small number of cases with improvement of CCD, the clinical significance has yet to be determined. Research Support: None
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Bakdalieh, A., Osman, M., Muzaffar, R., Ghazala, H., Zhou, Y. Tags: Neurology Posters Source Type: research

18F-Choline Uptake in Acute Ischemic Stroke
Abstract: A 75-year-old man with a history of prostate cancer was referred to our department to perform 18F-choline (FCH) PET/CT. FCH PET/CT showed a markedly increased uptake in the right temporoparietal junction brain. Three weeks earlier, acute ischemic stroke was diagnosed in the right temporoparietal junction brain on diffusion-weighted sequence and thrombosis in a distal branch of the right middle cerebral artery on MR angiography. Choline precursors promote repair and growth of cell membranes in neurologic diseases, so FCH PET/CT uptake could be explained by repair processes during early outcome of acute ischemic stroke.
Source: Clinical Nuclear Medicine - January 10, 2017 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

18 F-FDG PET/CT imaging factors that predict ischaemic stroke in cancer patients
ConclusionOur findings suggest that arterial FDG uptake and hypermetabolic malignancy on PET and the VAT proportion on CT could be independent predictors of future ischaemic stroke in patients with cancer and could identify those patients who would benefit from medical treatment.
Source: European Journal of Nuclear Medicine and Molecular Imaging - October 4, 2016 Category: Nuclear Medicine Source Type: research

Brain findings on FDG PET-MRI body sequences that include the head
Conclusions FDG PET-MRI imaging is a rapidly evolving modality that is most commonly employed for cancer evaluation. The standardized base of skull to mid thigh imaging may miss many important pathologies that are discovered even with MRI body sequences. We propose that PET-MRI body sequences that include the head may show added value in the management of patients.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Franceschi, A., Matthews, R., Bangiyev, L., Relan, N., Chaudhry, A., Franceschi, D. Tags: Outcomes/Comparative Effectiveness Research & amp; Radiation Safety Source Type: research

Clinical implications for Translocator Protein (TSPO) imaging using 123ICLINDE SPECT: A feasible approach
Conclusions The preliminary results imply that [123I]CLINDE-SPECT is a feasible approach for TSPO imaging in neurological disorders associated with microglial activation and/or increased TSPO expression. The development of methods that do not need arterial blood sampling for quantification of TSPO will be important to ease implementation in a daily clinical setting. Further clinical studies are needed to determine the precise role of TSPO imaging in predicting clinical outcome and treatment response.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Thomsen, G., Jensen, P., Feng, L., Knudsen, L., Knudsen, G., Pinborg, L. Tags: Neurosciences/Neurology. Miscellaneous Source Type: research