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Specialty: Stem Cells
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Total 184 results found since Jan 2013.
Concise Review: Cell Therapies for Stroke and Traumatic Brain Injury: Targeting Microglia
We present a model hypothesis of how several types of cell therapies may target microglia as one of the principal cell types contributing to the inflammatory response after brain injury and discuss how imaging of brain inflammation could potentially be applied to develop biomarkers in patients with stroke and TBI enrolled into stem cell clinical trials. Stem Cells 2016
Source: Stem Cells - February 22, 2016 Category: Stem Cells Authors: Sean I. Savitz, Charles S. Cox Tags: Regenerative Medicine Source Type: research
MiR‐126 Contributes to Human Umbilical Cord Blood Cell‐Induced Neurorestorative Effects After Stroke in Type‐2 Diabetic Mice
Abstract
Diabetes mellitus (DM) is a high risk factor for stroke and leads to more severe vascular and white‐matter injury than stroke in non‐DM. We tested the neurorestorative effects of delayed human umbilical cord blood cell (HUCBC) treatment of stroke in type‐2 diabetes (T2DM). db/db‐T2DM and db/+‐non‐DM mice were subjected to distal middle cerebral artery occlusion (dMCAo) and were treated 3 days after dMCAo with: (a) non‐DM + Phosphate buffered saline (PBS); (b) T2DM + PBS; (c) T2DM + naïve‐HUCBC; (d) T2DM + miR‐126−/−HUCBC. Functional evaluation, vascular and white‐matter cha...
Source: Stem Cells - January 13, 2016 Category: Stem Cells Authors: Jieli Chen, Ruizhuo Ning, Alex Zacharek, Chengcheng Cui, Xu Cui, Tao Yan, Poornima Venkat, Yi Zhang, Michael Chopp Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research
Cell therapies for stroke and traumatic brain injury: Targeting microglia
This article is protected by copyright. All rights reserved.
Source: Stem Cells - January 1, 2016 Category: Stem Cells Authors: Sean I. Savitz, Charles S. Cox Tags: Regenerative Medicine Source Type: research
Mesenchymal stem cells in the treatment of ischemic stroke: progress and possibilities.
Authors: Doeppner TR, Hermann DM
Abstract
Stroke is a major cause of death and long-term disability in industrialized countries, and the only causal therapy for stroke comprises recombinant tissue plasminogen activator(rt-PA)-mediated recanalization of the occluded vessel. New experimental strategies focus on neuroregenerative approaches, among which the application of mesenchymal stem cells (MSCs) has gained increasing attention. MSCs, like other stem cells, have the capacity of unlimited self-renewal giving rise to differentiated cells from various cell lineages. Bone marrow (BM)-derived MSCs are the most frequen...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research
Brain repair: cell therapy in stroke.
Authors: Kalladka D, Muir KW
Abstract
Stroke affects one in every six people worldwide, and is the leading cause of adult disability. Some spontaneous recovery is usual but of limited extent, and the mechanisms of late recovery are not completely understood. Endogenous neurogenesis in humans is thought to contribute to repair, but its extent is unknown. Exogenous cell therapy is promising as a means of augmenting brain repair, with evidence in animal stroke models of cell migration, survival, and differentiation, enhanced endogenous angiogenesis and neurogenesis, immunomodulation, and the secretion of trophic facto...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research
Autologous bone marrow cell therapy for peripheral arterial disease.
Authors: Botti C, Maione C, Coppola A, Sica V, Cobellis G
Abstract
Inadequate blood supply to tissues caused by obstruction of arterioles and/or capillaries results in ischemic injuries - these injuries can range from mild (eg, leg ischemia) to severe conditions (eg, myocardial infarction, stroke). Surgical and/or endovascular procedures provide cutting-edge treatment for patients with vascular disorders; however, a high percentage of patients are currently not treatable, owing to high operative risk or unfavorable vascular involvement. Therapeutic angiogenesis has recently emerged as a promising new therapy, promo...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research
Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy.
Authors: Patel AN, Genovese J
Abstract
In vitro, in vivo animal, and human clinical data show a broad field of application for mesenchymal stem cells (MSCs). There is overwhelming evidence of the usefulness of MSCs in regenerative medicine, tissue engineering, and immune therapy. At present, there are a significant number of clinical trials exploring the use of MSCs for the treatment of various diseases, including myocardial infarction and stroke, in which oxygen suppression causes widespread cell death, and others with clear involvement of the immune system, such as graft-versus-host disease, Crohn's disease, and ...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research
Imported Stem Cells Strike against Stroke.
Abstract
Cells with neural stem cell (NSC)-like properties can be isolated from the cortex of adult brains following injury, but their origins and function are unclear. Now in Cell Stem Cell, Faiz et al. (2015) show that subventricular-zone-derived NSCs home to injured cortical area following stroke, where they generate reactive astrocytes.
PMID: 26544109 [PubMed - in process]
Source: Cell Stem Cell - November 5, 2015 Category: Stem Cells Authors: Péron S, Berninger B Tags: Cell Stem Cell Source Type: research
Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke.
