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Specialty: Stem Cells

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Total 184 results found since Jan 2013.

Implantation of the clinical ‐grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid‐lesioned rodent model of Huntington's disease
In this study, we investigated whethe r a clonal, conditionally immortalized neural stem cell line (CTX0E03), which has already shown safety and signals of efficacy in chronic ischemic stroke patients, could rescue deficits seen in an animal model of HD. After CTX0E03 transplantation into the quinolinic acid‐lesioned rat model of HD, behavioral changes were measured using the rotarod, stepping, and staircase tests. In vivo differentiation and neuronal connections of the transplanted CTX0E03 cells were evaluated with immunohistochemical staining and retrograde tracing with Fluoro‐Gold. We found that transplantation of C...
Source: Stem Cells - May 5, 2020 Category: Stem Cells Authors: Yongwoo Yoon, Hyun Sook Kim, Iksoo Jeon, Jeong ‐Eun Noh, Hyun Jung Park, Suji Lee, In‐Hyun Park, Lara Stevanato, Caroline Hicks, Randolph Corteling, Roger A. Barker, John D. Sinden, Jihwan Song Tags: REGENERATIVE MEDICINE Source Type: research

Long noncoding RNA mediates stroke ‐induced neurogenesis
In this study, we found that H19 was the most highly upregulated lncRNA in neural stem cells (NSCs) of the subventricular zone (SVZ) of rats subjected to focal cerebral ischemia. Deletion o f H19 suppressed cell proliferation, promoted cell death, and blocked NSC differentiation. RNA sequencing analysis revealed that genes deregulated by H19 knockdown were those that are involved in transcription, apoptosis, proliferation, cell cycle, and response to hypoxia. H19 knockdown significantl y increased the transcription of cell cycle‐related genes including p27, whereas overexpression of H19 substantially reduced expression o...
Source: Stem Cells - May 1, 2020 Category: Stem Cells Authors: Baoyan Fan, Wanlong Pan, Xinli Wang, Min Wei, Annie He, Anna Zhao, Michael Chopp, Zheng Gang Zhang, Xian Shuang Liu Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research

Long non ‐coding RNA mediates stroke‐induced neurogenesis
In this study, we found that H19 was the most highly upregulated lncRNA in neural stem ce lls (NSCs) of the subventricular zone (SVZ) of rats subjected to focal cerebral ischemia. Deletion of H19 suppressed cell proliferation, promoted cell death and blocked NSC differentiation. RNA sequencing analysis revealed that genes deregulated by H19 knockdown were those that are involved in trans cription, apoptosis, proliferation, cell cycle and response to hypoxia. H19 knockdown significantly increased the transcription of cell cycle‐related genes including p27, whereas overexpression of H19 substantially reduced expression of ...
Source: Stem Cells - April 27, 2020 Category: Stem Cells Authors: Baoyan Fan, Wanlong Pan, Xinli Wang, Min Wei, Annie He, Anna Zhao, Michael Chopp, Zheng Gang Zhang, Xian Shuang Liu Tags: Stem Cell Technology: Epigenetics, Genomics, Proteomics and Metabonomics Source Type: research

Low dose of extracellular vesicles identified that promote recovery after ischemic stroke
Mesenchymal stem cell-derived extracellular vesicles (EVs) are one of the most promising therapeutics in protective and/or regenerative therapy in animal models of stroke using a dose of 100  μg. However, wheth...
Source: Stem Cell Research and Therapy - February 19, 2020 Category: Stem Cells Authors: Laura Otero-Ortega, Fernando Laso-Garc ía, Mari Carmen Gómez-de Frutos, Luke Diekhorst, Arturo Martínez-Arroyo, Elisa Alonso-López, María Laura García-Bermejo, Macarena Rodríguez-Serrano, Mercedes Arrúe-Gonzalo, Exuperio Díez-Tejedor, Blanca Fuen Tags: Research Source Type: research

Systemic conditioned medium treatment from interleukin-1 primed mesenchymal stem cells promotes recovery after stroke
Mesenchymal stem cells (MSCs) hold great potential as a therapy for stroke and have previously been shown to promote recovery in preclinical models of cerebral ischaemia. MSCs secrete a wide range of growth fa...
Source: Stem Cell Research and Therapy - January 21, 2020 Category: Stem Cells Authors: Catriona J. Cunningham, Raymond Wong, Jack Barrington, Sabrina Tamburrano, Emmanuel Pinteaux and Stuart M. Allan Tags: Research Source Type: research

