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Specialty: Geriatrics
Drug: Aspirin
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Total 23 results found since Jan 2013.
Safety outcomes of direct oral anticoagulants in older adults with atrial fibrillation: a systematic review and meta-analysis of (subgroup analyses from) randomized controlled trials
AbstractBalancing stroke prevention and risk of bleeding in patients with atrial fibrillation (AF) is challenging. Direct oral anticoagulants (DOACs) are by now considered standard of care for treating patients with AF in international guidelines. Our objective was to assess the safety of long-term intake of DOACs in older adults with AF. We included RCTs in elderly ( ≥ 65 years) patients with AF. A systematic search in MEDLINE and EMBASE was performed on 19 April 2022. For determination of risk of bias, the RoB 2 tool was applied. We pooled outcomes using random-effects meta-analyses. The quality of evidence was as...
Source: AGE - June 1, 2023 Category: Geriatrics Source Type: research
Antiplatelets and Vascular Dementia: A Systematic Review
J Aging Res. 2022 Sep 19;2022:9780067. doi: 10.1155/2022/9780067. eCollection 2022.ABSTRACTVascular dementia (VD) is a neurocognitive disorder whose precise definition is still up for debate. VD generally refers to dementia that is primarily caused by cerebrovascular disease or impaired cerebral blood flow. It is a subset of vascular cognitive impairment, a class of diseases that relate any cerebrovascular injury as a causal or correlating factor for cognitive decline, most commonly seen in the elderly. Patients who present with both cognitive impairment and clinical or radiologic indications of cerebrovascular pathology s...
Source: Journal of Aging Research - October 17, 2022 Category: Geriatrics Authors: Peter Alexander Shakthi Visagan Sara Jawhar Amogh Kare Noor Issa Reem Issa Abbas Jawhar Sneha Thomas Vasavi Gorantla Source Type: research
The Effect of Aspirin on the Primary Prevention of Major Adverse Cardiac and Cerebrovascular Events in Chinese Older Adults: A Registration Study
ConclusionsThere were no significant benefits from using aspirin as primary prevention for MACCE in older Chinese adults.
Source: Drugs and Aging - December 6, 2021 Category: Geriatrics Source Type: research
Impact of Fall Risk and Direct Oral Anticoagulant Treatment on Quality-Adjusted Life-Years in Older Adults with Atrial Fibrillation: A Markov Decision Analysis
ConclusionsOlder adults with atrial fibrillation benefit from stroke protection of anticoagulants, especially direct oral anticoagulants, even if they are at high risk of falls. Clinicians should not consider fall risk as a deciding factor for withholding anticoagulation in this population of patients.
Source: Drugs and Aging - July 8, 2021 Category: Geriatrics Source Type: research
Association of Race and Major Adverse Cardiac Events (MACE): The Atherosclerosis Risk in Communities (ARIC) Cohort.
Conclusions: No association between race and MACE was identified after adjusting for high cholesterol, diabetes, and hypertension, suggesting that comorbidities are major determinants of MACE; medical intervention with focus on lifestyle and health management could ameliorate the development of MACE. Further studies are needed to confirm this observation.
PMID: 32280543 [PubMed]
Source: Journal of Aging Research - April 15, 2020 Category: Geriatrics Tags: J Aging Res Source Type: research
Efficacy of Aspirin in the Primary Prevention of Cardiovascular Diseases and Cancer in the Elderly: A Population-Based Cohort Study in Korea
ConclusionAspirin reduced the risks of MACCE and cancer without increasing the bleeding risk in elderly Koreans with hypertension, T2DM, or dyslipidemia. Moreover, the benefits of the long-term use of aspirin in reducing the risks of MACCE were demonstrated. However, the decision of using aspirin for primary prevention must be carefully made on an individual basis, while estimating the benefit –risk balance of aspirin.