Abstract
Reactive astrocytes (RAs) have been reported to convert to multipotent neural stem cells (NSCs) capable of neurosphere (NS) formation and multilineage differentiation in vitro. Using genetic tagging, we determined that subventricular zone (SVZ) NSCs give rise to NSs derived from the stroke-injured cortex. We demonstrate that these cells can be isolated from the cortex in two different models of stroke and from different stroke-lesioned cortical regions. Interestingly, SVZ NSCs give rise to a subpopulation of RAs in the cortex that contribute to astrogliosis and scar formation. Last, we show that these S...
Source: Cell Stem Cell - October 6, 2015 Category: Stem Cells Authors: Faiz M, Sachewsky N, Gascón S, Bang KW, Morshead CM, Nagy A Tags: Cell Stem Cell Source Type: research
PDGFR‐β Plays a Key Role in the Ectopic Migration of Neuroblasts in Cerebral Stroke
Abstract
The neuroprotective agents and induction of endogenous neurogenesis remain to be the urgent issues to be established for the care of cerebral stroke. Platelet‐derived growth factor receptor beta (PDGFR‐β) is mainly expressed in neural stem/progenitor cells (NSPCs), neurons and vascular pericytes of the brain; however, the role in pathological neurogenesis remains elusive. To this end, we examined the role of PDGFR‐β in the migration and proliferation of NSPCs after stroke. A transient middle cerebral‐arterial occlusion (MCAO) was introduced into the mice with conditional Pdgfrb‐gene inactivation, inclu...
Source: Stem Cells - October 4, 2015 Category: Stem Cells Authors: Hikari Sato, Yoko Ishii, Seiji Yamamoto, Erika Azuma, Yoriko Takahashi, Takeru Hamashima, Akihiro Umezawa, Hisashi Mori, Satoshi Kuroda, Shunro Endo, Masakiyo Sasahara Tags: Tissue‐Specific Stem Cells Source Type: research
PDGFR ‐β Plays a Key Role in the Ectopic Migration of Neuroblasts in Cerebral Stroke
STEM CELLS, Page 685-698, July 2018.
Source: Stem Cells - October 4, 2015 Category: Stem Cells Authors: HikariSato
,
YokoIshii
,
SeijiYamamoto
,
ErikaAzuma
,
YorikoTakahashi
,
TakeruHamashima
,
AkihiroUmezawa
,
HisashiMori
,
SatoshiKuroda
,
ShunroEndo
,
MasakiyoSasahara Source Type: research
Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke
Conclusion:
Our study is the first to show enhanced exogenous repopulation of a neuronal phenotype after stroke using techniques aimed at GABAergic cell induction prior to delivery that resulted in accelerated and improved functional recovery.
Source: Stem Cell Research and Therapy - September 29, 2015 Category: Stem Cells Authors: Hima AbeysingheLaita BokhariAnita QuigleyMahesh ChoolaniJerry ChanGregory DustingJeremy CrookNao KobayashiCarli Roulston Source Type: research
Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation
STEM CELLS, Page 160-173, July 2018.
Source: Stem Cells - September 28, 2015 Category: Stem Cells Authors: HirokiUchida
,
TakahiroMorita
,
KuniyasuNiizuma
,
YoshihiroKushida
,
YasumasaKuroda
,
ShoheiWakao
,
HiroyukiSakata
,
YoshiyaMatsuzaka
,
HajimeMushiake
,
TeijiTominaga
,
Cesario V.Borlongan
,
MariDezawa Source Type: research
Transplantation of unique subpopulation of fibroblasts, Muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation
This article is protected by copyright. All rights reserved.
Source: Stem Cells - September 21, 2015 Category: Stem Cells Authors: Hiroki Uchida, Takahiro Morita, Kuniyasu Niizuma, Yoshihiro Kushida, Yasumasa Kuroda, Shohei Wakao, Hiroyuki Sakata, Yoshiya Matsuzaka, Hajime Mushiake, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Regenerative Medicine Source Type: research
CXCL12 Gene Therapy Ameliorates Ischemia-Induced White Matter Injury in Mouse Brain
This study has demonstrated for the first time that CXCL12 gene therapy significantly ameliorates brain ischemia-induced white matter injury and promotes oligodendrocyte progenitor cell proliferation in the subventricular zone and migration to the perifocal area in the ischemic mouse brain. Additional data showed that CXCR4 receptor plays an important role during the proliferation and migration of oligodendrocyte progenitor cells, and CXCR7 might play a role during maturation. In contrast to many experimental studies that provide treatment before ischemic insult, CXCL12 gene therapy was performed 1 week after brain ischemi...
Source: Stem Cells Translational Medicine - September 17, 2015 Category: Stem Cells Authors: Li, Y., Tang, G., Liu, Y., He, X., Huang, J., Lin, X., Zhang, Z., Yang, G.-Y., Wang, Y. Tags: Tissue-Specific Progenitor and Stem Cells, Neural/Progenitor Stem Cells Source Type: research