Recent Approaches for Angiogenesis in Search of Successful Tissue Engineering and Regeneration.
Abstract Angiogenesis plays a central role in human physiology from reproduction and fetal development to wound healing and tissue repair/regeneration. Clinically relevant therapies are needed for promoting angiogenesis in order to supply oxygen and nutrients after transplantation, thus relieving the symptoms of ischemia. Increase in angiogenesis can lead to restoration of damaged tissues, thereby leading the way for successful tissue regeneration. Tissue regeneration is a broad field that has shown the convergence of various interdisciplinary fields, wherein living cells in conjugation with biomaterials have been...
Source: Current Stem Cell Research and Therapy - November 3, 2019 Category: Stem Cells Authors: Reddy LVK, Murugan D, Mullick M, Begum M ET, Sen D Tags: Curr Stem Cell Res Ther Source Type: research

Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures
Publication date: Available online 31 October 2019Source: Stem Cell ReportsAuthor(s): Joseph Kelleher, Adam Dickinson, Stuart Cain, Yanhua Hu, Nicola Bates, Adam Harvey, Jianzhen Ren, Wenjun Zhang, Fiona C. Moreton, Keith W. Muir, Christopher Ward, Rhian M. Touyz, Pankaj Sharma, Qingbo Xu, Susan J. Kimber, Tao WangSummaryCADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is the most common form of genetic stroke and vascular dementia syndrome resulting from mutations in NOTCH3. To elucidate molecular mechanisms of the condition and identify drug targets, we established a pa...
Source: Stem Cell Reports - November 2, 2019 Category: Stem Cells Source Type: research

Cover Image
Cover Art: Serial FLAIR magnetic resonance images obtained at 1 month (left) and 24 months (right) of onset in an ischemic stroke patient treated with bone marrow ‐derived autologous mononuclear cells. See Vahidy et al. beginning on page1481.
Source: Stem Cells - October 29, 2019 Category: Stem Cells Tags: Cover Image Source Type: research

Intravenous Bone Marrow Mononuclear Cells for Acute Ischemic Stroke: Safety, Feasibility, and Effect Size from a Phase I Clinical Trial
Diffusion tensor tractography using serial multimodel magnetic resonance imaging contrast in a representation patient who received autologous bone marrow ‐derived mononuclear cells after acute ischemic stroke. AbstractCellular therapy is a promising investigational modality to enhance poststroke recovery. We conducted a single ‐arm, phase I clinical trial to determine the safety and feasibility of intravenous (IV) administration of autologous bone marrow mononuclear cells (MNCs) after acute ischemic stroke (AIS). Patients with moderate severity of AIS underwent bone marrow harvest followed by IV reinfusion of MNCs with...
Source: Stem Cells - September 16, 2019 Category: Stem Cells Authors: Farhaan S. Vahidy, Muhammad E. Haque, Mohammad H. Rahbar, Hongjian Zhu, Paul Rowan, Imoigele P. Aisiku, Dean A. Lee, Harinder S. Juneja, Susan Alderman, Andrew D. Barreto, Jose I. Suarez, Arvind Bambhroliya, Khader M. Hasan, Mallikarjuna Rao Tags: Translational and Clinical Research Source Type: research

Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats
Over 50% of acute stroke patients have hyperglycemia, which is associated with a poorer prognosis and outcome. Our aim was to investigate the impact of hyperglycemia on behavioral recovery and brain repair of ...
Source: Stem Cell Research and Therapy - July 17, 2019 Category: Stem Cells Authors: Mari Carmen G ómez-de Frutos, Fernando Laso-García, Luke Diekhorst, Laura Otero-Ortega, Blanca Fuentes, Jukka Jolkkonen, Olivier Detante, Anaick Moisan, Arturo Martínez-Arroyo, Exuperio Díez-Tejedor and María Gutiérrez-Fernández Tags: Research Source Type: research

Meta-Analysis of the Safety and Efficacy of Stem Cell Therapies for Ischemic Stroke in Preclinical and Clinical Studies
Stem Cells and Development,Volume 28, Issue 8, Page 497-514, April 15, 2019.
Source: Stem Cells and Development - April 9, 2019 Category: Stem Cells Authors: Qian Ouyang Feng Li Yu Xie Jianbang Han Zhongfei Zhang Zhiming Feng Dazhuang Su Xiaoxiong Zou Yingqian Cai Yuxi Zou Yanping Tang Xiaodan Jiang Source Type: research

Potential therapeutic roles of stem cells in ischemia-reperfusion injury
Publication date: Available online 16 March 2019Source: Stem Cell ResearchAuthor(s): M. Barzegar, G. Kaur, F.N.E. Gavins, Y. Wang, C. Boyer, J.S. AlexanderAbstractIschemia-reperfusion injury (I/RI), produced by an initial interruption of organ blood flow and its subsequent restoration, contributes significantly to the pathophysiologies of stroke, myocardial infarction, renal I/RI, intestinal I/RI and liver I/RI, which are major causes of disability (including transplant failure) and even mortality. While the restoration of blood flow is required to restore oxygen and nutrient requirements, reperfusion often triggers local ...
Source: Stem Cell Research - March 16, 2019 Category: Stem Cells Source Type: research