Source: Drugs and Aging - November 21, 2019 Category: Geriatrics Source Type: research
Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-regression analysis
Conclusionswarfarin use was superior to warfarin non-use, aspirin and no antithrombotic therapy in reducing the risk of stroke/TE in older AF patients, but with a possible increase in major bleeding. NOACs were superior to warfarin for stroke/TE prevention, with reduced risk of major bleeding.
Source: Age and Ageing - September 8, 2017 Category: Geriatrics Source Type: research
Serum uric acid is associated with better executive function in men but not in women: Baseline assessment of the ELSA-Brasil study.
CONCLUSION: In a middle-aged subset population, SUA is associated with better performance on an executive function test in men, but not in women in the ELSA-Brasil cohort study.
PMID: 28300627 [PubMed - as supplied by publisher]
Source: Experimental Gerontology - March 10, 2017 Category: Geriatrics Authors: Baena CP, Suemoto CK, Barreto S, Lotufo P, Benseñor I Tags: Exp Gerontol Source Type: research
Cilostazol Fails to Best Aspirin for Post-Stroke Secondary Prevention (CME/CE)
(MedPage Today) -- Non-inferior overall but MI rates higher with PDE3 inhibitor
Source: MedPage Today Geriatrics - February 25, 2017 Category: Geriatrics Source Type: news
Using an Atrial Fibrillation Decision Support Tool for Thromboprophylaxis in Atrial Fibrillation: Effect of Sex and Age
ConclusionPhysicians should understand that female sex is a significant risk factor for AF‐related stroke and incorporate this into decision‐making about thromboprophylaxis. Treating older adults with aspirin instead of OAT exposes them to significant risk of bleeding with little to no reduction in AF‐related stroke risk.
Source: Journal of the American Geriatrics Society - May 24, 2016 Category: Geriatrics Authors: Mark H. Eckman, Gregory Y.H. Lip, Ruth E. Wise, Barbara Speer, Megan Sullivan, Nita Walker, Brett Kissela, Matthew L. Flaherty, Dawn Kleindorfer, Peter Baker, Robert Ireton, Dave Hoskins, Brett M. Harnett, Carlos Aguilar, Anthony Leonard, Lora Arduser, Dy Tags: Clinical Investigations Source Type: research
Controversies in antiplatelet therapy in the secondary prevention of stroke
Publication date: Available online 19 January 2016 Source:European Geriatric Medicine Author(s): T. Adamek Recurrence of stroke has been estimated at 3–4% yearly after TIA or stroke. There is no clear agreement in choosing antiplatelet therapy at this time. Europeans, Americans and British guidelines have been different. Aspirin is still used in secondary prevention of ischemic stroke, because of the longest experience with the best-achieved results in different studies and low price. Other used drugs are a combination of aspirin and dipyridamole, P2Y12 receptor antagonists – clopidogrel, ticlopidine, prasugrel an...
Source: European Geriatric Medicine - January 20, 2016 Category: Geriatrics Source Type: research
Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial
Conclusions: older patients with AF are at particularly high risk of stroke if given aspirin and have substantially greater relative and absolute benefits from apixaban compared with younger patients with no greater risk of haemorrhage.
Clinical Trial Registration: ClinicalTrials.gov number: NCT00496769. URL: https://clinicaltrials.gov/ct2/show/NCT00496769.
Source: Age and Ageing - January 13, 2016 Category: Geriatrics Authors: Ng, K. H., Shestakovska, O., Connolly, S. J., Eikelboom, J. W., Avezum, A., Diaz, R., Lanas, F., Yusuf, S., Hart, R. G. Tags: Research Papers Source Type: research
Comparing Cerebralcare Granule and aspirin for neurological dysfunction in acute stroke in real‐life practice
ConclusionsThis large‐scale, controlled trial indicated that CG may be a useful treatment in the management of post‐stroke patients.
Source: Psychogeriatrics - January 12, 2016 Category: Geriatrics Authors: Luqing Zhao, Lianming Liao, Fengyun Hu Tags: Original Article Source Type: research
